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Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RAR alpha-PPAR gamma-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice 期刊论文
NUTRIENTS, 2022, 卷号: 14, 期号: 12, 页码: 2411
作者:  Zhao, Zhuohui;  Deng, Zhen-Tao;  Huang, Suling;  Ning, Mengmeng;  Feng, Ying;  Shen, Yu;  Zhao, Qin-Shi;  Leng, Ying
浏览  |  Adobe PDF(6451Kb)  |  收藏  |  浏览/下载：261/53  |  提交时间：2024/04/30
Alisol B  non-alcoholic steatohepatitis  RAR alpha  CD36  FATTY LIVER  HEPATIC STEATOSIS  RECEPTOR  ORIENTALE  LIPOPROTEINS  23-ACETATE  AGONIST  CD36  
Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway 期刊论文
MOLECULAR METABOLISM, 2020
作者:  Liu, Siwen;  Huang, Suling;  Wu, Xingde;  Feng, Ying;  Shen, Yu;  Zhao, Qin-shi;  Leng, Ying
浏览  |  Adobe PDF(3899Kb)  |  收藏  |  浏览/下载：264/62  |  提交时间：2021/01/05
Synthesis of selective 11 beta-HSD1 inhibitors based on dammarane scaffold 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 135, 页码: 324-338
作者:  Shao, Li-Dong;  Bao, Ying;  Shen, Yu;  Su, Jia;  Leng, Ying;  Zhao, Qin-Shi
浏览  |  Adobe PDF(1336Kb)  |  收藏  |  浏览/下载：461/124  |  提交时间：2017/07/31
11 Beta-hsd1 Inhibitor  Hupehenols  Dammarane  Sar  
Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2015, 卷号: 78, 期号: 2, 页码: 330-334
作者:  Chen, Xuan-Qin;  Shao, Li-Dong;  Pal, Mahesh;  Shen, Yu;  Cheng, Xiao;  Xu, Gang;  Peng, Li-Yan;  Wang, Kou;  Pan, Zheng-Hong;  Li, Ming-Ming;  Leng, Ying;  He, Juan;  Zhao, Qin-Shi;  He,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Yunnan,Peoples R China.;  hejuan@mail.kib.ac.cn;  qinshizhao@mail.kib.ac.cn
浏览  |  Adobe PDF(811Kb)  |  收藏  |  浏览/下载：449/126  |  提交时间：2015/06/29
Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11 beta-HSD1 inhibitors: Potential impact in diabetes 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 65, 页码: 403-414
作者:  Deng, Xu;  Shen, Yu;  Yang, Jing;  He, Juan;  Zhao, Yu;  Peng, Li-Yan;  Leng, Ying;  Zhao, Qin-Shi
浏览  |  Adobe PDF(1215Kb)  |  收藏  |  浏览/下载：527/169  |  提交时间：2013/10/16
Ent-kaurene Diterpenoids  Structure-activity Relationship Studies  Selective 11 Beta-hsd1 Inhibitors  Urea Derivatives  Diabetes  
Cycloartane and Friedelane Triterpenoids from the Leaves of Caloncoba glauca and Their Evaluation for Inhibition of 11 beta-Hydroxysteroid Dehydrogenases 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2012, 卷号: 75, 期号: 4, 页码: 599-604
作者:  Mpetga, James D. Simo;  Shen, Yu;  Tane, Pierre;  Li, Shi-Fei;  He, Hong-Ping;  Wabo, Hippolyte K.;  Tene, Mathieu;  Leng, Ying;  Hao, Xiao-Jiang
Adobe PDF(347Kb)  |  收藏  |  浏览/下载：552/174  |  提交时间：2012/06/07
Cimicifuga Foetida  4 Alpha-methyl Steroid  Cytotoxicity  Cimisterol a  Performance Liquid-chromatography  Light-scattering Detection  Black Cohosh Products  Euphorbia-chamaesyce  Sequence Variation  Actaea-racemosa  Whole Herb  Triterpenoids  Constituents  Identification  
Pseudoferic acids A-C, three novel triterpenoids from the root bark of Pseudolarix kaempferi 期刊论文
TETRAHEDRON LETTERS, 2012, 卷号: 53, 期号: 7, 页码: 800-803
作者:  Wu, Xing-De;  He, Juan;  Shen, Yu;  Dong, Liao-Bin;  Pan, Zheng-Hong;  Xu, Gang;  Gong, Xun;  Song, Liu-Dong;  Leng, Ying;  Li, Yan;  Peng, Li-Yan;  Zhao, Qin-Shi
Adobe PDF(380Kb)  |  收藏  |  浏览/下载：871/157  |  提交时间：2012/06/07
Pseudolarix Kaempferi  Triterpenoids  11 Beta-hsd1 Inhibitory Activity  
Cyclopeptide Alkaloids from Ziziphus apetala 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2011, 卷号: 74, 期号: 12, 页码: 2571-2575
作者:  Han, Jing;  Ji, Chang-Jiu;  He, Wen-Jun;  Shen, Yu;  Leng, Ying;  Xu, Wen-Yan;  Fan, Jun-Ting;  Zeng, Guang-Zhi;  Kong, Ling-Dong;  Tan, Ning-Hua
Adobe PDF(213Kb)  |  收藏  |  浏览/下载：566/187  |  提交时间：2012/04/10
丹参酮衍生物,其药物组合物及其在制药中的应用 专利
申请日期: 2011-07-02, 公开日期: 2012-01-04
发明人:  赵勤实;  冷颖;  赵昱;  邓旭;  沈瑜;  张丽娜
收藏  |  浏览/下载：185/0  |  提交时间：2018/05/10
Rare merosesquiterpenoids from basidiomycete Craterellus odoratus and their inhibition of 11 beta-hydroxysteroid dehydrogenases 期刊论文
PHYTOCHEMISTRY, 2010, 卷号: 71, 期号: 1, 页码: 100-103
作者:  Zhang, Ling;  Shen, Yu;  Wang, Fei;  Leng, Ying;  Liu, Ji-Kai
Adobe PDF(179Kb)  |  收藏  |  浏览/下载：437/115  |  提交时间：2011/11/24
Craterellus Odoratus  Basidiomycete  Epoxymethylenecyclohexanetriol-bicyclofarnesane  Merosesquiterpenoids  Craterellins A-c