Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
Wan, Qin-Li1,2; Zheng, Shan-Qing1,2; Wu, Gui-Sheng3,4; Luo, Huai-Rong1
Corresponding AuthorLuo, HR (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, 134 Lanhei Rd, Kunming 650201, Yunnan, Peoples R China. ; luohuairong@mail.kib.ac.cn
2013-05-01
Source PublicationEXPERIMENTAL GERONTOLOGY
ISSN0531-5565
Volume48Issue:5Pages:499-506
AbstractAspirin has been revealed to have many beneficial effects for health since it was discovered as a nonsteroidal anti-inflammatory drug (NSAID) to treat pain and inflammation. Here, we investigated the molecular mechanism of aspirin on the lifespan extension of Caenorhabditis elegans. Our results showed that aspirin could extend the lifespan of C. elegans, and increase its health span and stress resistance. The extension of lifespan by aspirin requires DAF-16/FOXO, AMPK, and LKB1, but not SIR-2.1. Aspirin could not extend the lifespan of the mutants of eat-2, clk-1, and isp-1. Aspirin could marginally extend the lifespan of long-live insulin-like receptor mutant daf-2(e1370) III. Taken together, aspirin might act through a dietary restriction-like mechanism, via increasing the AMP: ATP ratio and activating LKB1, subsequently activating AMPK, which stimulates DAF-16 to induce downstream effects through a DAF-16 translocation independent manner. (C) 2013 Elsevier Inc. All rights reserved.
KeywordCaenorhabditis Elegans Aspirin Lifespan Ampk Daf-16/foxo Dietary Restriction
Subject AreaGeriatrics & Gerontology
Indexed BySCI
Language英语
WOS Research AreaGeriatrics & Gerontology
WOS SubjectGeriatrics & Gerontology
WOS IDWOS:000317182600007
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/16451
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
4.Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Wan, Qin-Li,Zheng, Shan-Qing,Wu, Gui-Sheng,et al. Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway[J]. EXPERIMENTAL GERONTOLOGY,2013,48(5):499-506.
APA Wan, Qin-Li,Zheng, Shan-Qing,Wu, Gui-Sheng,&Luo, Huai-Rong.(2013).Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway.EXPERIMENTAL GERONTOLOGY,48(5),499-506.
MLA Wan, Qin-Li,et al."Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway".EXPERIMENTAL GERONTOLOGY 48.5(2013):499-506.
Files in This Item: Download All
File Name/Size DocType Version Access License
Wan-2013-Aspirin ext(903KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wan, Qin-Li]'s Articles
[Zheng, Shan-Qing]'s Articles
[Wu, Gui-Sheng]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wan, Qin-Li]'s Articles
[Zheng, Shan-Qing]'s Articles
[Wu, Gui-Sheng]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wan, Qin-Li]'s Articles
[Zheng, Shan-Qing]'s Articles
[Wu, Gui-Sheng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Wan-2013-Aspirin extends the.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.