Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities

doi:10.1039/d0qo01615b

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	Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities
	Su,Li-Hua ; Li,Tian-Ze ; Geng,Chang-An ; Ma,Yun-Bao ; Huang,Xiao-Yan ; Wang,Jin-Ping ; Zhang,Xue-Mei ; Chen,Ji-Jun
	2021
Source Publication	ORGANIC CHEMISTRY FRONTIERS
ISSN	2052-4129
Volume	8 Issue:6 Pages:1249-1256
Abstract	Two sesquiterpenoid trimers, artematrotrimers A (1) and B (2), and two sesquiterpenoid dimers, artematrodimers A (3) and B (4), possessing unprecedented scaffolds with a methylene-bridged connection were identified from Artemisia atrovirens. Their structures and absolute stereochemistry were determined by comprehensive spectroscopic data, single-crystal X-ray diffraction analyses, and ECD calculations. Compounds 1-4 represent a new type of sesquiterpenoid oligomers featuring the connections between hetero sesquiterpenoid units via one or two C-C bonds. A possible biosynthetic pathway for 1-4 was also proposed. Compound 3 showed obvious cytotoxicity against HepG2 and Huh7 cell lines with IC50 values of 21.9 and 22.6 mu M, respectively.
DOI	10.1039/d0qo01615b
WOS ID	WOS:000631592900019
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73749
Collection	中国科学院昆明植物研究所
Affiliation	1.[Su, Li-Hua 2.Li, Tian-Ze 3.Geng, Chang-An 4.Ma, Yun-Bao 5.Huang, Xiao-Yan 6.Wang, Jin-Ping 7.Zhang, Xue-Mei 8.Chinese Acad Sci, Kunming Inst Bot, State Key Lab PhytochemLstry & Plant Resources We, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation GB/T 7714	Su,Li-Hua,Li,Tian-Ze,Geng,Chang-An,et al. Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities[J]. ORGANIC CHEMISTRY FRONTIERS,2021,8(6):1249-1256.
APA	Su,Li-Hua.,Li,Tian-Ze.,Geng,Chang-An.,Ma,Yun-Bao.,Huang,Xiao-Yan.,...&Chen,Ji-Jun.(2021).Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities.ORGANIC CHEMISTRY FRONTIERS,8(6),1249-1256.
MLA	Su,Li-Hua,et al."Trimeric and dimeric sesquiterpenoids from Artemisia atrovirens and their cytotoxicities".ORGANIC CHEMISTRY FRONTIERS 8.6(2021):1249-1256.

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