Peganumine A, a beta-Carboline Dimer with a New Octacyclic Scaffold from Peganum harmala
Wang, Kai-Bo1; Di, Ying-Tong2; Bao, Yu3; Yuan, Chun-Mao2; Chen, Gang1; Li, Da-Hong1; Bai, Jiao1; He, Hong-Ping2; Hao, Xiao-Jiang2; Pei, Yue-Hu1; Jing, Yong-Kui4; Li, Zhan-Lin1; Hua, Hui-Ming1; Li, ZL (reprint author), Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China.; lzl1030@hotmail.com; huimhua@163.com
2014-08-01
发表期刊ORGANIC LETTERS
ISSN1523-7060
卷号16期号:15页码:4028-4031
摘要

Peganumine A (1), a new dimeric beta-carboline alkaloid characterized by a unique 3,9-diazatetracyclo-[6.5.2.0(1,9).0(3,8)]pentadec-2-one scaffold, was isolated from the seeds of Peganum harmala. The structure including the absolute configuration was determined by spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, and HepG2 cells and selective effects on HL-60 cells with an IC50 value of 5.8 mu M.

关键词Light-emitting-diodes Alkaloid Extract Potent L. Derivatives Efficiency Toxicity Harmine Cascade Growth
资助信息National Natural Science Foundation of China [81172958]; State Key Laboratory of Phytochemistry and Plant Resources in West China [P2012-KF01]
收录类别SCI ; IC
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18271
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Li, ZL (reprint author), Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China.; lzl1030@hotmail.com; huimhua@163.com
作者单位1.Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China
4.Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA
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GB/T 7714
Wang, Kai-Bo,Di, Ying-Tong,Bao, Yu,et al. Peganumine A, a beta-Carboline Dimer with a New Octacyclic Scaffold from Peganum harmala[J]. ORGANIC LETTERS,2014,16(15):4028-4031.
APA Wang, Kai-Bo.,Di, Ying-Tong.,Bao, Yu.,Yuan, Chun-Mao.,Chen, Gang.,...&huimhua@163.com.(2014).Peganumine A, a beta-Carboline Dimer with a New Octacyclic Scaffold from Peganum harmala.ORGANIC LETTERS,16(15),4028-4031.
MLA Wang, Kai-Bo,et al."Peganumine A, a beta-Carboline Dimer with a New Octacyclic Scaffold from Peganum harmala".ORGANIC LETTERS 16.15(2014):4028-4031.
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