| (+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3 | |
Luo, Qi1,2 ; Wang, Zhen3; Luo, Jin-Feng3; Tu, Zheng-Chao3; Cheng, Yong-Xian1,4
| |
| 2017 | |
| 发表期刊 | RSC ADVANCES
 |
| ISSN | 2046-2069 |
| 卷号 | 7期号:60页码:38037-38043 |
| 摘要 | Applanatumines B-D (1-3), three pairs of dimeric meroterpenoid enantiomers featuring the presence of a 6-oxo-4,4a, 5,5a, 6,8,8a, 8b-octahydrofuro[3',4':4,5] cyclopenta[1,2-b] pyran-3-carbaldehyde structure core, were isolated from the fruiting bodies of Ganoderma applanatum. Their structures and absolute configurations were assigned by using spectroscopic methods and ECD calculations. Biological evaluation found that all the compounds are JAK3 inhibitors. In addition, the enantiomers of 1 are active towards DDR1 with IC50 values of 8.2 + 0.8 mu M and 6.9 + 0.8 mu M. Finally, a plausible biogenic pathway for compounds 1-3 was proposed. |
| 关键词 | (+/-)-lingzhiol Biosynthesis Lucidum Potent Ddr1 |
| 学科领域 | Chemistry, Multidisciplinary |
| DOI | 10.1039/c7ra04862a |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000407305200066 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/54979 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19, Beijing 100049, Peoples R China 3.Guangzhou Inst Biomed & Hlth, Guangdong Prov Key Lab Biocomp, Drug Discovery Pipeline, Guangzhou 510530, Guangdong, Peoples R China 4.Shenzhen Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Shenzhen 518060, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Qi,Wang, Zhen,Luo, Jin-Feng,et al. (+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3[J]. RSC ADVANCES,2017,7(60):38037-38043. |
| APA | Luo, Qi,Wang, Zhen,Luo, Jin-Feng,Tu, Zheng-Chao,&Cheng, Yong-Xian.(2017).(+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3.RSC ADVANCES,7(60),38037-38043. |
| MLA | Luo, Qi,et al."(+/-)-Applanatumines B-D: novel dimeric meroterpenoids from Ganoderma applanatum as inhibitors of JAK3".RSC ADVANCES 7.60(2017):38037-38043. |
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| luo2017.pdf（795KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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