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Small-Molecule Drugs in Immunotherapy 期刊论文
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2023, 卷号: 23, 期号: 13, 页码: 1341-1359
作者:  Hao,Xuanrun;  Chen,Zhongliang;  Li,Haining;  Wei,Minqin;  Zuo,Zhili;  Su,Qing
浏览  |  Adobe PDF(29350Kb)  |  收藏  |  浏览/下载：34/5  |  提交时间：2024/07/25
Cancer immunotherapy  inhibitors  Pd-1/Pd-L1 inhibitor  IDO inhibitor  STING agonists  ROR gamma t agonists  TGF  beta inhibitors  INDOLEAMINE 2,3-DIOXYGENASE  SIGNALING INHIBITOR  DENDRITIC CELLS  GROWTH  TUMOR  PATHWAY  PEMBROLIZUMAB  RECEPTORS  DISCOVERY  VADIMEZAN  
The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid β-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions 期刊论文
JOURNAL OF FUNCTIONAL FOODS, 2023, 卷号: 107, 页码: 105607
作者:  Yang,Mei-Xia;  Cheng,Edwin Hok-Chi;  Ospondpant,Dusadee;  Tung,Ka-Ki;  Wang,Li-Song;  Lin,Sheng-Ying;  Lai,Queenie Wing-Sze;  Wu,Qi-Yun;  Xia,Ying-Jie;  Leung,Ka-Wing;  Duan,Ran;  Dong,Tina Ting-Xia;  Tsim,Karl Wah-Keung
浏览  |  Adobe PDF(4569Kb)  |  收藏  |  浏览/下载：42/9  |  提交时间：2024/07/25
Alzheimer's disease  Inflammation  Fibrillar A beta  Lichen  Lobaria pindarensis  Depsidone  IN-SILICO  IDENTIFICATION  INHIBITORS  
Synthesis and biological evaluation of (20S,24R)-epoxy-dammarane-3 beta,12 beta,25-triol derivatives as alpha-glucosidase and PTP1B inhibitors 期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2022, 卷号: 31, 期号: 2, 页码: 350-367
作者:  Yang, Xiao-Tong;  Li, Tian-Ze;  Geng, Chang-An;  Liu, Pei;  Chen, Ji-Jun
浏览  |  Adobe PDF(1348Kb)  |  收藏  |  浏览/下载：74/15  |  提交时间：2024/04/30
(20S,24R)-epoxy-dammarane-3 beta,12 beta,25-triol  alpha-glucosidase inhibitors  PTP1B inhibitors  Enzyme kinetics  TYROSINE-PHOSPHATASE 1B  DIABETES-MELLITUS  EPIDEMIOLOGY  
Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11 beta-HSD1 inhibitors: Potential impact in diabetes 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 65, 页码: 403-414
作者:  Deng, Xu;  Shen, Yu;  Yang, Jing;  He, Juan;  Zhao, Yu;  Peng, Li-Yan;  Leng, Ying;  Zhao, Qin-Shi
浏览  |  Adobe PDF(1215Kb)  |  收藏  |  浏览/下载：451/162  |  提交时间：2013/10/16
Ent-kaurene Diterpenoids  Structure-activity Relationship Studies  Selective 11 Beta-hsd1 Inhibitors  Urea Derivatives  Diabetes  
Dual Carbamoylations on the Polyketide and Glycosyl Moiety by Asm21 Result in Extended Ansamitocin Biosynthesis 期刊论文
CHEMISTRY & BIOLOGY, 2011, 卷号: 18, 期号: 12, 页码: 1571-1580
作者:  Li, Yan;  Zhao, Peiji;  Kang, Qianjin;  Ma, Juan;  Bai, Linquan;  Deng, Zixin
浏览  |  Adobe PDF(986Kb)  |  收藏  |  浏览/下载：410/113  |  提交时间：2012/07/25
Antitumor Agent Ansamitocin  Beta-lactam Antibiotics  Actinosynnema-pretiosum  Gene-cluster  Dna Gyrase  Concanamycin-a  Streptomyces  Novobiocin  Carbamoyltransferase  Inhibitors