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Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction 期刊论文
NATURE CHEMICAL BIOLOGY, 2023, 卷号: 19, 期号: 4, 页码: 468-+
作者:  Guo,Yingjie;  Zhang,Huan;  Yan,Chen;  Shen,Birong;  Zhang,Yue;  Guo,Xiangyang;  Sun,Sha;  Yu,Fan;  Yan,Jiayun;  Liu,Ronghe;  Zhang,Qianping;  Zhang,Di;  Liu,Haiyang;  Liu,Yang;  Zhang,Yaoyao;  Li,Wenlei;  Qin,Jiangyu;  Lv,He;  Wang,Zhaoxia;  Yuan,Yun;  Yang,Jie-Feng;  Zhong,Ya-Ting;  Gao,Song;  Zhou,Bing;  Liu,Lei;  Kong,Deling;  Hao,Xiaojiang;  Hu,Junjie;  Chen,Quan
浏览  |  Adobe PDF(25423Kb)  |  收藏  |  浏览/下载:77/25  |  提交时间:2024/07/25
ENDOPLASMIC-RETICULUM  PROVIDE INSIGHT  MITOFUSIN 2  MFN1  DYNAMICS  REQUIRES  DEFECTS  FISSION  CELLS  
Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 页码: 1
作者:  Yuan, Wen-Juan;  Ding, Xiao;  Wang, Zhe;  Yang, Bi-Juan;  Li, Xiao-Nian;  Zhang, Yu;  Chen, Duo-Zhi;  Li, Shun-Lin;  Chen, Quan;  Di, Ying-Tong;  Aisa, Haji Akber;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(3375Kb)  |  收藏  |  浏览/下载:334/66  |  提交时间:2017/12/18
Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 8, 页码: 1884-1888
作者:  Yan, Chen;  Huang, Li;  Liu, Hong-Chun;  Chen, Duo-Zhi;  Liu, Hai-Yang;  Li, Xiao-Hui;  Zhang, Yu;  Geng, Mei-Yu;  Chen, Quan;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(1562Kb)  |  收藏  |  浏览/下载:354/60  |  提交时间:2014/06/23
Spiramine Derivative  Bax(-/-)/bak(-/-) Cells  Alpha  Apoptosis  Beta-unsaturated Ketone  Cytotoxicity  
A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30 期刊论文
CELL RESEARCH, 2014, 卷号: 24, 期号: 4, 页码: 482-496
作者:  Yue, Wen;  Chen, Ziheng;  Liu, Haiyang;  Yan, Chen;  Chen, Ming;  Feng, Du;  Yan, Chaojun;  Wu, Hao;  Du, Lei;  Wang, Yueying;  Liu, Jinhua;  Huang, Xiaohu;  Xia, Laixin;  Liu, Lei;  Wang, Xiaohui;  Jin, Haijing;  Wang, Jun;  Song, Zhiyin;  Hao, Xiaojiang;  Chen, Quan
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Mitochondrial Fusion  Mitofusin1/2  Deubiquitinase Usp30  15-oxospiramilactone  
A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis 期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2013, 卷号: 63, 期号: SI, 页码: 485-494
作者:  Liu, Jinhua;  Mu, Chenglong;  Yue, Wen;  Li, Jie;  Ma, Biao;  Zhao, Lixia;  Liu, Lei;  Chen, Quan;  Yan, Chen;  Liu, Haiyang;  Hao, Xiaojiang;  Zhu, Yushan
浏览  |  Adobe PDF(2679Kb)  |  收藏  |  浏览/下载:360/67  |  提交时间:2013/10/16
Thioredoxin Reductase  Bim  Ros  Apoptosis  Cancer  
Natural Diterpenoid Compound Elevates Expression of Bim Protein, Which Interacts with Antiapoptotic Protein Bcl-2, Converting It to Proapoptotic Bax-like Molecule 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 卷号: 287, 期号: 2, 页码: 1054-1065
作者:  Zhao, Lixia;  He, Feng;  Liu, Haiyang;  Zhu, Yushan;  Tian, Weili;  Gao, Ping;  He, Hongping;  Yue, Wen;  Lei, Xiaobo;  Ni, Biyun;  Wang, Xiaohui;  Jin, Haijing;  Hao, Xiaojiang;  Lin, Jialing;  Chen, Quan
浏览  |  Adobe PDF(2908Kb)  |  收藏  |  浏览/下载:264/75  |  提交时间:2015/06/17
抗肿瘤先导化合物S-3的研究 期刊论文
中国化学会第9届天然有机化学学术会议论文集, 2012, 页码: 1
作者:  郝小江;  李林;  陈佺
浏览  |  Adobe PDF(87Kb)  |  收藏  |  浏览/下载:826/372  |  提交时间:2013/05/03
先导化合物:7492  S-3:5993  抗肿瘤:2713  构效关系研究:632  复合群:349  细胞毒活性:122  生物碱:105  肿瘤抑制率:84  衍生物:59  凋亡:57  化学成分:52  抑制活性:51  绣线菊属:37  生物活性:37  抑制肿瘤:31  动物实验:31  肿瘤细胞:15  植物地理学:14  结肠肿瘤:12  Catenin:11  
15-氧代绣线菊内酯,其药物组合物和其制备方法及其应用 专利
申请日期: 2008-03-07, 公开日期: 2008-08-13
发明人:  郝小江;  陈全;  刘海洋;  赵丽霞;  邸迎彤;  金海京;  何红平;  乐雯;  高锁;  王晓慧;  杜蕾
收藏  |  浏览/下载:119/0  |  提交时间:2018/05/10
15-氧代绣线菊内酯,其药物组合物和其制备方法及其应用 专利
申请日期: 2008-03-07, 公开日期: 2012-01-04
发明人:  郝小江;  陈全;  刘海洋;  赵丽霞;  邸迎彤;  金海京;  何红平;  乐雯;  高锁;  王晓慧;  杜蕾
收藏  |  浏览/下载:136/0  |  提交时间:2018/05/10