Li, ZL (reprint author), Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China.
Peganumine A (1), a new dimeric beta-carboline alkaloid characterized by a unique 3,9-diazatetracyclo-[18.104.22.168(1,9).0(3,8)]pentadec-2-one scaffold, was isolated from the seeds of Peganum harmala. The structure including the absolute configuration was determined by spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, and HepG2 cells and selective effects on HL-60 cells with an IC50 value of 5.8 mu M.
1.Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China 4.Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA
Wang,Kai-Bo;Di,Ying-Tong;Bao,Yu;Yuan,Chun-Mao;Chen,Gang;Li,Da-Hong;Bai,Jiao;He,Hong-Ping;Hao,Xiao-Jiang;Pei,Yue-Hu;Jing,Yong-Kui;Li,Zhan-Lin;Hua,Hui-Ming.Peganumine A, a beta-Carboline Dimer with a New Octacyclic Scaffold from Peganum harmala,ORGANIC LETTERS,2014,16(15):4028-4031