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Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (-)-Magellanine, (+)-Magellaninone and Analogues Thereof 期刊论文
ORGANIC LETTERS, 2014, 卷号: 16, 期号: 21, 页码: 5612-5615
作者:  Jiang, Shi-Zhi;  Lei, Ting;  Wei, Kun;  Yang, Yu-Rong;  Yang,YR (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.;  yangyurong@mail.kib.ac.cn
浏览  |  Adobe PDF(356Kb)  |  收藏  |  浏览/下载：247/68  |  提交时间：2015/01/20
Alstonia-scholaris  Neurogenesis  Proliferation  
Synthesis and cytotoxic activity of novel 1-((indol-3-yl)methyl)-1H-imidazolium salts 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 21, 页码: 4926-4930
作者:  Xu, Xiao-Liang;  Wang, Jia;  Yu, Chun-Lei;  Chen, Wen;  Li, Ying-Chao;  Li, Yan;  Zhang, Hong-Bin;  Yang, Xiao-Dong;  Li,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Peoples R China.;  liyanb@mail.kib.ac.cn;  zhanghbyd@gmail.com;  xdyang@ynu.edu.cn
Adobe PDF(670Kb)  |  收藏  |  浏览/下载：382/90  |  提交时间：2014/11/25
Indole  Imidazolium Salts  Structure-activity Relationships  Cell Apoptosis  
Synthesis and evaluation of immunostimulant plasmalogen lysophosphatidylethanolamine and analogues for natural killer T cells 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 11, 页码: 2966-2973
作者:  Ni, Guanghui;  Li, Zhiyuan;  Liang, Kangjiang;  Wu, Ting;  De Libero, Gennaro;  Xia, Chengfeng
Adobe PDF(861Kb)  |  收藏  |  浏览/下载：241/67  |  提交时间：2014/06/23
Nkt Cells  Antigen  Lysophospholipids  Sar  
Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 8, 页码: 1884-1888
作者:  Yan, Chen;  Huang, Li;  Liu, Hong-Chun;  Chen, Duo-Zhi;  Liu, Hai-Yang;  Li, Xiao-Hui;  Zhang, Yu;  Geng, Mei-Yu;  Chen, Quan;  Hao, Xiao-Jiang
Adobe PDF(1562Kb)  |  收藏  |  浏览/下载：298/45  |  提交时间：2014/06/23
Spiramine Derivative  Bax(-/-)/bak(-/-) Cells  Alpha  Apoptosis  Beta-unsaturated Ketone  Cytotoxicity  
Synthesis and antitumor activities of novel dibenzo[b,d]furan-imidazole hybrid compounds 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 66, 页码: 423-437
作者:  Liu, Lan-Xiang;  Wang, Xue-Quan;  Yan, Ju-Ming;  Li, Yan;  Sun, Cheng-Jun;  Chen, Wen;  Zhou, Bei;  Zhang, Hong-Bin;  Yang, Xiao-Dong
Adobe PDF(3339Kb)  |  收藏  |  浏览/下载：343/144  |  提交时间：2013/10/16
Hybrid Compound  Imidazole  Dibenzo[b  Antitumor Activities  d]Furan  Structure-activity Relationships  
Synthesis and cytotoxic activities of novel hybrid 2-phenyl-3-alkylbenzofuran and imidazole/triazole compounds 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 15, 页码: 4297-4302
作者:  Chen, Wen;  Deng, Xiao-Yan;  Li, Yan;  Yang, Li-Juan;  Wan, Wei-Chao;  Wang, Xue-Quan;  Zhang, Hong-Bin;  Yang, Xiao-Dong
Adobe PDF(820Kb)  |  收藏  |  浏览/下载：247/46  |  提交时间：2013/10/16
Hybrid Compound  Benzofuran  Imidazole  Triazole  Structure-activity Relationships  
Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 14, 页码: 4218-4224
作者:  Zhu, Jinmei;  Wu, Chun-Feng;  Li, Xiaobing;  Wu, Gui-Sheng;  Xie, Shan;  Hu, Qian-Nan;  Deng, Zixin;  Zhu, Michael X.;  Luo, Huai-Rong;  Hong, Xuechuan
浏览  |  Adobe PDF(1174Kb)  |  收藏  |  浏览/下载：534/90  |  提交时间：2013/10/16
Alzheimer's Disease  Acetylcholinesterase  Butyrylcholinesterase  Molecular Modeling  2-aminobenzimidazole  
Dual-Functional abeo-Taxane Derivatives Destabilizing Microtubule Equilibrium and Inhibiting NF-kappa B Activation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 56, 期号: 11, 页码: 4749-4757
作者:  Zhao, Yu;  Su, Jia;  Goto, Masuo;  Morris-Natschke, Susan L.;  Li, Yan;  Zhao, Qin-Shi;  Yao, Zhu-Jun;  Lee, Kuo-Hsiung
浏览  |  Adobe PDF(531Kb)  |  收藏  |  浏览/下载：311/65  |  提交时间：2013/10/16
Natural-products  Biological-activity  Cancer-therapy  Paclitaxel  Taxol  Resistance  Drugs  Chemotherapy  Parthenolide  Brevifoliol  
Asymmetric total synthesis of Lycopodium alkaloid (+)-lycopladine A 期刊论文
TETRAHEDRON LETTERS, 2013, 卷号: 54, 期号: 22, 页码: 2858-2860
作者:  Xu, Tao;  Luo, Xiu-Li;  Yang, Yu-Rong
浏览  |  Adobe PDF(399Kb)  |  收藏  |  浏览/下载：334/93  |  提交时间：2013/07/24
Total Synthesis  Lycopladine a  Lycopodium Alkaloids  
Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 62, 页码: 111-121
作者:  Wang, Xue-Quan;  Liu, Lan-Xiang;  Li, Yan;  Sun, Cheng-Jun;  Chen, Wen;  Li, Liang;  Zhang, Hong-Bin;  Yang, Xiao-Dong
浏览  |  Adobe PDF(4369Kb)  |  收藏  |  浏览/下载：296/98  |  提交时间：2013/07/24
Hybrid Compound  2-benzylbenzofuran  Imidazole  Cytotoxic Activities  Structure-activity Relationships