Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
Wan, Qin-Li1,2; Zheng, Shan-Qing1,2; Wu, Gui-Sheng3,4; Luo, Huai-Rong1
2013-05-01
发表期刊EXPERIMENTAL GERONTOLOGY
ISSN0531-5565
卷号48期号:5页码:499-506
摘要Aspirin has been revealed to have many beneficial effects for health since it was discovered as a nonsteroidal anti-inflammatory drug (NSAID) to treat pain and inflammation. Here, we investigated the molecular mechanism of aspirin on the lifespan extension of Caenorhabditis elegans. Our results showed that aspirin could extend the lifespan of C. elegans, and increase its health span and stress resistance. The extension of lifespan by aspirin requires DAF-16/FOXO, AMPK, and LKB1, but not SIR-2.1. Aspirin could not extend the lifespan of the mutants of eat-2, clk-1, and isp-1. Aspirin could marginally extend the lifespan of long-live insulin-like receptor mutant daf-2(e1370) III. Taken together, aspirin might act through a dietary restriction-like mechanism, via increasing the AMP: ATP ratio and activating LKB1, subsequently activating AMPK, which stimulates DAF-16 to induce downstream effects through a DAF-16 translocation independent manner. (C) 2013 Elsevier Inc. All rights reserved.
关键词Caenorhabditis Elegans Aspirin Lifespan Ampk Daf-16/foxo Dietary Restriction
资助信息Yunnan provincial government [20080A007]; Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany [P20080-ZZ21, T20090-KF05]
学科领域Geriatrics & Gerontology
收录类别SCI
语种英语
WOS研究方向Geriatrics & Gerontology
WOS类目Geriatrics & Gerontology
WOS记录号WOS:000317182600007
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/16451
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
4.Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
推荐引用方式
GB/T 7714
Wan, Qin-Li,Zheng, Shan-Qing,Wu, Gui-Sheng,et al. Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway[J]. EXPERIMENTAL GERONTOLOGY,2013,48(5):499-506.
APA Wan, Qin-Li,Zheng, Shan-Qing,Wu, Gui-Sheng,&Luo, Huai-Rong.(2013).Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway.EXPERIMENTAL GERONTOLOGY,48(5),499-506.
MLA Wan, Qin-Li,et al."Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway".EXPERIMENTAL GERONTOLOGY 48.5(2013):499-506.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Wan-2013-Aspirin ext(903KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wan, Qin-Li]的文章
[Zheng, Shan-Qing]的文章
[Wu, Gui-Sheng]的文章
百度学术
百度学术中相似的文章
[Wan, Qin-Li]的文章
[Zheng, Shan-Qing]的文章
[Wu, Gui-Sheng]的文章
必应学术
必应学术中相似的文章
[Wan, Qin-Li]的文章
[Zheng, Shan-Qing]的文章
[Wu, Gui-Sheng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。