Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway

	Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
	Wan, Qin-Li 1,2; Zheng, Shan-Qing 1,2; Wu, Gui-Sheng3,4 ; Luo, Huai-Rong1
通讯作者	Luo, HR (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, 134 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China. ; luohuairong@mail.kib.ac.cn
	2013-05-01
发表期刊	EXPERIMENTAL GERONTOLOGY
ISSN	0531-5565
卷号	48 期号:5 页码:499-506
摘要	Aspirin has been revealed to have many beneficial effects for health since it was discovered as a nonsteroidal anti-inflammatory drug (NSAID) to treat pain and inflammation. Here, we investigated the molecular mechanism of aspirin on the lifespan extension of Caenorhabditis elegans. Our results showed that aspirin could extend the lifespan of C. elegans, and increase its health span and stress resistance. The extension of lifespan by aspirin requires DAF-16/FOXO, AMPK, and LKB1, but not SIR-2.1. Aspirin could not extend the lifespan of the mutants of eat-2, clk-1, and isp-1. Aspirin could marginally extend the lifespan of long-live insulin-like receptor mutant daf-2(e1370) III. Taken together, aspirin might act through a dietary restriction-like mechanism, via increasing the AMP: ATP ratio and activating LKB1, subsequently activating AMPK, which stimulates DAF-16 to induce downstream effects through a DAF-16 translocation independent manner. (C) 2013 Elsevier Inc. All rights reserved.
关键词	Caenorhabditis Elegans Aspirin Lifespan Ampk Daf-16/foxo Dietary Restriction
学科领域	Geriatrics & Gerontology
收录类别	SCI
语种	英语
WOS记录号	WOS:000317182600007
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/16451
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 4.Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Wan, Qin-Li,Zheng, Shan-Qing,Wu, Gui-Sheng,et al. Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway[J]. EXPERIMENTAL GERONTOLOGY,2013,48(5):499-506.
APA	Wan, Qin-Li,Zheng, Shan-Qing,Wu, Gui-Sheng,&Luo, Huai-Rong.(2013).Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway.EXPERIMENTAL GERONTOLOGY,48(5),499-506.
MLA	Wan, Qin-Li,et al."Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway".EXPERIMENTAL GERONTOLOGY 48.5(2013):499-506.

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