Enmein-type 6,7-seco-ent-Kauranoids from Isodon sculponeatus
Jiang, Hua-Yi1,2; Wang, Wei-Guang1; Zhou, Min1,2; Wu, Hai-Yan1,2; Zhan, Rui1; Li, Xiao-Nian1; Du, Xue1; Li, Yan1; Pu, Jian-Xin1; Sun, Han-Dong1
2013-11-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号76期号:11页码:2113-2119
摘要Fourteen enmein-type 6,7-seco-ent-kaurane diterpenoids, seven new ones (sculponins M-S, 1-7) and seven known compounds (8-14), were isolated from the aerial parts of Isodon sculponeatus. Compound 1 is the first example of an ent-kauranoid, possessing a 11,12-epoxy group, and compounds 6 and 7 have a rare 3,6-epoxy group. The structures were established primarily by NMR and MS methods, and the absolute configurations of 1, 3, and 6 were determined by single-crystal X-ray diffraction. Compound 14 showed significant cytotoxic activity against five human tumor lines, with IC50 values ranging from 1.0 to 3.5 mu M, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 2.2 mu M.
关键词Absolute Configuration Diterpenoids Terpenoids Trichocarpus Constituents
资助信息National Natural Science Foundation of China [21322204, 81172939]; Major State Basic Research Development Program of China [2009CB522300]; reservation-talent project of Yunnan Province [2011CI043]; Science and Technology Program of Yunnan Province [2008IF010]; Major Direction Projection Foundation of CAS Intellectual Innovation Project [KSCX2-EW-J-24]; West Light Foundation of the Chinese Academy of Sciences
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000327677800016
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17452
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Jiang, Hua-Yi,Wang, Wei-Guang,Zhou, Min,et al. Enmein-type 6,7-seco-ent-Kauranoids from Isodon sculponeatus[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(11):2113-2119.
APA Jiang, Hua-Yi.,Wang, Wei-Guang.,Zhou, Min.,Wu, Hai-Yan.,Zhan, Rui.,...&Sun, Han-Dong.(2013).Enmein-type 6,7-seco-ent-Kauranoids from Isodon sculponeatus.JOURNAL OF NATURAL PRODUCTS,76(11),2113-2119.
MLA Jiang, Hua-Yi,et al."Enmein-type 6,7-seco-ent-Kauranoids from Isodon sculponeatus".JOURNAL OF NATURAL PRODUCTS 76.11(2013):2113-2119.
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