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Discovery of Natural Potent HMG-CoA Reductase Degraders for Lowering Cholesterol 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023
作者:  Su,Xiao-Zheng;  Zhang,Lin-Fei;  Hu,Kun;  An,Yang;  Zhang,Qiao-Peng;  Tang,Jian-Wei;  Yan,Bing-Chao;  Li,Xing-Ren;  Cai,Jie;  Li,Xiao-Nian;  Sun,Han-Dong;  Jiang,Shi-You;  Puno,Pema-Tenzin
浏览  |  Adobe PDF(7289Kb)  |  收藏  |  浏览/下载：71/12  |  提交时间：2024/07/10
Enzymes  Meroterpenoids  Natural Products  Proteomics  Semisynthesis  STATIN  FUNGUS  RISK  ACID  
Characterization of two chimeric sesterterpene synthases from a fungal symbiont isolated from a sesterterpenoid-producing Lamiaceae plant Leucosceptrum canum 期刊论文
CHINESE CHEMICAL LETTERS, 2023, 卷号: 34, 期号: 1, 页码: 107469
作者:  Li,Desen;  Yang,Minjie;  Mu,Rongfang;  Luo,Shihong;  Chen,Yuegui;  Li,Wenyuan;  Wang,An;  Guo,Kai;  Liu,Yan;  Li,Shenghong
浏览  |  Adobe PDF(1293Kb)  |  收藏  |  浏览/下载：63/15  |  提交时间：2024/07/22
Sesterterpenoids  Chimeric sesterterpene synthases  Plant symbiotic fungi  Alternaria alternata  Leucosceptrum canum  Anti-adipogenic activity  GLANDULAR TRICHOMES  ALTERNARIA-ALTERNATA  HARBOR  
Novel PORCN inhibitor WHN-88 targets Wnt/?-catenin pathway and prevents the growth of Wnt-driven cancers 期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2023, 卷号: 945, 页码: 175628
作者:  Yang,Qihong;  Qin,Tong;  An,Tao;  Wu,Hongna;  Xu,Gang;  Xiang,Jin;  Lei,Kangfan;  Zhang,Shaohua;  Xia,Jie;  Su,Guifeng;  Wang,Dan;  Xue,Minggao;  Kong,Lingmei;  Zhang,Wenxuan;  Wu,Song;  Li,Yan
浏览  |  Adobe PDF(7197Kb)  |  收藏  |  浏览/下载：37/10  |  提交时间：2024/07/30
PORCN inhibitor  WHN-88  Palmitoylation  Wnt-driven cancers  SIGNALING PATHWAY  PORCUPINE  STEM  GENE  ACYLTRANSFERASE  MUTATIONS  POLARITY  PROTEIN  RNF43  MICE  
Two new guaiane-type sesquiterpenes from Curcuma wenyujin 期刊论文
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2023
作者:  Jiang,Xian-Jun;  Li,Yan;  Li,Xiang-Mei;  Wen,Shi-Zhen;  Yang,Sai-Lei;  Wei,Guo-Zhu;  Geng,Chang-An
浏览  |  Adobe PDF(1300Kb)  |  收藏  |  浏览/下载：53/9  |  提交时间：2024/07/31
Curcuma wenyujin  guaiane-type sesquiterpenes  wenyujinolide A  wenyujinolide B  
Artematrovirenolides A-D and Artematrolides S-Z, Sesquiterpenoid Dimers with Cytotoxicity against Three Hepatoma Cell Lines from Artemisia atrovirens 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2022, 卷号: 40, 期号: 1, 页码: 104-114
作者:  Su,Li-Hua;  Li,Tian-Ze;  Ma,Yun-Bao;  Geng,Chang-An;  Huang,Xiao-Yan;  Zhang,Xin;  Gao,Zhen;  Chen,Ji-Jun
浏览  |  Adobe PDF(2103Kb)  |  收藏  |  浏览/下载：202/63  |  提交时间：2022/04/02
Artemisia atrovirens  Sesquiterpenoid dimers  Structure elucidation  X-ray diffraction  Antihepatoma activity  GUAIANOLIDE  ARGYI  
Synthesis and biological evaluation of (+)-paeoveitol derivatives as novel antidepressants 期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2022, 卷号: 31, 期号: 11, 页码: 2045-2057
作者:  Li, Tian-Ze;  Huang, Xiao-Yan;  Sun, Jin-Jin;  Geng, Chang-An;  Zhang, Xue-Mei;  Chen, Ji-Jun
浏览  |  Adobe PDF(1234Kb)  |  收藏  |  浏览/下载：73/15  |  提交时间：2024/04/30
(+)-Paeoveitol derivatives  Antidepressant  Forced swimming test  Monoamine neurotransmitter  
Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities 期刊论文
RSC MEDICINAL CHEMISTRY, 2022, 卷号: 13, 期号: 10, 页码: 1212-1224
作者:  Li, Tian-Ze;  Hu, Jing;  Sun, Jin-Jin;  Huang, Xiao-Yan;  Geng, Chang-An;  Liu, Shu-Bai;  Zhang, Xue-Mei;  Chen, Ji-Jun
浏览  |  Adobe PDF(932Kb)  |  收藏  |  浏览/下载：76/17  |  提交时间：2024/04/30
BENZOFURAN  
Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 114, 页码: 105072
作者:  Su,Li-Hua;  Ma,Yun-Bao;  Geng,Chang-An;  Li,Tian-Ze;  Huang,Xiao-Yan;  Hu,Jing;  Zhang,Xin;  Tang,Shuang;  Shen,Cheng;  Gao,Zhen;  Zhang,Xue-Mei;  Chen,Ji-Jun
浏览  |  Adobe PDF(2611Kb)  |  收藏  |  浏览/下载：200/84  |  提交时间：2022/04/02
Artemisia atrovirens  guaiane-type sesquiterpenoids  artematrovirenins A-P  HepG2 and Huh7 cell lines  antihepatic cytotoxicity  LACTONES  CONSTITUENTS  GUAIANOLIDES  
Artemicapillasins A-N, cytotoxic coumaric acid analogues against hepatic stellate cell LX2 from Artemisia capillaris (Yin-Chen) 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 117, 页码: 105441
作者:  Gao,Zhen;  Huang,Xiao-Yan;  Geng,Chang-An;  Li,Tian-Ze;  Chen,Ji-Jun
浏览  |  Adobe PDF(1872Kb)  |  收藏  |  浏览/下载：169/51  |  提交时间：2022/04/02
Artemisia capillaris  Coumaric acid analogues  Antihepatic fibrosis effects  HSC-LX2  Extracellular matrix  TRADITIONAL CHINESE HERB  ACTIVE CONSTITUENTS  LIVER FIBROSIS  
Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities 期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2021, 卷号: 8, 期号: 6, 页码: 1249-1256
作者:  Su,Li-Hua;  Li,Tian-Ze;  Geng,Chang-An;  Ma,Yun-Bao;  Huang,Xiao-Yan;  Wang,Jin-Ping;  Zhang,Xue-Mei;  Chen,Ji-Jun
浏览  |  Adobe PDF(1235Kb)  |  收藏  |  浏览/下载：147/56  |  提交时间：2022/04/02