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题名: (+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3
作者: Luo,Qi; Wang,Zhen; Luo,Jin-Feng; Tu,Zheng-Chao; Cheng,Yong-Xian
刊名: RSC ADVANCES
关键词: (+/-)-LINGZHIOL ; BIOSYNTHESIS ; LUCIDUM ; POTENT ; DDR1
英文摘要: Applanatumines B-D (1-3), three pairs of dimeric meroterpenoid enantiomers featuring the presence of a 6-oxo-4,4a, 5,5a, 6,8,8a, 8b-octahydrofuro[3',4':4,5] cyclopenta[1,2-b] pyran-3-carbaldehyde structure core, were isolated from the fruiting bodies of Ganoderma applanatum. Their structures and absolute configurations were assigned by using spectroscopic methods and ECD calculations. Biological evaluation found that all the compounds are JAK3 inhibitors. In addition, the enantiomers of 1 are active towards DDR1 with IC50 values of 8.2 + 0.8 mu M and 6.9 + 0.8 mu M. Finally, a plausible biogenic pathway for compounds 1-3 was proposed.
出版日期: 2017
卷号: 7, 期号:60, 页码:38037-38043
DOI标识: 10.1039/c7ra04862a
语种: 英语
收录类别: SCI
学科分类: Chemistry, Multidisciplinary
通讯作者邮箱: tu_zhengchao@gibh.ac.cn ; yxcheng@mail.kib.ac.cn
ISSN号: 2046-2069
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/54979
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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Recommended Citation:
Luo,Qi,Wang,Zhen,Luo,Jin-Feng,et al. (+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3[J]. RSC ADVANCES,2017,7(60):38037-38043.
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