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题名: Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
作者: Wan, Qin-Li1, 2; Zheng, Shan-Qing1, 2; Wu, Gui-Sheng3, 4; null(罗怀容)1
刊名: EXPERIMENTAL GERONTOLOGY
关键词: Caenorhabditis elegans ; Aspirin ; Lifespan ; AMPK ; DAF-16/FOXO ; Dietary restriction
英文摘要: Aspirin has been revealed to have many beneficial effects for health since it was discovered as a nonsteroidal anti-inflammatory drug (NSAID) to treat pain and inflammation. Here, we investigated the molecular mechanism of aspirin on the lifespan extension of Caenorhabditis elegans. Our results showed that aspirin could extend the lifespan of C. elegans, and increase its health span and stress resistance. The extension of lifespan by aspirin requires DAF-16/FOXO, AMPK, and LKB1, but not SIR-2.1. Aspirin could not extend the lifespan of the mutants of eat-2, clk-1, and isp-1. Aspirin could marginally extend the lifespan of long-live insulin-like receptor mutant daf-2(e1370) III. Taken together, aspirin might act through a dietary restriction-like mechanism, via increasing the AMP: ATP ratio and activating LKB1, subsequently activating AMPK, which stimulates DAF-16 to induce downstream effects through a DAF-16 translocation independent manner. (C) 2013 Elsevier Inc. All rights reserved.
出版日期: 2013-05-01
卷号: 48, 期号:5, 页码:499-506
语种: 英语
ISSN号: 0531-5565
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/16451
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
4.Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China

Recommended Citation:
Wan, Qin-Li; Zheng, Shan-Qing; Wu, Gui-Sheng; Luo, Huai-Rong.Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway,EXPERIMENTAL GERONTOLOGY,2013,48(5):499-506
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