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中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
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0.05). For some populations, germination capacity in 12-h photoperiod was significantly higher than that in completed darkness(W-FD: P < 0.01, W-JD: P < 0.05).Genetic variation within and among six populations was assessed using AFLP markers. Genetic diversity was higher at species level (PPL = 69.19%, HE = 0.221) than at population level (PPL = 26.22%, HE = 0.095, Is =0.140), and populations in southeast Yunnan were strongly differentiated from those in southwest Yunnan (Nei’s GST = 0.575; FST = 0.655). UPGMA analysis demonstrated a clear genetic division between the two populations from DeHong (SW Yunnan; D-JD and D-HG) and the four from WenShan (SE Yunnan; W-FD, W-LH, W-ML, and W-MG). Within-population genetic variation was significantly correlated with population isolation (r(PPL) = -0.94, P = 0.006; r(HE) = -0.85, P = 0.032; r(Is) = -0.87, P = 0.025), but not with population size (r(PPL) = 0.63, P = 0.178; r(HE) = 0.54, P = 0.268; r(Is) = 0.56, P = 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Science Foundation[15-23242S]","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=Mortality&order=desc&&fq=dc.project.title_filter%3ACzech%5C+Science%5C+Foundation%5C%5B15%5C-23242S%5C%5D"},{"jsname":"Czech Science Foundation[16-26369S]","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=Mortality&order=desc&&fq=dc.project.title_filter%3ACzech%5C+Science%5C+Foundation%5C%5B16%5C-26369S%5C%5D"},{"jsname":"European Union (EC 7th Framework Program)[608422]","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=Mortality&order=desc&&fq=dc.project.title_filter%3AEuropean%5C+Union%5C+%5C%28EC%5C+7th%5C+Framework%5C+Program%5C%29%5C%5B608422%5C%5D"},{"jsname":"Fundamental Research Funds for the Central Universities[17l-gzd24]","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=Mortality&order=desc&&fq=dc.project.title_filter%3AFundamental%5C+Research%5C+Funds%5C+for%5C+the%5C+Central%5C+Universities%5C%5B17l%5C-gzd24%5C%5D"},{"jsname":"German Research Foundation[DFG FOR 891]","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=Mortality&order=desc&&fq=dc.project.title_filter%3AGerman%5C+Research%5C+Foundation%5C%5BDFG%5C+FOR%5C+891%5C%5D"},{"jsname":"In order to investigate the bio-diversity of chemical constituents in Cimicifuga foetida L. from Southwest China, to explore the constituents with anti-cancer activity in Traditional Chinese Medicine Cimicifugae Rhizomes, we analyzed the chemical constiturents from the rhizomes of C. foetida L. collected from Sichuan, Guizhou and Yunnan. The in vitro and in vivo test were also carried out. We will discuss about the research thoroughly in this Ph. D. dissertation. The dissertation contains three chapters. The phytochemical studies of four Cimicifuga foetida L. from different habitat in Southwest China are discussed in Chapter 1-The Chemical Constituents of Cimicifuga foetida L. from Different Habitat in Southwest China. The separation and identification of 57 compounds including 22 new ones from C. foetida L.were written in detail. Among the new compounds, there are 20 triterpenoids, most of which are cycloartane type, one 2-quinolone based compound and a chrome glycoside. A series of triterpenen bisglycosides with free side chain were isolated from the n-BuOH portion of Cimicifuga foetida L. from Lijiang, which haven’t had any report in this genus before. Chapter 