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题名: Enmein-type 6,7-seco-ent-Kauranoids from Isodon sculponeatus
作者: Jiang, Hua-Yi1, 2; Wang, Wei-Guang1; Zhou, Min1, 2; Wu, Hai-Yan1, 2; Zhan, Rui1; Li, Xiao-Nian1; Du, Xue1; null(李艳)1; Pu, Jian-Xin1; null(孙汉董)1
刊名: JOURNAL OF NATURAL PRODUCTS
关键词: ABSOLUTE CONFIGURATION ; DITERPENOIDS ; TERPENOIDS ; TRICHOCARPUS ; CONSTITUENTS
英文摘要: Fourteen enmein-type 6,7-seco-ent-kaurane diterpenoids, seven new ones (sculponins M-S, 1-7) and seven known compounds (8-14), were isolated from the aerial parts of Isodon sculponeatus. Compound 1 is the first example of an ent-kauranoid, possessing a 11,12-epoxy group, and compounds 6 and 7 have a rare 3,6-epoxy group. The structures were established primarily by NMR and MS methods, and the absolute configurations of 1, 3, and 6 were determined by single-crystal X-ray diffraction. Compound 14 showed significant cytotoxic activity against five human tumor lines, with IC50 values ranging from 1.0 to 3.5 mu M, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 2.2 mu M.
出版日期: 2013-11-01
卷号: 76, 期号:11, 页码:2113-2119
语种: 英语
收录类别: SCI ; IC
ISSN号: 0163-3864
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17452
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Jiang,Hua-Yi;Wang,Wei-Guang;Zhou,Min;Wu,Hai-Yan;Zhan,Rui;Li,Xiao-Nian;Du,Xue;Li,Yan;Pu,Jian-Xin;Sun,Han-Dong.Enmein-type 6,7-seco-ent-Kauranoids from Isodon sculponeatus,JOURNAL OF NATURAL PRODUCTS,2013,76(11):2113-2119
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