Elaborating the Role of Natural Products on the Regulation of Autophagy and their Potentials in Breast Cancer Therapy
Zhou, Xunian1,2; Yue, Grace Gar-Lee2,3; Tsui, Stephen Kwok-Wing1; Pu, Jianxin4; Fung, Kwok-Pui1,2,3; Lau, Clara Bik-San2,3
2018
发表期刊CURRENT CANCER DRUG TARGETS
ISSN1568-0096
卷号18期号:3页码:239-255
摘要Autophagy is an intracellular lysosomal/vacuolar degradation system, in which the inner cytoplasmic cell membrane is degraded by the lysosomal hydrolases, followed by the resulting products released back into the cytosol. It is involved in many physiological processes which are crucial for cell growth and survival. However, disturbance in the autophagic process is often associated with a variety of human diseases, such as cancer. Breast cancer is one of the most malignant tumors characterized by the imbalanced cell proliferation, apoptosis as well as disordered autophagy regulation. The alterations of autophagy related genes or protein levels in breast cancer cells also suggested a potential implication of autophagy in breast cancer development and progression. Many natural products had been reported as potential anti-cancer agents or being considered as direct or indirect sources of new chemotherapy adjuvants to enhance the efficacy or to ameliorate the side effects through the modulation of autophagy. Investigation of the underlying mechanism of these compounds could be crucial for the development of new therapeutic or chemopreventive options for breast cancer treatment. In this review, a summary of those natural products that can regulate autophagy in breast cancer is presented and the potential value of such autophagy modulators on the development of anti-cancer drugs is also discussed.
关键词Autophagy Natural Products Breast Cancer Cancer Therapy Mtor Signaling Apoptosis
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60545
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Inst Chinese Med, Sci Ctr East Block, Shatin, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
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Zhou, Xunian,Yue, Grace Gar-Lee,Tsui, Stephen Kwok-Wing,et al. Elaborating the Role of Natural Products on the Regulation of Autophagy and their Potentials in Breast Cancer Therapy[J]. CURRENT CANCER DRUG TARGETS,2018,18(3):239-255.
APA Zhou, Xunian,Yue, Grace Gar-Lee,Tsui, Stephen Kwok-Wing,Pu, Jianxin,Fung, Kwok-Pui,&Lau, Clara Bik-San.(2018).Elaborating the Role of Natural Products on the Regulation of Autophagy and their Potentials in Breast Cancer Therapy.CURRENT CANCER DRUG TARGETS,18(3),239-255.
MLA Zhou, Xunian,et al."Elaborating the Role of Natural Products on the Regulation of Autophagy and their Potentials in Breast Cancer Therapy".CURRENT CANCER DRUG TARGETS 18.3(2018):239-255.
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