2-Inhibitory Effect of Constituents in Cimicifuga foetida L. on Cancer deals with the results of anti-cancer assay of compounds from Cimicifuga foetida L., most of which are new compounds. The results indicated the compounds with cytotoxicity focalized in a part with paticular polarity. Besides, inhibitory effect of two main constituents of C. foetida L., Actein and 23-epi-26-deoxyactein, on immunodeficiency nu/nu mice carrying human breast cancer BCap-37 tumers were studied. Their inhibitory effects were even stronger than the positive control tamoxifen [Tumor Inhibitory rate (%):57.7 (A: 9 mg/kg) & 54.8 (DA: 27 mg/kg) vs 33.6 (TAM: 2 mg/kg)].Chapter 3-Review of pharmacological studies on Cimicifuga and its constituents in the decade is an review of pharmacological studies about extracts and compounds in Cimicifuga genus in the decade. There are reports of activities of anticancer, menopausal syndrome amelioration, antiosteoporosis, anti-inflammatory, immunosupression on extracts, triterpenoids, cinnamic derivatives and a 5-HT derivative of Cimicifuga genus. The results indicated that the major triterpenoids constituents in C. foetida L. is stable, especially the triterpenoids with the midium polarity, whereas the compounds yielded from the small and large polarity change due to the different habitat. Fortunately, the anti-cancer triterpenoids assemble in the stable midium polarity part. We can extract them for the better treatment in the future.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=Mortality&order=desc&&fq=dc.project.title_filter%3AIn%5C+order%5C+to%5C+investigate%5C+the%5C+bio%5C-diversity%5C+of%5C+chemical%5C+constituents%5C+in%5C+Cimicifuga%5C+foetida%5C+L.%5C+from%5C+Southwest%5C+China%2C%5C+to%5C+explore%5C+the%5C+constituents%5C+with%5C+anti%5C-cancer%5C+activity%5C+in%5C+Traditional%5C+Chinese%5C+Medicine%5C+Cimicifugae%5C+Rhizomes%2C%5C+we%5C+analyzed%5C+the%5C+chemical%5C+constiturents%5C+from%5C+the%5C+rhizomes%5C+of%5C+C.%5C+foetida%5C+L.%5C+collected%5C+from%5C+Sichuan%2C%5C+Guizhou%5C+and%5C+Yunnan.%5C+The%5C+in%5C+vitro%5C+and%5C+in%5C+vivo%5C+test%5C+were%5C+also%5C+carried%5C+out.%5C+We%5C+will%5C+discuss%5C+about%5C+the%5C+research%5C+thoroughly%5C+in%5C+this%5C+Ph.%5C+D.%5C+dissertation.%5C+The%5C+dissertation%5C+contains%5C+three%5C+chapters.%5C+The%5C+phytochemical%5C+studies%5C+of%5C+four%5C+Cimicifuga%5C+foetida%5C+L.%5C+from%5C+different%5C+habitat%5C+in%5C+Southwest%5C+China%5C+are%5C+discussed%5C+in%5C+Chapter%5C+1%5C-The%5C+Chemical%5C+Constituents%5C+of%5C+Cimicifuga%5C+foetida%5C+L.%5C+from%5C+Different%5C+Habitat%5C+in%5C+Southwest%5C+China.%5C+The%5C+separation%5C+and%5C+identification%5C+of%5C+57%5C+compounds%5C+including%5C+22%5C+new%5C+ones%5C+from%5C+C.%5C+foetida%5C+L.were%5C+written%5C+in%5C+detail.%5C+Among%5C+the%5C+new%5C+compounds%2C%5C+there%5C+are%5C+20%5C+triterpenoids%2C%5C+most%5C+of%5C+which%5C+are%5C+cycloartane%5C+type%2C%5C+one%5C+2%5C-quinolone%5C+based%5C+compound%5C+and%5C+a%5C+chrome%5C+glycoside.%5C+A%5C+series%5C+of%5C+triterpenen%5C+bisglycosides%5C+with%5C+free%5C+side%5C+chain%5C+were%5C+isolated%5C+from%5C+the%5C+n%5C-BuOH%5C+portion%5C+of%5C+Cimicifuga%5C+foetida%5C+L.%5C+from%5C+Lijiang%2C%5C+which%5C+haven%E2%80%99t%5C+had%5C+any%5C+report%5C+in%5C+this%5C+genus%5C+before.%5C+Chapter%5C+2%5C-Inhibitory%5C+Effect%5C+of%5C+Constituents%5C+in%5C+Cimicifuga%5C+foetida%5C+L.%5C+on%5C+Cancer%5C+deals%5C+with%5C+the%5C+results%5C+of%5C+anti%5C-cancer%5C+assay%5C+of%5C+compounds%5C+from%5C+Cimicifuga%5C+foetida%5C+L.