| Peganumine A, a beta-Carboline Dimer with a New Octacyclic Scaffold from Peganum harmala | |
Wang, Kai-Bo1; Di, Ying-Tong2 ; Bao, Yu3; Yuan, Chun-Mao2; Chen, Gang1; Li, Da-Hong1; Bai, Jiao1; He, Hong-Ping2; Hao, Xiao-Jiang2; Pei, Yue-Hu1; Jing, Yong-Kui4; Li, Zhan-Lin1; Hua, Hui-Ming1; Li, ZL (reprint author), Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China.; lzl1030@hotmail.com; huimhua@163.com
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| 2014-08-01 | |
| 发表期刊 | ORGANIC LETTERS
 |
| ISSN | 1523-7060 |
| 卷号 | 16期号:15页码:4028-4031 |
| 摘要 | Peganumine A (1), a new dimeric beta-carboline alkaloid characterized by a unique 3,9-diazatetracyclo-[6.5.2.0(1,9).0(3,8)]pentadec-2-one scaffold, was isolated from the seeds of Peganum harmala. The structure including the absolute configuration was determined by spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, and HepG2 cells and selective effects on HL-60 cells with an IC50 value of 5.8 mu M. |
| 关键词 | Light-emitting-diodes Alkaloid Extract Potent L. Derivatives Efficiency Toxicity Harmine Cascade Growth |
| 学科领域 | Chemistry, Organic |
| DOI | 10.1021/ol501856v |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000339982300046 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/18271 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Li, ZL (reprint author), Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China.; lzl1030@hotmail.com; huimhua@163.com |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China 4.Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA |
| 推荐引用方式 GB/T 7714 | Wang, Kai-Bo,Di, Ying-Tong,Bao, Yu,et al. Peganumine A, a beta-Carboline Dimer with a New Octacyclic Scaffold from Peganum harmala[J]. ORGANIC LETTERS,2014,16(15):4028-4031. |
| APA | Wang, Kai-Bo.,Di, Ying-Tong.,Bao, Yu.,Yuan, Chun-Mao.,Chen, Gang.,...&huimhua@163.com.(2014).Peganumine A, a beta-Carboline Dimer with a New Octacyclic Scaffold from Peganum harmala.ORGANIC LETTERS,16(15),4028-4031. |
| MLA | Wang, Kai-Bo,et al."Peganumine A, a beta-Carboline Dimer with a New Octacyclic Scaffold from Peganum harmala".ORGANIC LETTERS 16.15(2014):4028-4031. |
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| Wang-2014-Peganumine（295KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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