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Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 285-294
Authors:  Chen, Duo-zhi;  Yang, Bi-juan;  He, Xiao-li;  Fan, Shi-rui;  Cai, Jie-yun;  Jing, Chen-xu;  Zhang, Heng;  Zhang, Yu;  Li, Lin;  Hao, Xiao-jiang
Favorite  |  View/Download:78/0  |  Submit date:2019/03/18
Wnt/beta-catenin signalling pathway agonist  Phenanthridine derivatives  Structural optimization  Structure-activity relationships (SARs)  
Basal PPAR alpha inhibits bile acid metabolism adaptation in chronic cholestatic model induced by alpha-naphthylisothiocyanate 期刊论文
TOXICOLOGY LETTERS, 2019, 卷号: 300, 页码: 31-39
Authors:  Hua, Huiying;  Dai, Manyun;  Luo, Yishuang;  Lin, Hante;  Xu, Gangming;  Hu, Xiaowei;  Xu, Liping;  Zhang, Haoyue;  Tang, Zhiyuan;  Chang, Liming;  Liu, Aiming;  Yang, Julin
Favorite  |  View/Download:168/0  |  Submit date:2018/12/18
PPAR alpha  FXR pathway  Alpha-naphthylisothiocyanate  Chronic cholestasis  
Cyclopeptide RA-V Inhibits Organ Enlargement and Tumorigenesis Induced by YAP Activation 期刊论文
CANCERS, 2018, 卷号: 10, 期号: 11, 页码: 18
Authors:  Ji, Xinyan;  Song, Lihua;  Sheng, Li;  Gao, Anhui;  Zhao, Yang;  Han, Shixun;  Zhang, Yuchao;  Zhu, Chu;  Zhao, Simeng;  Wang, Zhe;  Xu, Bohan;  Li, Li;  Li, Jia;  Tan, Ninghua;  Zhao, Bin
Favorite  |  View/Download:10/0  |  Submit date:2018/12/27
hippo pathway  YAP  TAZ  RA-V  cancer  organ size  protein synthesis  
Gene co-expression network analysis reveals coordinated regulation of three characteristic secondary biosynthetic pathways in tea plant (Camellia sinensis) 期刊论文
BMC Genomics, 2018, 卷号: 19, 期号: 1
Authors:  Tai,Yuling;  Liu,Chun;  Yu,Shuwei;  Yang,Hua;  Sun,Jiameng;  Guo,Chunxiao;  Huang,Bei;  Liu,Zhaoye;  Yuan,Yi;  Xia,Enhua;  Wei,Chaoling;  Wan,Xiaochun
Favorite  |  View/Download:3/0  |  Submit date:2018/09/27
Tea plant  Co-expression network analysis  Characteristic metabolites  RNA-seq  Secondary metabolic pathway  
Liquid chromatography-mass spectrometry combined with xanthine oxidase inhibition profiling for identifying the bioactive constituents from Cistanche deserticola 期刊论文
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2018, 卷号: 430, 页码: 1-7
Authors:  Chen, Xinglong;  Deng, Zhentao;  Huang, Xiaoyan;  Geng, Changan;  Chen, Jijun
Favorite  |  View/Download:129/0  |  Submit date:2018/07/16
Lc-ms  Xanthine Oxidase Inhibitor  Anti-gout  Mass Fragmentation Pathway  Cistanche Deserticola  
Saponins From Paris forrestii (Takht.) H. Li Display Potent Activity Against Acute Myeloid Leukemia by Suppressing the RNF6/AKT/mTOR Signaling Pathway 期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9, 页码: 673
Authors:  Lu, Qin;  He, Yuanming;  Wang, Yuehu;  Gao, Li;  Zheng, Yunjing;  Zhang, Zubin;  Cao, Biyin;  Wang, Qi;  Mao, Xinliang;  Hu, Shaoyan
Favorite  |  View/Download:96/0  |  Submit date:2018/07/30
Tspf  Rnf6/akt/mtor Signaling Pathway  Acute Myeloid Leukemia  Herbal Medicine  Saponins  Cell Apoptosis  Rnf6  
Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 150, 页码: 189-199
Authors:  Li, Mingyue;  Yue, Grace Gar-Lee;  Song, Li-Hua;  Huang, Mao-Bo;  Lee, Julia Kin-Ming;  Tsui, Stephen Kwok-Wing;  Fung, Kwok-Pui;  Tan, Ning-Hua;  Lau, Clara Bik-San
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Bigelovin  Colorectal Cancer  Metastasis  Tumor Microenvironment  Ll6/stat3 Pathway  
Rubipodanones A-D, naphthohydroquinone dimers from rhizomes of &ITRubia podantha &IT 期刊论文
PHYTOCHEMISTRY, 2018, 卷号: 145, 页码: 153-160
Authors:  Wang, Zhe;  Zhao, Si-Meng;  Hu, Yan-Yun;  Feng, Li;  Zhao, Li-Mei;  Di, Ying-Tong;  Tan, Ning-Hua
View  |  Adobe PDF(1384Kb)  |  Favorite  |  View/Download:104/12  |  Submit date:2018/05/08
Rubia Podantha  Rubiaceae  Naphthohydroquinone Dimers  Rubipodanones A-d  Cytotoxicity  Nf-kappa b Signaling Pathway  
1,4-Naphthoquinone Triggers Nematode Lethality by Inducing Oxidative Stress and Activating Insulin/IGF Signaling Pathway in Caenorhabditis elegans10.3390/molecules22050798 期刊论文
MOLECULES, 2017, 卷号: 22, 期号: 5, 页码: 798
Authors:  Wang, Jia;  Zeng, Guangzhi;  Huang, Xiaobing;  Wang, Zhe;  Tan, Ninghua
View  |  Adobe PDF(3070Kb)  |  Favorite  |  View/Download:57/3  |  Submit date:2017/07/31
Plant-parasitic Nematode  Phytochemical  Nematocidal  Oxidative Stress  1  Insulin/igf Signaling Pathway  4-naphthoquinone  Caenorhabditis Elegans  
Longikaurin A, a natural ent-kaurane, suppresses stemness in nasopharyngeal carcinoma cells 期刊论文
ONCOLOGY LETTERS, 2017, 卷号: 13, 期号: 3, 页码: 1672-1680
Authors:  Yuan,Yan;  Du,Yong;  Hu,Xiao-Ye;  Liu,Mei-Yuan;  Du,Ji-Ke;  Liu,Xue-Min;  Yu,Hong-En;  Wang,Tian-Zhu;  Pu,Jian-Xin;  Zhong,Qian;  Zou,Qing-Feng
View  |  Adobe PDF(1897Kb)  |  Favorite  |  View/Download:112/6  |  Submit date:2017/10/23
Side Population  C-myc  Cancer  Expression  Radioresistance  Identification  Subpopulation  Combination  Pathway  Domain  Longikaurin a  Nasopharyngeal Carcinoma  Cancer Stem Cells