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Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 285-294
作者:  Chen, Duo-zhi;  Yang, Bi-juan;  He, Xiao-li;  Fan, Shi-rui;  Cai, Jie-yun;  Jing, Chen-xu;  Zhang, Heng;  Zhang, Yu;  Li, Lin;  Hao, Xiao-jiang
浏览  |  Adobe PDF(3047Kb)  |  收藏  |  浏览/下载：324/40  |  提交时间：2019/03/18
Wnt/beta-catenin signalling pathway agonist  Phenanthridine derivatives  Structural optimization  Structure-activity relationships (SARs)  
Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis 期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 11
作者:  Liu, Tangjingjun;  Xia, Lei;  Yao, Yao;  Yan, Chen;  Fan, Yanhua;  Gajendran, Babu;  Yang, Jue;  Li, You-Jun;  Chen, Juan;  Filmus, Jorge;  Spaner, David E.;  Zacksenhaus, Eldad;  Hao, Xiaojiang;  Ben-David, Yaacov
浏览  |  Adobe PDF(2055Kb)  |  收藏  |  浏览/下载：281/39  |  提交时间：2019/04/15
Efficient synthesis of new phenanthridine Wnt/b-catenin signaling pathway agonists 期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: 157, 页码: 1491-1499
作者:  Duozhi Chen;  Heng Zhang;  Chenxu Jing;  Xiaoli He;  Bijuan Yang;  Jieyun Cai;  Yunfu Zhou;  Xiaoming Song;  Lin Li;  Xiaojiang Hao
浏览  |  Adobe PDF(1966Kb)  |  收藏  |  浏览/下载：220/85  |  提交时间：2019/03/27
Integrating transcriptome and microRNA analysis identifies genes and microRNAs for AHO-induced systemic acquired resistance in N-tabacum 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 页码: 12504
作者:  Chen, Yongdui;  Dong, Jiahong;  Bennetzen, Jeffrey L.;  Zhong, Micai;  Yang, Jun;  Zhang, Jie;  Li, Shunlin;  Hao, Xiaojiang;  Zhang, Zhongkai;  Wang, Xuewen
浏览  |  Adobe PDF(3093Kb)  |  收藏  |  浏览/下载：349/68  |  提交时间：2017/10/23
Plant Innate Immunity  Acibenzolar-s-methyl  Flue-cured Tobacco  Salicylic-acid  Small Rnas  Stress Responses  Expression  Arabidopsis  Target  Mirna  
Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/beta-catenin transcriptional activity 期刊论文
CELL DISCOVERY, 2017, 卷号: 3, 页码: 17003
作者:  He, Xiaoli;  Zhang, Wenjuan;  Yan, Chen;  Nie, Fen;  Li, Chen;  Liu, Xiaofen;  Fei, Cong;  Li, Shengdi;  Song, Xiaomin;  Jia, Yingying;  Zeng, Rong;  Wu, Dianqing;  Pan, Weijun;  Hao, Xiaojiang;  Li, Lin
浏览  |  Adobe PDF(3775Kb)  |  收藏  |  浏览/下载：154/38  |  提交时间：2017/12/18
Carf  Chemical Biology  Nc043  Small Molecule  Wnt Signaling  
A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae 期刊论文
MOLECULES, 2017, 卷号: 22, 期号: 10, 页码: 1617
作者:  Hong, Ming;  Zhang, Yongsheng;  Li, Sha;  Tan, Hor Yue;  Wang, Ning;  Mu, Shuzhen;  Hao, Xiaojiang;  Feng, Yibin
浏览  |  Adobe PDF(92Kb)  |  收藏  |  浏览/下载：179/72  |  提交时间：2018/05/08
Wuweizi  Network Pharmacology  Hepatoprotective Effect  
Protein kinase C controls lysosome biogenesis independently of mTORC1 期刊论文
NATURE CELL BIOLOGY, 2016, 卷号: 18, 期号: 10, 页码: 1065-1077
作者:  Li, Yang;  Xu, Meng;  Ding, Xiao;  Yan, Chen;  Song, Zhiqin;  Chen, Lianwan;  Huang, Xiahe;  Wang, Xin;  Jian, Youli;  Tang, Guihua;  Tang, Changyong;  Di, Yingtong;  Mu, Shuzhen;  Liu, Xuezhao;  Liu, Kai;  Li, Ting;  Wang, Yingchun;  Miao, Long;  Guo, Weixiang;  Hao, Xiaojiang;  Yang, Chonglin
浏览  |  Adobe PDF(4637Kb)  |  收藏  |  浏览/下载：570/152  |  提交时间：2016/12/21
Design, Synthesis, and Structural Optimization of Lycorine-Derived Phenanthridine Derivatives as Wnt/beta-Catenin Signaling Pathway Agonists 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2016, 卷号: 79, 期号: 1, 页码: 180-188
作者:  Chen, Duo-Zhi;  Jing, Chen-Xu;  Cai, Jie-Yun;  Wu, Ji-Bo;  Wang, Sheng;  Yin, Jun -Lin;  Li, Xiao-Nian;  Li, Lin;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(3043Kb)  |  收藏  |  浏览/下载：321/76  |  提交时间：2016/06/27
A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30 期刊论文
CELL RESEARCH, 2014, 卷号: 24, 期号: 4, 页码: 482-496
作者:  Yue, Wen;  Chen, Ziheng;  Liu, Haiyang;  Yan, Chen;  Chen, Ming;  Feng, Du;  Yan, Chaojun;  Wu, Hao;  Du, Lei;  Wang, Yueying;  Liu, Jinhua;  Huang, Xiaohu;  Xia, Laixin;  Liu, Lei;  Wang, Xiaohui;  Jin, Haijing;  Wang, Jun;  Song, Zhiyin;  Hao, Xiaojiang;  Chen, Quan
浏览  |  Adobe PDF(1659Kb)  |  收藏  |  浏览/下载：621/58  |  提交时间：2014/05/16
Mitochondrial Fusion  Mitofusin1/2  Deubiquitinase Usp30  15-oxospiramilactone  
A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis 期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2013, 卷号: 63, 期号: SI, 页码: 485-494
作者:  Liu, Jinhua;  Mu, Chenglong;  Yue, Wen;  Li, Jie;  Ma, Biao;  Zhao, Lixia;  Liu, Lei;  Chen, Quan;  Yan, Chen;  Liu, Haiyang;  Hao, Xiaojiang;  Zhu, Yushan
浏览  |  Adobe PDF(2679Kb)  |  收藏  |  浏览/下载：316/61  |  提交时间：2013/10/16
Thioredoxin Reductase  Bim  Ros  Apoptosis  Cancer