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多花蒿烯内酯H等三种萜类化合物 衍生物合成与抗肝癌和降血糖活性 学位论文
, 2021
作者:  杨晓烔
Adobe PDF(13814Kb)  |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/20
New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity 期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 6, 页码: 1648-1666
作者:  Su,Lihua;  Zhang,Xintian;  Ma,Yunbao;  Geng,Changan;  Huang,Xiaoyan;  Hu,Jing;  Li,Tianze;  Tang,Shuang;  Shen,Cheng;  Gao,Zhen;  Zhang,Xuemei;  Chen,Ji-Jun
浏览  |  Adobe PDF(4074Kb)  |  收藏  |  浏览/下载：92/33  |  提交时间：2022/04/02
Guaianolide dimers  Artematrolides AeR  Artemisia atrovirens  Cytotoxicity  Cell cycle  Apoptosis  FARNESYL-PROTEIN TRANSFERASE  CELL-CYCLE ARREST  HEPATOCELLULAR-CARCINOMA  GUAIANOLIDES  LACTONES  INHIBITORS  ARTEMINOLIDE  APOPTOSIS  ARGYI  HELA  
Artematrovirenins A-P, guaiane-type sesquiterpenoids with cytotoxicities against two hepatoma cell lines from Artemisia atrovirens 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 114, 页码: 105072
作者:  Su,Li-Hua;  Ma,Yun-Bao;  Geng,Chang-An;  Li,Tian-Ze;  Huang,Xiao-Yan;  Hu,Jing;  Zhang,Xin;  Tang,Shuang;  Shen,Cheng;  Gao,Zhen;  Zhang,Xue-Mei;  Chen,Ji-Jun
浏览  |  Adobe PDF(2611Kb)  |  收藏  |  浏览/下载：139/72  |  提交时间：2022/04/02
Artemisia atrovirens  guaiane-type sesquiterpenoids  artematrovirenins A-P  HepG2 and Huh7 cell lines  antihepatic cytotoxicity  LACTONES  CONSTITUENTS  GUAIANOLIDES  
Artematrolide A inhibited cervical cancer cell proliferation via ROS/ERK/mTOR pathway and metabolic shift 期刊论文
PHYTOMEDICINE, 2021, 卷号: 91, 页码: 153707
作者:  Zhang,Xin-Tian;  Hu,Jing;  Su,Li-Hua;  Geng,Chang-An;  Chen,Ji-Jun
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Artemisia atrovirens  Cervical cancer  ERK pathway  Cell metabolism  ALKALINE-PHOSPHATASE  SIGNALING PATHWAY  DIFFERENTIATION  APOPTOSIS  ERK  MECHANISMS  
A natural acylphloroglucinol triggered antiproliferative possessions in HEL cells by impeding STAT3 signaling and attenuating angiogenesis in transgenic zebrafish model 期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2021, 卷号: 141, 页码: 111877
作者:  Hu,Mi;  Varier,Krishnapriya M.;  Li,Zhicao;  Qin,Xujie;  Rao,Qing;  Song,Jingrui;  Hu,Anling;  Hang,Yubing;  Yuan,Chunmao;  Gajendran,Babu;  Shu,Liping;  Wen,Min;  Li,Yanmei;  Liu,Haiyang
浏览  |  Adobe PDF(8744Kb)  |  收藏  |  浏览/下载：104/40  |  提交时间：2022/04/02
Acylphloroglucinol  HEL cells  Intrinsic apoptotic pathway  Anti-angiogenesis  STAT3  Flk-1  CALLISTEMON-CITRINUS  TUMOR ANGIOGENESIS  DNA  DERIVATIVES  ANTICANCER  APOPTOSIS  ACTIVATION  INHIBITORS  TARGETS  LEAVES  
Synthesis and anti-fibrotic effects of santamarin derivatives as cytotoxic agents against hepatic stellate cell line LX2 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 41, 页码: 127994
作者:  Wang,Jin-Ping;  Li,Tian-Ze;  Huang,Xiao-Yan;  Geng,Chang-An;  Shen,Cheng;  Sun,Jin-Jin;  Xue,Dong;  Chen,Ji-Jun
浏览  |  Adobe PDF(567Kb)  |  收藏  |  浏览/下载：81/26  |  提交时间：2022/04/02
Santamarin derivatives  Anti-fibrotic effects  HSC-LX2  Extracellular matrix  NF-KAPPA-B  SESQUITERPENE LACTONES  LIVER FIBROSIS  STRUCTURE REQUIREMENT  BAY LEAF  ACTIVATION  
Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 104963
作者:  Liu,Jiangxin;  Wu,Xing-De;  Li,Wenyan;  Yuan,Zaifeng;  Yang,Kun;  Zhao,Qin-Shi
浏览  |  Adobe PDF(3665Kb)  |  收藏  |  浏览/下载：68/9  |  提交时间：2022/04/02
Pseudolaric acid A  Hsp90 inhibitor  Apoptosis  NMR  Structure-activity relationship  Photoaffinity-based probe  Protein-ligand interaction  MOLECULAR CHAPERONE  PROTEIN  TARGET  CANCER  KINASE  NMR  IDENTIFICATION  SELECTIVITY  BINDING  DESIGN