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Discovery and synthesis of rocaglaol derivatives inducing apoptosis in HCT116 cells via suppression of MAPK signaling pathway 期刊论文
FITOTERAPIA, 2021, 卷号: 151, 页码: 104876
作者:  Yang,Hao-Jie;  Li,Ya-Nan;  Yan,Chen;  Yang,Jue;  Zeng,Yan-Rong;  Yi,Ping;  Li,Yan-Mei;  Hao,Xiao-Jiang;  Yuan,Chun-Mao
浏览  |  Adobe PDF(2804Kb)  |  收藏  |  浏览/下载：89/25  |  提交时间：2022/04/02
Dysoxylum gotadhora  Rocaglaol derivatives  HCT116  Cytotoxic activity  MAPK pathway  FLAVAGLINES  
Natural product sciences: an integrative approach to the innovations of plant natural products 期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2020
作者:  Shen, Yuemao;  Hao, Xiaojiang
浏览  |  Adobe PDF(4992Kb)  |  收藏  |  浏览/下载：110/18  |  提交时间：2021/01/05
Synthesis of novel guttiferone E and xanthochymol derivatives with cytotoxicities by inducing cell apoptosis and arresting the cell cycle phase 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 162, 页码: 765-780
作者:  Lin, Xin;  Tian, Dongsong;  Fu, Yanhui;  Li, Yanan;  Huang, Liejun;  Gu, Wei;  Song, Jialei;  Li, Yanmei;  Ben-David, Yaacov;  Wen, Min;  Yuan, Chunmao;  Hao, Xiaojiang
Adobe PDF(2607Kb)  |  收藏  |  浏览/下载：295/50  |  提交时间：2019/03/18
Polycyclic polyprenylated acylphloroglucinol  Chemical transformation  Cytotoxicity  Cell apoptosis  Cell cycle arrest  
Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 8, 页码: 1884-1888
作者:  Yan, Chen;  Huang, Li;  Liu, Hong-Chun;  Chen, Duo-Zhi;  Liu, Hai-Yang;  Li, Xiao-Hui;  Zhang, Yu;  Geng, Mei-Yu;  Chen, Quan;  Hao, Xiao-Jiang
Adobe PDF(1562Kb)  |  收藏  |  浏览/下载：306/47  |  提交时间：2014/06/23
Spiramine Derivative  Bax(-/-)/bak(-/-) Cells  Alpha  Apoptosis  Beta-unsaturated Ketone  Cytotoxicity  
A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30 期刊论文
CELL RESEARCH, 2014, 卷号: 24, 期号: 4, 页码: 482-496
作者:  Yue, Wen;  Chen, Ziheng;  Liu, Haiyang;  Yan, Chen;  Chen, Ming;  Feng, Du;  Yan, Chaojun;  Wu, Hao;  Du, Lei;  Wang, Yueying;  Liu, Jinhua;  Huang, Xiaohu;  Xia, Laixin;  Liu, Lei;  Wang, Xiaohui;  Jin, Haijing;  Wang, Jun;  Song, Zhiyin;  Hao, Xiaojiang;  Chen, Quan
Adobe PDF(1659Kb)  |  收藏  |  浏览/下载：622/58  |  提交时间：2014/05/16
Mitochondrial Fusion  Mitofusin1/2  Deubiquitinase Usp30  15-oxospiramilactone  
A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis 期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2013, 卷号: 63, 期号: SI, 页码: 485-494
作者:  Liu, Jinhua;  Mu, Chenglong;  Yue, Wen;  Li, Jie;  Ma, Biao;  Zhao, Lixia;  Liu, Lei;  Chen, Quan;  Yan, Chen;  Liu, Haiyang;  Hao, Xiaojiang;  Zhu, Yushan
Adobe PDF(2679Kb)  |  收藏  |  浏览/下载：316/61  |  提交时间：2013/10/16
Thioredoxin Reductase  Bim  Ros  Apoptosis  Cancer  
Natural Diterpenoid Compound Elevates Expression of Bim Protein, Which Interacts with Antiapoptotic Protein Bcl-2, Converting It to Proapoptotic Bax-like Molecule 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 卷号: 287, 期号: 2, 页码: 1054-1065
作者:  Zhao, Lixia;  He, Feng;  Liu, Haiyang;  Zhu, Yushan;  Tian, Weili;  Gao, Ping;  He, Hongping;  Yue, Wen;  Lei, Xiaobo;  Ni, Biyun;  Wang, Xiaohui;  Jin, Haijing;  Hao, Xiaojiang;  Lin, Jialing;  Chen, Quan
浏览  |  Adobe PDF(2908Kb)  |  收藏  |  浏览/下载：204/46  |  提交时间：2015/06/17
抗肿瘤先导化合物S-3的研究 期刊论文
中国化学会第9届天然有机化学学术会议论文集, 2012, 页码: 1
作者:  郝小江;  李林;  陈佺
浏览  |  Adobe PDF(87Kb)  |  收藏  |  浏览/下载：688/362  |  提交时间：2013/05/03
先导化合物:7492  S-3:5993  抗肿瘤:2713  构效关系研究:632  复合群:349  细胞毒活性:122  生物碱:105  肿瘤抑制率:84  衍生物:59  凋亡:57  化学成分:52  抑制活性:51  绣线菊属:37  生物活性:37  抑制肿瘤:31  动物实验:31  肿瘤细胞:15  植物地理学:14  结肠肿瘤:12  Catenin:11  
Daphnipaxianines A-D, alkaloids from Daphniphyllum paxianum 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2007, 卷号: 70, 期号: 10, 页码: 1628-1631
作者:  Mu, Shu-Zhen;  Li, Chun-Shun;  He, Hong-Ping;  Di, Ying-Tong;  Wang, Ye;  Wang, Yue-Hu;  Zhang, Zhen;  Lue, Yang;  Zhang, Li;  Hao, Xiao-Jiang
Adobe PDF(230Kb)  |  收藏  |  浏览/下载：299/142  |  提交时间：2011/11/24
Longeracemosum  
Induction of leukemia cell apoptosis by cheliensisin A involves down-regulation of Bcl-2 expression 期刊论文
ACTA PHARMACOLOGICA SINICA, 2005, 卷号: 26, 期号: 5, 页码: 623-628
作者:  Zhong, L;  Li, CM;  Hao, XJ;  Lou, LG
Adobe PDF(6986Kb)  |  收藏  |  浏览/下载：143/28  |  提交时间：2012/07/25
Goniothalamus Cheliensis  Cheliensisin a  Apoptosis  Hl-60 Cells  Bcl-2 Genes  Cyclic Amp-dependent Protein Kinases  Caspases