%2C%5C+most%5C+of%5C+which%5C+are%5C+new%5C+compounds.%5C+The%5C+results%5C+indicated%5C+the%5C+compounds%5C+with%5C+cytotoxicity%5C+focalized%5C+in%5C+a%5C+part%5C+with%5C+paticular%5C+polarity.%5C+Besides%2C%5C+inhibitory%5C+effect%5C+of%5C+two%5C+main%5C+constituents%5C+of%5C+C.%5C+foetida%5C+L.%2C%5C+Actein%5C+and%5C+23%5C-epi%5C-26%5C-deoxyactein%2C%5C+on%5C+immunodeficiency%5C+nu%5C%2Fnu%5C+mice%5C+carrying%5C+human%5C+breast%5C+cancer%5C+BCap%5C-37%5C+tumers%5C+were%5C+studied.%5C+Their%5C+inhibitory%5C+effects%5C+were%5C+even%5C+stronger%5C+than%5C+the%5C+positive%5C+control%5C+tamoxifen%5C+%5C%5BTumor%5C+Inhibitory%5C+rate%5C+%5C%28%25%5C%29%EF%BC%9A57.7%5C+%5C%28A%5C%3A%5C+9%5C+mg%5C%2Fkg%5C%29%5C+%5C%26%5C+54.8%5C+%5C%28DA%5C%3A%5C+27%5C+mg%5C%2Fkg%5C%29%5C+vs%5C+33.6%5C+%5C%28TAM%5C%3A%5C+2%5C+mg%5C%2Fkg%5C%29%5C%5D.Chapter%5C+3%5C-Review%5C+of%5C+pharmacological%5C+studies%5C+on%5C+Cimicifuga%5C+and%5C+its%5C+constituents%5C+in%5C+the%5C+decade%5C+is%5C+an%5C+review%5C+of%5C+pharmacological%5C+studies%5C+about%5C+extracts%5C+and%5C+compounds%5C+in%5C+Cimicifuga%5C+genus%5C+in%5C+the%5C+decade.%5C+There%5C+are%5C+reports%5C+of%5C+activities%5C+of%5C+anticancer%2C%5C+menopausal%5C+syndrome%5C+amelioration%2C%5C+antiosteoporosis%2C%5C+anti%5C-inflammatory%2C%5C+immunosupression%5C+on%5C+extracts%2C%5C+triterpenoids%2C%5C+cinnamic%5C+derivatives%5C+and%5C+a%5C+5%5C-HT%5C+derivative%5C+of%5C+Cimicifuga%5C+genus.%5C+The%5C+results%5C+indicated%5C+that%5C+the%5C+major%5C+triterpenoids%5C+constituents%5C+in%5C+C.%5C+foetida%5C+L.%5C+is%5C+stable%2C%5C+especially%5C+the%5C+triterpenoids%5C+with%5C+the%5C+midium%5C+polarity%2C%5C+whereas%5C+the%5C+compounds%5C+yielded%5C+from%5C+the%5C+small%5C+and%5C+large%5C+polarity%5C+change%5C+due%5C+to%5C+the%5C+different%5C+habitat.%5C+Fortunately%2C%5C+the%5C+anti%5C-cancer%5C+triterpenoids%5C+assemble%5C+in%5C+the%5C+stable%5C+midium%5C+polarity%5C+part.%5C+We%5C+can%5C+extract%5C+them%5C+for%5C+the%5C+better%5C+treatment%5C+in%5C+the%5C+future."},{"jsname":"Light of the West Talent Cultivation Program of Chinese Academy of Sciences[201684]","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=Mortality&order=desc&&fq=dc.project.title_filter%3ALight%5C+of%5C+the%5C+West%5C+Talent%5C+Cultivation%5C+Program%5C+of%5C+Chinese%5C+Academy%5C+of%5C+Sciences%5C%5B201684%5C%5D"},{"jsname":"Mushroom Research Foundation","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=Mortality&order=desc&&fq=dc.project.title_filter%3AMushroom%5C+Research%5C+Foundation"},{"jsname":"NSFC[U1602264]","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=Mortality&order=desc&&fq=dc.project.title_filter%3ANSFC%5C%5BU1602264%5C%5D"},{"jsname":"lastIndexed","jscount":"2024-05-24"}],"资助项目","dc.project.title_filter")'>
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The compound BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase1
期刊论文
出版物, 3111, 期号: 0, 页码: 1-38
作者:
Fabrice Ivanes
;
Danilo Faccenda
;
Jemma Gatliff
;
Ahmed A Ahmed
;
Stefania Cocco
;
Carol Ho Ka Cheng
;
Emma Allan
;
Claire Russell
;
Michael R Duchen
;
Michelangelo Campanella
Adobe PDF(1228Kb)
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浏览/下载:223/1
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提交时间:2017/07/24
Mitochondrial F1fo Atp Synthase
If1
Ischemia-induced Death
Btb06584
Pinotage
Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase-9 through modulation of NF-B and AP-1 activity in human liver cancer cells lines
期刊论文
出版物, 3111, 期号: 0, 页码: 1—28
作者:
Ming-Ju Hsieh
