RUNX1-Regulated Signaling Pathways in Ovarian Cancer

doi:10.3390/biomedicines11092357

KIB OpenIR

	RUNX1-Regulated Signaling Pathways in Ovarian Cancer
	Chen,Yuanzhi; He,Yingying; Liu,Shubai
	2023
发表期刊	BIOMEDICINES
ISSN	2227-9059
卷号	11 期号:9 页码:2357
摘要	Ovarian cancer is the leading cause of gynecological death worldwide, and its poor prognosis and high mortality seriously affect the life of ovarian cancer patients. Runt-related transcription factor 1 (RUNX1) has been widely studied in hematological diseases and plays an important role in the occurrence and development of hematological diseases. In recent years, studies have reported the roles of RUNX1 in solid tumors, including the significantly increased expression of RUNX1 in ovarian cancer. In ovarian cancer, the dysregulation of the RUNX1 signaling pathway has been implicated in tumor progression, metastasis, and response to therapy. At the same time, the decreased expression of RUNX1 in ovarian cancer can significantly improve the sensitivity of clinical chemotherapy and provide theoretical support for the subsequent diagnosis and treatment target of ovarian cancer, providing prognosis and treatment options to patients with ovarian cancer. However, the role of RUNX1 in ovarian cancer remains unclear. Therefore, this article reviews the relationship between RUNX1 and the occurrence and development of ovarian cancer, as well as the closely regulated signaling pathways, to provide some inspiration and theoretical support for future research on RUNX1 in ovarian cancer and other diseases.
关键词	Runt-related transcription factor 1 (RUNX1) ovarian cancer apoptosis signaling pathways clinical therapeutic target GROWTH-FACTOR TRANSCRIPTION FACTORS STEM-CELLS RUNX1 STAT3 FAMILY ACTIVATION APOPTOSIS LEUKEMIA SURVIVAL
DOI	10.3390/biomedicines11092357
WOS记录号	WOS:001071292900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74995
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Chen,Yuanzhi,He,Yingying,Liu,Shubai. RUNX1-Regulated Signaling Pathways in Ovarian Cancer[J]. BIOMEDICINES,2023,11(9):2357.
APA	Chen,Yuanzhi,He,Yingying,&Liu,Shubai.(2023).RUNX1-Regulated Signaling Pathways in Ovarian Cancer.BIOMEDICINES,11(9),2357.
MLA	Chen,Yuanzhi,et al."RUNX1-Regulated Signaling Pathways in Ovarian Cancer".BIOMEDICINES 11.9(2023):2357.

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