| A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae | |
Hong, Ming1; Zhang, Yongsheng1; Li, Sha1; Tan, Hor Yue1; Wang, Ning1; Mu, Shuzhen1; Hao, Xiaojiang1 ; Feng, Yibin1
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| 2017 | |
| 发表期刊 | MOLECULES
 |
| ISSN | 1420-3049 |
| 卷号 | 22期号:10页码:1617 |
| 摘要 | Fructus schisandrae (Wuweizi in Chinese), a common traditional Chinese herbal medicine, has been used for centuries to treat chronic liver disease. The therapeutic efficacy of Wuweizi has also been validated in clinical practice. In this study, molecular docking and network analysis were carried out to explore the hepatoprotective mechanism of Wuweizi as an effective therapeutic approach to treat liver disease. Multiple active compounds of Wuweizi were docked with 44 protein targets related with viral hepatitis, fatty liver, liver fibrosis, cirrhosis, and liver cancer. A compound-target network was constructed through network pharmacology analysis, predicting the relationships of active ingredients to the targets. Our results demonstrated that schisantherin, schisandrin B, schisandrol B, kadsurin, Wuweizisu C, Gomisin A, Gomisin G, and angeloylgomisin may target with 21 intracellular proteins associated with liver diseases, especially with fatty liver disease. The CYP2E1, PPAR alpha, and AMPK genes and their related pathway may play a pivotal role in the hepatoprotective effects of Wuweizi. The network pharmacology strategy used provides a forceful tool for searching the action mechanism of traditional herbal medicines and novel bioactive ingredients. |
| 关键词 | Wuweizi Network Pharmacology Hepatoprotective Effect |
| DOI | 10.3390/molecules22101617 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/60487 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.[Hong, Ming 2.Zhang, Yongsheng 3.Li, Sha 4.Tan, Hor Yue 5.Wang, Ning 6.Feng, Yibin] Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, 10 Sassoon Rd, Pokfulam, Hong Kong, Peoples R China 7.[Hong, Ming] Guangzhou Univ Chinese Med, Inst Clin Pharmacol, 12 Jichang Rd, Guangzhou 510405, Guangdong, Peoples R China 8.[Zhang, Yongsheng] Zhejiang Chinese Med Univ, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China 9.[Mu, Shuzhen 10.Hao, Xiaojiang] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 55500, Guizhou, Peoples R China 11.[Mu, Shuzhen 12.Hao, Xiaojiang] Chinese Acad Sci, Guiyang 55500, Guizhou, Peoples R China 13.[Hao, Xiaojiang] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650000, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hong, Ming,Zhang, Yongsheng,Li, Sha,et al. A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae[J]. MOLECULES,2017,22(10):1617. |
| APA | Hong, Ming.,Zhang, Yongsheng.,Li, Sha.,Tan, Hor Yue.,Wang, Ning.,...&Feng, Yibin.(2017).A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae.MOLECULES,22(10),1617. |
| MLA | Hong, Ming,et al."A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae".MOLECULES 22.10(2017):1617. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| molecules-22-01617-s（92KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
| molecules-22-01617.p（813KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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