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Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities | |
Su,Li-Hua; Li,Tian-Ze; Geng,Chang-An; Ma,Yun-Bao; Huang,Xiao-Yan; Wang,Jin-Ping; Zhang,Xue-Mei; Chen,Ji-Jun![]() | |
2021 | |
Source Publication | ORGANIC CHEMISTRY FRONTIERS
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ISSN | 2052-4129 |
Volume | 8Issue:6Pages:1249-1256 |
Abstract | Two sesquiterpenoid trimers, artematrotrimers A (1) and B (2), and two sesquiterpenoid dimers, artematrodimers A (3) and B (4), possessing unprecedented scaffolds with a methylene-bridged connection were identified from Artemisia atrovirens. Their structures and absolute stereochemistry were determined by comprehensive spectroscopic data, single-crystal X-ray diffraction analyses, and ECD calculations. Compounds 1-4 represent a new type of sesquiterpenoid oligomers featuring the connections between hetero sesquiterpenoid units via one or two C-C bonds. A possible biosynthetic pathway for 1-4 was also proposed. Compound 3 showed obvious cytotoxicity against HepG2 and Huh7 cell lines with IC50 values of 21.9 and 22.6 mu M, respectively. |
DOI | 10.1039/d0qo01615b |
WOS ID | WOS:000631592900019 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.kib.ac.cn/handle/151853/73749 |
Collection | 中国科学院昆明植物研究所 |
Affiliation | 1.[Su, Li-Hua 2.Li, Tian-Ze 3.Geng, Chang-An 4.Ma, Yun-Bao 5.Huang, Xiao-Yan 6.Wang, Jin-Ping 7.Zhang, Xue-Mei 8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab PhytochemLstry & Plant Resources We, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
Recommended Citation GB/T 7714 | Su,Li-Hua,Li,Tian-Ze,Geng,Chang-An,et al. Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities[J]. ORGANIC CHEMISTRY FRONTIERS,2021,8(6):1249-1256. |
APA | Su,Li-Hua.,Li,Tian-Ze.,Geng,Chang-An.,Ma,Yun-Bao.,Huang,Xiao-Yan.,...&Chen,Ji-Jun.(2021).Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities.ORGANIC CHEMISTRY FRONTIERS,8(6),1249-1256. |
MLA | Su,Li-Hua,et al."Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities".ORGANIC CHEMISTRY FRONTIERS 8.6(2021):1249-1256. |
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004-A04-022-2021-苏丽花(1235KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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