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Nociceptin/Orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of PTSD 期刊论文
出版物, 3111, 期号: 0, 页码: 1-33
作者:  Y Zhang;  C D Simpson-Durand;  K M Standifer
Adobe PDF(1098Kb)  |  收藏  |  浏览/下载:156/1  |  提交时间:2017/07/24
High-content screening of diterpenoids from Isodon species as autophagy modulators and the functional study of their antiviral activities 期刊论文
CELL BIOLOGY AND TOXICOLOGY, 2021, 卷号: 37, 期号: 5, 页码: 695-713
作者:  Huang,Lihong;  Fu,Qiang;  Dai,Jia-Meng;  Yan,Bing-Chao;  Wang,Dawei;  Puno,Pema-Tenzin;  Yue,Jianbo
浏览  |  Adobe PDF(10840Kb)  |  收藏  |  浏览/下载:162/23  |  提交时间:2022/04/02
Diterpenoids  Autophagy  Lysosome  Autophagosome  Enanderinanin J  Dengue virus (DENV)  Zika virus (ZIKV)  Japanese encephalitis virus (JEV)  Enterovirus-A71 (EV-A71)  
The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020
作者:  Xu, Guowei;  Yang, Yaqing;  Yang, Yanming;  Song, Gao;  Li, Shanshan;  Zhang, Jiajun;  Yang, Weimin;  Wang, Liang-Liang;  Weng, Zhiying;  Zuo, Zhili
浏览  |  Adobe PDF(2526Kb)  |  收藏  |  浏览/下载:126/29  |  提交时间:2021/01/05
Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway 期刊论文
MOLECULAR METABOLISM, 2020
作者:  Liu, Siwen;  Huang, Suling;  Wu, Xingde;  Feng, Ying;  Shen, Yu;  Zhao, Qin-shi;  Leng, Ying
浏览  |  Adobe PDF(3899Kb)  |  收藏  |  浏览/下载:124/34  |  提交时间:2021/01/05
两种西藏产唇形科植物的次生代谢产物及生物活性研究 学位论文
博士: 中国科学院昆明植物研究所, 2019
作者:  冯玲
Adobe PDF(3319Kb)  |  收藏  |  浏览/下载:204/1  |  提交时间:2022/08/29
唇形科  米团花  鸡骨柴  次生代谢产物  生物活性  
腺苷酸环化酶亚型选择性小分子激动剂的筛选模型建立及应用 学位论文
硕士: 中国科学院昆明植物研究所, 2019
作者:  徐国伟
Adobe PDF(5623Kb)  |  收藏  |  浏览/下载:46/0  |  提交时间:2022/08/29
腺苷酸环化酶2  腺苷酸环化酶8  选择性激动剂  虚拟筛选  分子对接和动力学模拟  
Diterpene synthases facilitating production of the kaurane skeleton of eriocalyxin B in the medicinal plant Isodon eriocalyx 期刊论文
PHYTOCHEMISTRY, 2019, 卷号: 158, 页码: 96-102
作者:  Du, Gang;  Gong, Hai-Yan;  Feng, Ke-Na;  Chen, Qian-Qian;  Yang, Yan-Long;  Fu, Xiao-Li;  Lu, Shan;  Zeng, Ying
浏览  |  Adobe PDF(1880Kb)  |  收藏  |  浏览/下载:237/49  |  提交时间:2019/03/18
Isodon eriocalyx  Lamiaceae  Biosynthesis  Diterpenoids  Copalyl diphosphate synthase  Kaurene synthase  IeCPS3  IeKS1  
The opioid receptor triple agonist DPI-125 produces analgesia with less respiratory depression and reduced abuse liability 期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 977-989
作者:  Yi, Shou-pu;  Kong, Qing-hong;  Li, Yu-lei;  Pan, Chen-ling;  Yu, Jie;  Cui, Ben-qiang;  Wang, Ying-fei;  Wang, Guan-lin;  Zhou, Pei-lan;  Wang, Li-li;  Gong, Ze-hui;  Su, Rui-bin;  Shen, Yue-hai;  Yu, Gang;  Chang, Kwen-jen
浏览  |  Adobe PDF(854Kb)  |  收藏  |  浏览/下载:359/72  |  提交时间:2017/08/29
Opioid Receptor  Mixed Agonist  Dpi-125  Analgesia  Respiratory Depression  Addiction  
柴胡、石菖蒲和栌菊木的生物活性成分 学位论文
: 中国科学院大学, 2016
作者:  孙长利
Adobe PDF(8402Kb)  |  收藏  |  浏览/下载:148/5  |  提交时间:2018/08/23
Enhanced Diterpene Tanshinone Accumulation and Bioactivity of Transgenic Salvia miltiorrhiza Hairy Roots by Pathway Engineering 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2016, 卷号: 64, 期号: 12, 页码: 2523-2530
作者:  Shi, Min;  Luo, Xiuqin;  Ju, Guanhua;  Li, Leilei;  Huang, Shengxiong;  Zhang, Tong;  Wang, Huizhong;  Kai, Guoyin
浏览  |  Adobe PDF(934Kb)  |  收藏  |  浏览/下载:344/110  |  提交时间:2016/08/22
Hairy Roots  Isoprenoids  Mep Pathway  Salvia Miltiorrhiza  Tanshinbne