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Pharmacological investigation of indole alkaloids from Alstonia scholaris against chronic glomerulonephritis 期刊论文
PHYTOMEDICINE, 2023, 卷号: 118, 页码: 154958
作者:  Guo,Rui;  Shang,Jian-Hua;  Ye,Rui-Han;  Zhao,Yun-Li;  Luo,Xiao-Dong
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Alstonia scholaris  Indole alkaloids  Chronic glomerulonephritis  Network pharmacology  PI3K-AkT pathway  LEAVES  IDENTIFICATION  CONSTITUENTS  EXTRACT  MODELS  POTENT  
Hepatic Stellate Celland Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis 期刊论文
ACS NANO, 2023, 卷号: 17, 期号: 23, 页码: 23608-23625
作者:  Niu,Xia;  Meng,Yanan;  Cui,Jinjin;  Li,Rui;  Ding,Xiao;  Niu,Bingyu;  Chang,Ge;  Xu,Ning;  Li,Guiling;  Wang,Yucheng;  Wang,Lulu
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liver fibrosis  dihydrotanshinone I  hepaticstellate cells  vitamin A  cyclodextrin  liver microbiome  STRATEGY  THERAPY  TARGET  NANOPARTICLES  PATHWAY  
Guaiane-type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2023, 卷号: 41, 期号: 19, 页码: 2453-2468
作者:  Dong,Wei;  Ma,Wen-Jing;  Ma,Yun-Bao;  Li,Feng-Jiao;  Li,Tian-Ze;  Wang,Yong-Cui;  He,Xiao-Feng;  Geng,Chang-An;  Zhang,Xue-Mei;  Chen,Ji-Jun
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Artemzhongdianolides B1-B17  Artemisia zhongdianensis  Guaiane-type sesquiterpenoid dimers  Antihepatoma activity  p38MAPK pathway  Cancer  NMR spectroscopy  X-ray diffraction  ARREST  CELLS  JNK  
Characterization of two putative norlaudanosoline methyltransferases from Aristolochia debilis 期刊论文
JOURNAL OF PLANT PHYSIOLOGY, 2023, 卷号: 285, 页码: 153983
作者:  Tuo,Xiaotao;  Yu,Zhiyin;  Li,Junheng;  Qi,Yuxin;  Peng,Guoqing;  Huang,Sheng-Xiong;  Huang,Xueshuang;  Huang,Jian-Ping
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Aristolochia  Aristolochic acids  Biosynthetic pathway  Transcriptome  Methyltransferase  BENZYLISOQUINOLINE ALKALOID BIOSYNTHESIS  RATE-LIMITING STEP  NORCOCLAURINE 6-O-METHYLTRANSFERASE  PURIFICATION  
Small-Molecule Drugs in Immunotherapy 期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2023, 卷号: 23, 期号: 13, 页码: 1341-1359
作者:  Hao,Xuanrun;  Chen,Zhongliang;  Li,Haining;  Wei,Minqin;  Zuo,Zhili;  Su,Qing
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Cancer immunotherapy  inhibitors  Pd-1/Pd-L1 inhibitor  IDO inhibitor  STING agonists  ROR gamma t agonists  TGF  beta inhibitors  INDOLEAMINE 2,3-DIOXYGENASE  SIGNALING INHIBITOR  DENDRITIC CELLS  GROWTH  TUMOR  PATHWAY  PEMBROLIZUMAB  RECEPTORS  DISCOVERY  VADIMEZAN  
Multi-omics analysis reveals the evolutionary origin of diterpenoid alkaloid biosynthesis pathways in Aconitum 期刊论文
JOURNAL OF INTEGRATIVE PLANT BIOLOGY, 2023, 卷号: 65, 期号: 10, 页码: 2320-2335
作者:  Zhao,Dake;  Zhang,Ya;  Ren,Huanxing;  Shi,Yana;  Dong,Ding;  Li,Zonghang;  Cui,Guanghong;  Shen,Yong;  Mou,Zongmin;  Kennelly,Edward J.;  Huang,Luqi;  Ruan,Jue;  Chen,Suiyun;  Yu,Diqiu;  Cun,Yupeng
