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Artemicapillasins A-N, cytotoxic coumaric acid analogues against hepatic stellate cell LX2 from Artemisia capillaris (Yin-Chen) 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 117, 页码: 105441
作者:  Gao,Zhen;  Huang,Xiao-Yan;  Geng,Chang-An;  Li,Tian-Ze;  Chen,Ji-Jun
浏览  |  Adobe PDF(1872Kb)  |  收藏  |  浏览/下载：103/31  |  提交时间：2022/04/02
Artemisia capillaris  Coumaric acid analogues  Antihepatic fibrosis effects  HSC-LX2  Extracellular matrix  TRADITIONAL CHINESE HERB  ACTIVE CONSTITUENTS  LIVER FIBROSIS  
Synthesis and anti-fibrotic effects of santamarin derivatives as cytotoxic agents against hepatic stellate cell line LX2 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 41, 页码: 127994
作者:  Wang,Jin-Ping;  Li,Tian-Ze;  Huang,Xiao-Yan;  Geng,Chang-An;  Shen,Cheng;  Sun,Jin-Jin;  Xue,Dong;  Chen,Ji-Jun
浏览  |  Adobe PDF(567Kb)  |  收藏  |  浏览/下载：70/23  |  提交时间：2022/04/02
Santamarin derivatives  Anti-fibrotic effects  HSC-LX2  Extracellular matrix  NF-KAPPA-B  SESQUITERPENE LACTONES  LIVER FIBROSIS  STRUCTURE REQUIREMENT  BAY LEAF  ACTIVATION  
Cytotoxic sesquiterpenoids against hepatic stellate cell line LX2 from Artemisia lavandulaefolia 期刊论文
BIOORGANIC CHEMISTRY, 2020
作者:  Shen, Cheng;  Huang, Xiao-Yan;  Geng, Chang-An;  Li, Tian-Ze;  Wang, Jin-Ping;  Tang, Shuang;  Su, Li-Hua;  Gao, Zhen;  Zhang, Xue-Mei;  Chen, Ji-Jun
浏览  |  Adobe PDF(2199Kb)  |  收藏  |  浏览/下载：135/34  |  提交时间：2021/01/05
Synthesis of a Hexavalent Betulinic Acid Derivative as a Hemagglutinin-Targeted Influenza Virus Entry Inhibitor 期刊论文
MOLECULAR PHARMACEUTICS, 2020
作者:  Chen, Yingying;  Wang, Xinchen;  Zhu, Yinbiao;  Si, Longlong;  Zhang, Bo;  Zhang, Yongmin;  Zhang, Lihe;  Zhou, Demin;  Xiao, Sulong
浏览  |  Adobe PDF(542Kb)  |  收藏  |  浏览/下载：93/47  |  提交时间：2021/01/05
Synthesis and structure-activity relationship studies of water-soluble beta-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 166, 页码: 328-338
作者:  Liang, Shuobin;  Li, Man;  Yu, Xiaojuan;  Jin, Hongwei;  Zhang, Yongmin;  Zhang, Lihe;  Zhou, Demin;  Xiao, Sulong
浏览  |  Adobe PDF(1284Kb)  |  收藏  |  浏览/下载：223/27  |  提交时间：2019/04/15
Glycyrrhetinic acid  Cyclodextrin  Click reaction  Influenza virus  Inhibitors  
Synthesis of selective 11 beta-HSD1 inhibitors based on dammarane scaffold 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 135, 页码: 324-338
作者:  Shao, Li-Dong;  Bao, Ying;  Shen, Yu;  Su, Jia;  Leng, Ying;  Zhao, Qin-Shi
浏览  |  Adobe PDF(1336Kb)  |  收藏  |  浏览/下载：297/68  |  提交时间：2017/07/31
11 Beta-hsd1 Inhibitor  Hupehenols  Dammarane  Sar  
Two new sesquiterpenoids from cultures of the basidiomycete Tremella foliacea 期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2016, 卷号: 18, 期号: 1, 页码: 46-50
作者:  Ding, Jian-Hai;  Li, Zheng-Hui;  Wei, Kun;  Dong, Ze-Jun;  Ding, Zhi-Hui;  Feng, Tao;  Liu, Ji-Kai
浏览  |  Adobe PDF(172Kb)  |  收藏  |  浏览/下载：141/34  |  提交时间：2016/06/27
Cytotoxicities  Trefoliols b And c  11 Beta-hsd  Tremella Foliacea  
Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2015, 卷号: 78, 期号: 2, 页码: 330-334
作者:  Chen, Xuan-Qin;  Shao, Li-Dong;  Pal, Mahesh;  Shen, Yu;  Cheng, Xiao;  Xu, Gang;  Peng, Li-Yan;  Wang, Kou;  Pan, Zheng-Hong;  Li, Ming-Ming;  Leng, Ying;  He, Juan;  Zhao, Qin-Shi;  He,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Yunnan,Peoples R China.;  hejuan@mail.kib.ac.cn;  qinshizhao@mail.kib.ac.cn
浏览  |  Adobe PDF(811Kb)  |  收藏  |  浏览/下载：295/85  |  提交时间：2015/06/29
The re‑emergence of natural products for drug discovery in the genomics era 期刊论文
Nature Reviews Drug Discovery, 2015, 页码: nrd4510
作者:  Alan L. Harvey
Adobe PDF(540Kb)  |  收藏  |  浏览/下载：76/0  |  提交时间：2017/08/22
Design, Synthesis and Biological Evaluation of Caudatin Analogs as Potent Hepatitis B Virus Inhibitors 期刊论文
MEDICINAL CHEMISTRY, 2015, 卷号: 11, 期号: 2, 页码: 165-179
作者:  Wang, Li-Jun;  Chen, Hao;  Ma, Yun-Bao;  Huang, Xiao-Yan;  Geng, Chang-An;  Zhang, Xue-Mei;  Chen, Ji-Jun;  Chen,JJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.
浏览  |  Adobe PDF(375Kb)  |  收藏  |  浏览/下载：201/69  |  提交时间：2015/06/29
Anti-hbv Activity  Caudatin Analogs  Hepatitis b e Antigen (Hbeag)  Hepatitis b Surface Antigen (Hbsag)  Hbv Dna Replication  Structure-activity Relationships(Sars)  Synthesis