| Enmein-type 6,7-seco-ent-Kauranoids from Isodon sculponeatus | |
Jiang, Hua-Yi1,2; Wang, Wei-Guang1; Zhou, Min1,2; Wu, Hai-Yan1,2; Zhan, Rui1; Li, Xiao-Nian1; Du, Xue1; Li, Yan1 ; Pu, Jian-Xin1; Sun, Han-Dong1
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| 通讯作者 | Pu,JX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; pujianxin@mail.kib.ac.cn ; hdsun@mail.kib.ac.cn |
| 2013-11-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 76期号:11页码:2113-2119 |
| 摘要 | Fourteen enmein-type 6,7-seco-ent-kaurane diterpenoids, seven new ones (sculponins M-S, 1-7) and seven known compounds (8-14), were isolated from the aerial parts of Isodon sculponeatus. Compound 1 is the first example of an ent-kauranoid, possessing a 11,12-epoxy group, and compounds 6 and 7 have a rare 3,6-epoxy group. The structures were established primarily by NMR and MS methods, and the absolute configurations of 1, 3, and 6 were determined by single-crystal X-ray diffraction. Compound 14 showed significant cytotoxic activity against five human tumor lines, with IC50 values ranging from 1.0 to 3.5 mu M, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 2.2 mu M. |
| 关键词 | Absolute Configuration Diterpenoids Terpenoids Trichocarpus Constituents |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000327677800016 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/17452 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Hua-Yi,Wang, Wei-Guang,Zhou, Min,et al. Enmein-type 6,7-seco-ent-Kauranoids from Isodon sculponeatus[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(11):2113-2119. |
| APA | Jiang, Hua-Yi.,Wang, Wei-Guang.,Zhou, Min.,Wu, Hai-Yan.,Zhan, Rui.,...&Sun, Han-Dong.(2013).Enmein-type 6,7-seco-ent-Kauranoids from Isodon sculponeatus.JOURNAL OF NATURAL PRODUCTS,76(11),2113-2119. |
| MLA | Jiang, Hua-Yi,et al."Enmein-type 6,7-seco-ent-Kauranoids from Isodon sculponeatus".JOURNAL OF NATURAL PRODUCTS 76.11(2013):2113-2119. |
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