;
Chiao-Wen Lin
;
Shun-Fa Yang
;
Mu-Kuan Chen
;
Hui-Ling Chiou
Adobe PDF(1320Kb)
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浏览/下载:183/1
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提交时间:2017/07/24
Glabridin
Migration
Invasion
Matrix Metalloproteinase-9
Hepatoma
Olmesartan prevents cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and P53
期刊论文
出版物, 3111, 期号: 0, 页码: 1-37
作者:
Baihe Chen
;
Di Lu
;
Yujuan Fu
;
Jingwen Zhang
;
Xiaobo Huang
;
Shiping Cao
;
Dingli Xu
;
Jianping Bin
;
Masafumi Kitakaze
;
Qiaobing Huang
;
Yulin Liao
Adobe PDF(1769Kb)
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浏览/下载:286/1
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提交时间:2017/07/24
Cardiac Rupture
Olmesartan
P53
Gdf-15
Aldosterone
Myocardial Infarction
Evolutionary ecology of plant-plant interactions
期刊论文
出版物, 3111, 页码: 1-144
作者:
Zuo Z(作者)
Adobe PDF(717Kb)
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提交时间:2017/07/19
Reproductive Allocation in Plants
期刊论文
Reproductive Allocation in Plants, 3111, 页码: 1—30
作者:
Shuhei Tanaka
;
Shin-ichiro Kochi
;
Heigo Kunita
;
Shin-ichi Ito
;
Mitsuro Kameya-Iwaki
Adobe PDF(180Kb)
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提交时间:2017/07/19
YC-1 inhibits proliferation of breast cancer cells by downregulating EZH2 expression via activation of c-Cbl and ERK
期刊论文
出版物, 3111, 期号: 0, 页码: 1-46
作者:
Ling-Chu Chang
;
Hui-Yi Lin
;
Meng-Tung Tsai
;
Ruey-Hwang Chou
;
Fang-Yu Lee
;
Che-Ming Teng
;
Min-Tsang Hsieh
;
Hsin-Yi Hung
;
Li-Jiau Huang
;
Yung-Luen Yu
;
Sheng-Chu Kuo
Adobe PDF(1357Kb)
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提交时间:2017/07/24
Yc-1
Triple-negative Breast Cancer
Erk
Ezh2
C-cbl
The pharmacokinetics of anthocyanins and their metabolites in humans
期刊论文
出版物, 3111, 期号: 0, 页码: 1-37
作者:
R M de Ferrars
;
C Czank
;
Q Zhang
;
N P Botting
;
P A Kroon
;
A Cassidy
;
C D Kay
Adobe PDF(1873Kb)
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浏览/下载:140/1
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提交时间:2017/07/24
Anthocyanins
Metabolites
Hippuric Acid
Ferulic Acid
Vanillic Acid
Degeneration of foundation cushion species induced by ecological constraints can cause massive changes in alpine plant communities
期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2024, 卷号: 67, 期号: 3, 页码: 596-610
作者:
Chen, Jianguo
;
Chen, Xufang
;
Qian, Lishen
;
Zhang, Yazhou
;
Li, Bo
;
Shi, Honghua
;
Sun, Lu
;
Schob, Christian
;
Sun, Hang
Adobe PDF(2734Kb)
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浏览/下载:19/5
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提交时间:2024/05/09
alpine ecosystem
biodiversity change
climate change
plant community dynamics
foundation species
global warming
population dynamics
QINGHAI-TIBET PLATEAU
ECOSYSTEM ENGINEERS
HENGDUAN MOUNTAINS
ARENARIA-POLYTRICHOIDES
RANGE SHIFTS
CLIMATE
DIVERSITY
CONSEQUENCES
RECRUITMENT
VEGETATION
RUNX1-Regulated Signaling Pathways in Ovarian Cancer
期刊论文
BIOMEDICINES, 2023, 卷号: 11, 期号: 9, 页码: 2357
作者:
Chen,Yuanzhi
;
He,Yingying
;
Liu,Shubai
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提交时间:2024/05/09
Runt-related transcription factor 1 (RUNX1)
ovarian cancer
apoptosis
signaling pathways
clinical therapeutic target
GROWTH-FACTOR
TRANSCRIPTION FACTORS
STEM-CELLS
RUNX1
STAT3
FAMILY
ACTIVATION
APOPTOSIS
LEUKEMIA
SURVIVAL
多花蒿中流份 B 和 E 的抗肝癌活性成分研究
学位论文
: 中国科学院大学, 2022
作者:
张鑫
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提交时间:2024/05/14
多花蒿,多花蒿素 A~L,吉玛烷型倍半萜,抗肝癌细胞毒活性
Artemisia myriantha, artemyrianosins A~L, germacrane sesquiterpenoids, antihepatoma activity