(+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3
Luo, Qi1,2; Wang, Zhen3; Luo, Jin-Feng3; Tu, Zheng-Chao3; Cheng, Yong-Xian1,4
2017
发表期刊RSC ADVANCES
ISSN2046-2069
卷号7期号:60页码:38037-38043
摘要Applanatumines B-D (1-3), three pairs of dimeric meroterpenoid enantiomers featuring the presence of a 6-oxo-4,4a, 5,5a, 6,8,8a, 8b-octahydrofuro[3',4':4,5] cyclopenta[1,2-b] pyran-3-carbaldehyde structure core, were isolated from the fruiting bodies of Ganoderma applanatum. Their structures and absolute configurations were assigned by using spectroscopic methods and ECD calculations. Biological evaluation found that all the compounds are JAK3 inhibitors. In addition, the enantiomers of 1 are active towards DDR1 with IC50 values of 8.2 + 0.8 mu M and 6.9 + 0.8 mu M. Finally, a plausible biogenic pathway for compounds 1-3 was proposed.
关键词(+/-)-lingzhiol Biosynthesis Lucidum Potent Ddr1
学科领域Chemistry, Multidisciplinary
DOI10.1039/c7ra04862a
收录类别SCI
语种英语
WOS记录号WOS:000407305200066
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/54979
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Yuquan Rd 19, Beijing 100049, Peoples R China
3.Guangzhou Inst Biomed & Hlth, Guangdong Prov Key Lab Biocomp, Drug Discovery Pipeline, Guangzhou 510530, Guangdong, Peoples R China
4.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Shenzhen 518060, Peoples R China
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Luo, Qi,Wang, Zhen,Luo, Jin-Feng,et al. (+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3[J]. RSC ADVANCES,2017,7(60):38037-38043.
APA Luo, Qi,Wang, Zhen,Luo, Jin-Feng,Tu, Zheng-Chao,&Cheng, Yong-Xian.(2017).(+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3.RSC ADVANCES,7(60),38037-38043.
MLA Luo, Qi,et al."(+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3".RSC ADVANCES 7.60(2017):38037-38043.
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