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Aconitum vilmorinianum  acute toxicity  biosynthetic pathway  diterpenoid alkaloid  evolutionary origin  genome assembly  PHYLOGENETIC ANALYSIS  SUPPLEMENT TREMBL  CANDIDATE GENES  R PACKAGE  TOOL  TRANSCRIPTOME  IDENTIFICATION  RANUNCULACEAE  PREDICTION  DIVERSITY  
Discovery and biological evaluation of a new type of dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase from ethnomedicinal plant Dactylicapnos scandens 期刊论文
PHYTOCHEMISTRY, 2023, 卷号: 214, 页码: 113794
作者:  Bao,Mei-Fen;  Yang,Xin-Ni;  Wu,Jing;  Liu,Jiang-Xin;  Cai,Xiang-Hai
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Dactylicapnos scandens (D. don) hutch.  Isoquinoline alkaloids  Aporphine-type alkaloids  Dactycapnine a  IDO1/TDO dual inhibitor  APORPHINE ALKALOIDS  N-OXIDE  INFLAMMATION  PATHWAY  THALIPORPHINE  COMPLEXES  CANCER  ROOTS  
Characterization and protein engineering of glycosyltransferases for the biosynthesis of diverse hepatoprotective cycloartane-type saponins in Astragalus membranaceus 期刊论文
PLANT BIOTECHNOLOGY JOURNAL, 2023
作者:  Chen,Kuan;  Zhang,Meng;  Gao,Baihan;  Hasan,Aobulikasimu;  Li,Junhao;  Bao,Yang'oujie;  Fan,Jingjing;  Yu,Rong;  Yi,Yang;  Agren,Hans;  Wang,Zilong;  Liu,Haiyang;  Ye,Min;  Qiao,Xue
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astragalosides  biosynthesis  glycosyltransferases  protein engineering  Astragalus membranaceus  FUNCTIONAL-CHARACTERIZATION  UDP-GLYCOSYLTRANSFERASES  CARBON-TETRACHLORIDE  PROTOPANAXATRIOL  PHARMACOLOGY  GENERATION  CHEMISTRY  ACCURACY  PATHWAY  
Unraveling the serial glycosylation in the biosynthesis of steroidal saponins in the medicinal plant Paris polyphylla and their antifungal action 期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 11, 页码: 4638-4654
作者:  Chen,Yuegui;  Yan,Qin;  Ji,Yunheng;  Bai,Xue;  Li,Desen;  Mu,Rongfang;  Guo,Kai;  Yang,Minjie;  Tao,Yang;  Gershenzon,Jonathan;  Liu,Yan;  Li,Shenghong
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Paris polyphylla var. yunnanensis  Steroidal saponins  Glycosyltransferases  Sugar chain elongation  Antifungal activity  CHEMICAL-CONSTITUENTS  GLYCOSYLTRANSFERASES  GLYCOSIDES  DIVERSITY  CULTIVATION  PATHWAY  FAMILY  PARTS  GENUS  STEP  
Comprehensive transcriptomic profiling reveals complex molecular mechanisms in the regulation of style-length dimorphism in Guettarda speciosa (Rubiaceae), a species with anomalous distyly 期刊论文
FRONTIERS IN PLANT SCIENCE, 2023, 卷号: 14, 页码: 1116078
作者:  Luo,Zhonglai;  Zhao,Zhongtao;  Xu,Yuanqing;  Shi,Miaomiao;  Tu,Tieyao;  Pei,Nancai;  Zhang,Dianxiang
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anomalous distyly  brassinosteroid signaling  Guettarda speciosa  heterostyly  molecular regulation  genetic convergence  PRIMULA-VULGARIS  GENE-EXPRESSION  ANNOTATION  PATHWAY  IDENTIFICATION  AUXIN  EVOLUTION  PROTEIN  GROWTH  BKI1