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Cheliensisin A Inhibits EGF-Induced Cell Transformation with Stabilization of p53 Protein Via a Hydrogen Peroxide/Chk1-Dependent Axis 期刊论文
CANCER PREVENTION RESEARCH, 2013, 卷号: 6, 期号: 9, 页码: 949-958
作者:  Zhang, Jingjie;  Gao, Guangxun;  Chen, Liang;  Deng, Xu;  Li, Jingxia;  Yu, Yonghui;  Zhang, Dongyun;  Li, Fei;  Zhang, Min;  Zhao, Qinshi;  Huang, Chuanshu
浏览  |  Adobe PDF(1677Kb)  |  收藏  |  浏览/下载：2639/233  |  提交时间：2013/10/16
Dna-damage  Cancer Chemoprevention  Induced Phosphorylation  Activation  Apoptosis  Expression  Induction  Hyperoxia  Therapy  Roles  
Henrvin和Z86靶向Wnt信号通路抗肿瘤活性及作用机制研究 学位论文
, 北京: 中国科学院大学, 2013
作者:  李兴尧
Adobe PDF(4500Kb)  |  收藏  |  浏览/下载：73/9  |  提交时间：2016/05/31
阿司匹林抗衰老机制 学位论文
, 北京: 中国科学院大学, 2013
作者:  万钦黎
Adobe PDF(2100Kb)  |  收藏  |  浏览/下载：246/9  |  提交时间：2016/05/31
阿司匹林  衰老  节食  秀丽隐杆线虫  
Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway 期刊论文
EXPERIMENTAL GERONTOLOGY, 2013, 卷号: 48, 期号: 5, 页码: 499-506
作者:  Wan, Qin-Li;  Zheng, Shan-Qing;  Wu, Gui-Sheng;  Luo, Huai-Rong
浏览  |  Adobe PDF(903Kb)  |  收藏  |  浏览/下载：977/296  |  提交时间：2013/06/08
Caenorhabditis Elegans  Aspirin  Lifespan  Ampk  Daf-16/foxo  Dietary Restriction  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：256/43  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Therapeutic Targeting of Autophagy in Disease:Biology and Pharmacology 期刊论文
Pharmacol Rev, 2013, 卷号: 65, 期号: 0, 页码: 1162–1197
作者:  Yan Cheng;  Xingcong Ren;  William N. Hait;  Jin-Ming Yang
Adobe PDF(1425Kb)  |  收藏  |  浏览/下载：38/1  |  提交时间：2017/07/24