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Transcriptome analyses of Paris polyphylla var. chinensis, Ypsilandra thibetica, and Polygonatum kingianum characterize their steroidal saponin biosynthesis pathway 期刊论文
FITOTERAPIA, 2019, 卷号: 135, 页码: 52-63
Authors:  Yang, Zhenyan;  Yang, Lifang;  Liu, Changkun;  Qin, Xujie;  Liu, Haiyang;  Chen, Jiahui;  Ji, Yunheng
Favorite  |  View/Download:19/0  |  Submit date:2019/07/29
Steroidal saponins  Biosynthesis  Transcriptome  Monocotyledons  Cholesterol  Cycloartenol pathway  
Physalis peruviana-Derived 4 beta-Hydroxywithanolide E, a Novel Antagonist of Wnt Signaling, Inhibits Colorectal Cancer In Vitro and In Vivo 期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 6, 页码: 13
Authors:  Ye, Zhen-Nan;  Yuan, Feng;  Liu, Jie-Qing;  Peng, Xing-Rong;  An, Tao;  Li, Xue;  Kong, Ling-Mei;  Qiu, Ming-Hua;  Li, Yan
Favorite  |  View/Download:11/0  |  Submit date:2019/07/29
4 beta HWE  Wnt signaling pathway  beta-catenin  colorectal cancer  
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 285-294
Authors:  Chen, Duo-zhi;  Yang, Bi-juan;  He, Xiao-li;  Fan, Shi-rui;  Cai, Jie-yun;  Jing, Chen-xu;  Zhang, Heng;  Zhang, Yu;  Li, Lin;  Hao, Xiao-jiang
Favorite  |  View/Download:104/0  |  Submit date:2019/03/18
Wnt/beta-catenin signalling pathway agonist  Phenanthridine derivatives  Structural optimization  Structure-activity relationships (SARs)  
Basal PPAR alpha inhibits bile acid metabolism adaptation in chronic cholestatic model induced by alpha-naphthylisothiocyanate 期刊论文
TOXICOLOGY LETTERS, 2019, 卷号: 300, 页码: 31-39
Authors:  Hua, Huiying;  Dai, Manyun;  Luo, Yishuang;  Lin, Hante;  Xu, Gangming;  Hu, Xiaowei;  Xu, Liping;  Zhang, Haoyue;  Tang, Zhiyuan;  Chang, Liming;  Liu, Aiming;  Yang, Julin
Favorite  |  View/Download:174/0  |  Submit date:2018/12/18
PPAR alpha  FXR pathway  Alpha-naphthylisothiocyanate  Chronic cholestasis  
Cyclopeptide RA-V Inhibits Organ Enlargement and Tumorigenesis Induced by YAP Activation 期刊论文
CANCERS, 2018, 卷号: 10, 期号: 11, 页码: 18
Authors:  Ji, Xinyan;  Song, Lihua;  Sheng, Li;  Gao, Anhui;  Zhao, Yang;  Han, Shixun;  Zhang, Yuchao;  Zhu, Chu;  Zhao, Simeng;  Wang, Zhe;  Xu, Bohan;  Li, Li;  Li, Jia;  Tan, Ninghua;  Zhao, Bin
Favorite  |  View/Download:16/0  |  Submit date:2018/12/27
hippo pathway  YAP  TAZ  RA-V  cancer  organ size  protein synthesis  
Gene co-expression network analysis reveals coordinated regulation of three characteristic secondary biosynthetic pathways in tea plant (Camellia sinensis) 期刊论文
BMC Genomics, 2018, 卷号: 19, 期号: 1
Authors:  Tai,Yuling;  Liu,Chun;  Yu,Shuwei;  Yang,Hua;  Sun,Jiameng;  Guo,Chunxiao;  Huang,Bei;  Liu,Zhaoye;  Yuan,Yi;  Xia,Enhua;  Wei,Chaoling;  Wan,Xiaochun
Favorite  |  View/Download:15/0  |  Submit date:2018/09/27
Tea plant  Co-expression network analysis  Characteristic metabolites  RNA-seq  Secondary metabolic pathway  
Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola 期刊论文
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2018, 卷号: 430, 页码: 1-7
Authors:  Chen, Xinglong;  Deng, Zhentao;  Huang, Xiaoyan;  Geng, Changan;  Chen, Jijun
Favorite  |  View/Download:151/0  |  Submit date:2018/07/16
Lc-ms  Xanthine Oxidase Inhibitor  Anti-gout  Mass Fragmentation Pathway  Cistanche Deserticola  
Saponins From Paris forrestii (Takht.) H. Li Display Potent Activity Against Acute Myeloid Leukemia by Suppressing the RNF6/AKT/mTOR Signaling Pathway 期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9, 页码: 673
Authors:  Lu, Qin;  He, Yuanming;  Wang, Yuehu;  Gao, Li;  Zheng, Yunjing;  Zhang, Zubin;  Cao, Biyin;  Wang, Qi;  Mao, Xinliang;  Hu, Shaoyan
Favorite  |  View/Download:110/0  |  Submit date:2018/07/30
Tspf  Rnf6/akt/mtor Signaling Pathway  Acute Myeloid Leukemia  Herbal Medicine  Saponins  Cell Apoptosis  Rnf6  
Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 150, 页码: 189-199
Authors:  Li, Mingyue;  Yue, Grace Gar-Lee;  Song, Li-Hua;  Huang, Mao-Bo;  Lee, Julia Kin-Ming;  Tsui, Stephen Kwok-Wing;  Fung, Kwok-Pui;  Tan, Ning-Hua;  Lau, Clara Bik-San
View  |  Adobe PDF(2333Kb)  |  Favorite  |  View/Download:50/7  |  Submit date:2018/07/02
Bigelovin  Colorectal Cancer  Metastasis  Tumor Microenvironment  Ll6/stat3 Pathway  
Rubipodanones A-D, naphthohydroquinone dimers from rhizomes of &ITRubia podantha &IT 期刊论文
PHYTOCHEMISTRY, 2018, 卷号: 145, 页码: 153-160
Authors:  Wang, Zhe;  Zhao, Si-Meng;  Hu, Yan-Yun;  Feng, Li;  Zhao, Li-Mei;  Di, Ying-Tong;  Tan, Ning-Hua
View  |  Adobe PDF(1384Kb)  |  Favorite  |  View/Download:113/13  |  Submit date:2018/05/08
Rubia Podantha  Rubiaceae  Naphthohydroquinone Dimers  Rubipodanones A-d  Cytotoxicity  Nf-kappa b Signaling Pathway