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Synthesis of novel guttiferone E and xanthochymol derivatives with cytotoxicities by inducing cell apoptosis and arresting the cell cycle phase 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 162, 页码: 765-780
作者:  Lin, Xin;  Tian, Dongsong;  Fu, Yanhui;  Li, Yanan;  Huang, Liejun;  Gu, Wei;  Song, Jialei;  Li, Yanmei;  Ben-David, Yaacov;  Wen, Min;  Yuan, Chunmao;  Hao, Xiaojiang
Adobe PDF(2607Kb)  |  收藏  |  浏览/下载：293/50  |  提交时间：2019/03/18
Polycyclic polyprenylated acylphloroglucinol  Chemical transformation  Cytotoxicity  Cell apoptosis  Cell cycle arrest  
A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae 期刊论文
MOLECULES, 2017, 卷号: 22, 期号: 10, 页码: 1617
作者:  Hong, Ming;  Zhang, Yongsheng;  Li, Sha;  Tan, Hor Yue;  Wang, Ning;  Mu, Shuzhen;  Hao, Xiaojiang;  Feng, Yibin
Adobe PDF(92Kb)  |  收藏  |  浏览/下载：178/71  |  提交时间：2018/05/08
Wuweizi  Network Pharmacology  Hepatoprotective Effect  
Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 8, 页码: 1884-1888
作者:  Yan, Chen;  Huang, Li;  Liu, Hong-Chun;  Chen, Duo-Zhi;  Liu, Hai-Yang;  Li, Xiao-Hui;  Zhang, Yu;  Geng, Mei-Yu;  Chen, Quan;  Hao, Xiao-Jiang
Adobe PDF(1562Kb)  |  收藏  |  浏览/下载：304/46  |  提交时间：2014/06/23
Spiramine Derivative  Bax(-/-)/bak(-/-) Cells  Alpha  Apoptosis  Beta-unsaturated Ketone  Cytotoxicity  
Pegaharmalines A and B, two novel beta-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala 期刊论文
RSC ADVANCES, 2014, 卷号: 4, 期号: 96, 页码: 53725-53729
作者:  Wang, Kai-Bo;  Yuan, Chun-Mao;  Xue, Chun-Mei;  Li, Da-Hong;  Jing, Yong-Kui;  He, Hong-Ping;  Hao, Xiao-Jiang;  Di, Ying-Tong;  Li, Zhan-Lin;  Hua, Hui-Ming;  Hua,HM (reprint author),Shenyang Pharmaceut Univ,Key Lab Struct Based Drug Design & Discovery,Minist Educ,Shenyang 110016,Peoples R China.
Adobe PDF(585Kb)  |  收藏  |  浏览/下载：260/60  |  提交时间：2015/01/20
Liverwort Lepidolaena-clavigera  Caspase-3 Inhibitory-activity  Sp No 27  Absolute-configuration  Aspergillus-fumigatus  Tetracyclic Skeleton  Chaetomium-elatum  Phialophora  Metabolites  Acetals  
Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2013, 卷号: 76, 期号: 9, 页码: 1771-1780
作者:  Liu, Qian;  Tang, Jin-Shan;  Hu, Meng-Jie;  Liu, Jie;  Chen, Hai-Feng;  Gao, Hao;  Wang, Guang-Hui;  Li, Shun-Lin;  Hao, Xiao-Jiang;  Zhang, Xiao-Kun;  Yao, Xin-Sheng
Adobe PDF(2429Kb)  |  收藏  |  浏览/下载：216/94  |  提交时间：2015/05/13
Natural Diterpenoid Compound Elevates Expression of Bim Protein, Which Interacts with Antiapoptotic Protein Bcl-2, Converting It to Proapoptotic Bax-like Molecule 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 卷号: 287, 期号: 2, 页码: 1054-1065
作者:  Zhao, Lixia;  He, Feng;  Liu, Haiyang;  Zhu, Yushan;  Tian, Weili;  Gao, Ping;  He, Hongping;  Yue, Wen;  Lei, Xiaobo;  Ni, Biyun;  Wang, Xiaohui;  Jin, Haijing;  Hao, Xiaojiang;  Lin, Jialing;  Chen, Quan
Adobe PDF(2908Kb)  |  收藏  |  浏览/下载：204/46  |  提交时间：2015/06/17
A petrol ether extract of the roots of Onosma paniculatum induces cell death in a caspase dependent manner 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2010, 卷号: 129, 期号: 2, 页码: 182-188
作者:  Rinner, Beate;  Kretschmer, Nadine;  Knausz, Heike;  Mayer, Andrea;  Boechzelt, Herbert;  Hao, Xiao-Jiang;  Heubl, Guenther;  Efferth, Thomas;  Schaider, Helmut;  Bauer, Rudolf
Adobe PDF(1522Kb)  |  收藏  |  浏览/下载：410/177  |  提交时间：2012/03/21
Onosma Paniculatum  Zicao  Cancer  Cell Cycle  Caspase-3  
Induction of leukemia cell apoptosis by cheliensisin A involves down-regulation of Bcl-2 expression 期刊论文
ACTA PHARMACOLOGICA SINICA, 2005, 卷号: 26, 期号: 5, 页码: 623-628
作者:  Zhong, L;  Li, CM;  Hao, XJ;  Lou, LG
Adobe PDF(6986Kb)  |  收藏  |  浏览/下载：143/28  |  提交时间：2012/07/25
Goniothalamus Cheliensis  Cheliensisin a  Apoptosis  Hl-60 Cells  Bcl-2 Genes  Cyclic Amp-dependent Protein Kinases  Caspases