Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities
Su,Li-Hua; Li,Tian-Ze; Geng,Chang-An; Ma,Yun-Bao; Huang,Xiao-Yan; Wang,Jin-Ping; Zhang,Xue-Mei; Chen,Ji-Jun
AbstractTwo sesquiterpenoid trimers, artematrotrimers A (1) and B (2), and two sesquiterpenoid dimers, artematrodimers A (3) and B (4), possessing unprecedented scaffolds with a methylene-bridged connection were identified from Artemisia atrovirens. Their structures and absolute stereochemistry were determined by comprehensive spectroscopic data, single-crystal X-ray diffraction analyses, and ECD calculations. Compounds 1-4 represent a new type of sesquiterpenoid oligomers featuring the connections between hetero sesquiterpenoid units via one or two C-C bonds. A possible biosynthetic pathway for 1-4 was also proposed. Compound 3 showed obvious cytotoxicity against HepG2 and Huh7 cell lines with IC50 values of 21.9 and 22.6 mu M, respectively.
WOS IDWOS:000631592900019
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Document Type期刊论文
Affiliation1.[Su, Li-Hua
2.Li, Tian-Ze
3.Geng, Chang-An
4.Ma, Yun-Bao
5.Huang, Xiao-Yan
6.Wang, Jin-Ping
7.Zhang, Xue-Mei
8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab PhytochemLstry & Plant Resources We, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Su,Li-Hua,Li,Tian-Ze,Geng,Chang-An,et al. Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities[J]. ORGANIC CHEMISTRY FRONTIERS,2021,8(6):1249-1256.
APA Su,Li-Hua.,Li,Tian-Ze.,Geng,Chang-An.,Ma,Yun-Bao.,Huang,Xiao-Yan.,...&Chen,Ji-Jun.(2021).Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities.ORGANIC CHEMISTRY FRONTIERS,8(6),1249-1256.
MLA Su,Li-Hua,et al."Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities".ORGANIC CHEMISTRY FRONTIERS 8.6(2021):1249-1256.
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