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Pharmacological investigation of indole alkaloids from Alstonia scholaris against chronic glomerulonephritis 期刊论文
PHYTOMEDICINE, 2023, 卷号: 118, 页码: 154958
作者:  Guo,Rui;  Shang,Jian-Hua;  Ye,Rui-Han;  Zhao,Yun-Li;  Luo,Xiao-Dong
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Alstonia scholaris  Indole alkaloids  Chronic glomerulonephritis  Network pharmacology  PI3K-AkT pathway  LEAVES  IDENTIFICATION  CONSTITUENTS  EXTRACT  MODELS  POTENT  
Discovery of 2-(Methylcarbonylamino) thiazole as PDE4 inhibitors via virtual screening and biological evaluation 期刊论文
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 124, 页码: 108567
作者:  Ma,Rui;  Song,Na;  Wang,Lveli;  Gu,Xi;  Xiong,Feng;  Zhang,Shuqun;  Zhang,Jie;  Yang,Weimin;  Zuo,Zhili
浏览  |  Adobe PDF(5778Kb)  |  收藏  |  浏览/下载：140/38  |  提交时间：2024/07/22
PHOSPHODIESTERASE-4 INHIBITOR  ACCURATE DOCKING  APREMILAST  EFFICACY  INSIGHTS  DISEASE  ASTHMA  POTENT  GLIDE  
Bioassay-guided isolation of α-Glucosidase inhibitory constituents from Hypericum sampsonii 期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2023, 卷号: 21, 期号: 6, 页码: 443-453
作者:  Tao,Linlan;  Xu,Shuangyu;  Zhang,Zizhen;  Li,Yanan;  Yang,Jue;  Gu,Wei;  Yi,Ping;  Hao,Xiaojiang;  Yuan,Chunmao
浏览  |  Adobe PDF(1033Kb)  |  收藏  |  浏览/下载：199/64  |  提交时间：2024/07/22
Hypericum sampsonii  Chemical constituents  Structure elucidation  alpha-Glucosidase  Molecular docking  POLYCYCLIC POLYPRENYLATED ACYLPHLOROGLUCINOLS  POTENT INHIBITORS  SPECTROSCOPY  DERIVATIVES  CHEMISTRY  AMYLASE  ROOTS  
Design, Synthesis, and Evaluation of the COX-2 Inhibitory Activities of New 1,3-Dihydro-2H-indolin-2-one Derivatives 期刊论文
MOLECULES, 2023, 卷号: 28, 期号: 12, 页码: 4668
作者:  Pan,Taohua;  He,Maofei;  Deng,Lulu;  Li,Jiang;  Fan,Yanhua;  Hao,Xiaojiang;  Mu,Shuzhen
浏览  |  Adobe PDF(3057Kb)  |  收藏  |  浏览/下载：173/37  |  提交时间：2024/05/09
oxindoles  alpha,beta-unsaturated ketone  anti-inflammatory  COX-2 inhibitory activity  ANTIINFLAMMATORY ACTIVITY  NATURAL-PRODUCTS  OXINDOLE-DERIVATIVES  NITRIC-OXIDE  POTENT  CYCLOOXYGENASE-2  DISCOVERY  PAIN  LIABILITY  
Meroterpenoids and alkaloids from Ganoderma australe 期刊论文
NATURAL PRODUCT RESEARCH, 2021, 卷号: 35, 期号: 19, 页码: 3226-3232
作者:  Zhang,Jiao-Jiao;  Dong,Yun;  Qin,Fu-Ying;  Yan,Yong-Ming;  Cheng,Yong-Xian
收藏  |  浏览/下载：172/0  |  提交时间：2022/04/02
Ganoderma australe  meroterpenoids  alkaloids  neuroprotection  LUCIDUM  INHIBITORS  EXTRACT  POTENT  
An Approach for the Synthesis of Pyrazolo[1,5-a]pyrimidines via Cu(II)-Catalyzed [3+3] Annulation of Saturated Ketones with Aminopyrazoles 期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 86, 期号: 18, 页码: 12762-12771
作者:  Ren,Jian;  Ding,Shihua;  Li,Xiaonian;  Bi,Ran;  Zhao,Qinshi
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BIOLOGICAL EVALUATION  REGIOSELECTIVE SYNTHESIS  CASCADE REACTIONS  FUNCTIONALIZATION  DEHYDROGENATION  DISCOVERY  POTENT  BOND  SAR  
Discovery of novel modulators targeting human TRPC5: Docking-based virtual screening, molecular dynamics simulation and binding af fi nity predication 期刊论文
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2021, 卷号: 102, 页码: 107795
作者:  Liu,Bin;  Zhang,Wei;  Guo,Sheng;  Zuo,Zhili
浏览  |  Adobe PDF(4277Kb)  |  收藏  |  浏览/下载：214/26  |  提交时间：2022/04/02
hTRPC5  Homology modeling  Molecular docking  Molecular dynamics simulation  Virtual screening  INHIBITOR  CHANNELS  GROMACS  POTENT  AMBER  IDENTIFICATION  CONSTRAINTS  INTEGRATION  AMYGDALA  
(+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3 期刊论文
RSC ADVANCES, 2017, 卷号: 7, 期号: 60, 页码: 38037-38043
作者:  Luo, Qi;  Wang, Zhen;  Luo, Jin-Feng;  Tu, Zheng-Chao;  Cheng, Yong-Xian
浏览  |  Adobe PDF(795Kb)  |  收藏  |  浏览/下载：234/58  |  提交时间：2017/10/23
(+/-)-lingzhiol  Biosynthesis  Lucidum  Potent  Ddr1  
Peganumine A, a beta-Carboline Dimer with a New Octacyclic Scaffold from Peganum harmala 期刊论文
ORGANIC LETTERS, 2014, 卷号: 16, 期号: 15, 页码: 4028-4031
作者:  Wang, Kai-Bo;  Di, Ying-Tong;  Bao, Yu;  Yuan, Chun-Mao;  Chen, Gang;  Li, Da-Hong;  Bai, Jiao;  He, Hong-Ping;  Hao, Xiao-Jiang;  Pei, Yue-Hu;  Jing, Yong-Kui;  Li, Zhan-Lin;  Hua, Hui-Ming;  Li, ZL (reprint author), Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China.;  lzl1030@hotmail.com;  huimhua@163.com
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Light-emitting-diodes  Alkaloid Extract  Potent  L.  Derivatives  Efficiency  Toxicity  Harmine  Cascade  Growth  
Two New Highly Oxygenated and Rearranged Limonoids from Phyllanthus cochinchinensis 期刊论文
ORGANIC LETTERS, 2013, 卷号: 15, 期号: 10, 页码: 2414-2417
作者:  Zhao, Jian-Qiang;  Wang, Yan-Ming;  He, Hong-Ping;  Li, Sheng-Hong;  Li, Xiao-Nian;  Yang, Chong-Ren;  Wang, Dong;  Zhu, Hong-Tao;  Xu, Min;  Zhang, Ying-Jun
浏览  |  Adobe PDF(620Kb)  |  收藏  |  浏览/下载：452/114  |  提交时间：2013/07/24
Aphanamixis-polystachya  Walsura-cochinchinensis  Blockers  Skeleton  Emblica  Potent  Roots