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Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 93, 页码: 13
作者:  Zhou, Yeheng;  Sun, Wei;  Peng, Jiale;  Yan, Hui;  Zhang, Li;  Liu, Xingyong;  Zuo, Zhili
浏览  |  Adobe PDF(4739Kb)  |  收藏  |  浏览/下载：206/31  |  提交时间：2020/03/18
Acetylcholinesterase  Drug design  N-acylhydrazone  Dementia  Copper-chelating  N-Benzylpiperidine  
Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives 期刊论文
NATURAL PRODUCT COMMUNICATIONS, 2019, 卷号: 14, 期号: 7, 页码: 6
作者:  Zi, Cheng-Ting;  Yang, Liu;  Zhang, Bang-Lei;  Li, Yan;  Ding, Zhong-Tao;  Jiang, Zi-Hua;  Hu, Jiang-Miao;  Zhou, Jun
浏览  |  Adobe PDF(352Kb)  |  收藏  |  浏览/下载：183/37  |  提交时间：2019/09/10
podophyllotoxin  butyrylated xyloside  cytotoxicity  synthesis  
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 285-294
作者:  Chen, Duo-zhi;  Yang, Bi-juan;  He, Xiao-li;  Fan, Shi-rui;  Cai, Jie-yun;  Jing, Chen-xu;  Zhang, Heng;  Zhang, Yu;  Li, Lin;  Hao, Xiao-jiang
浏览  |  Adobe PDF(3047Kb)  |  收藏  |  浏览/下载：330/41  |  提交时间：2019/03/18
Wnt/beta-catenin signalling pathway agonist  Phenanthridine derivatives  Structural optimization  Structure-activity relationships (SARs)  
Glucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity 期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2019, 卷号: 13, 页码: 3683-3692
作者:  Zi, Cheng-Ting;  Yang, Liu;  Kong, Qing-Hua;  Li, Hong-Mei;  Yang, Xing-Zhi;  Ding, Zhong-Tao;  Jiang, Zi-Hua;  Hu, Jiang-Miao;  Zhou, Jun
浏览  |  Adobe PDF(3776Kb)  |  收藏  |  浏览/下载：174/22  |  提交时间：2020/03/26
podophyllotoxin  glucoside  synthesis  cytotoxicity  physicochemical properties  
Structure-Activity Relationship of Xanthones as Inhibitors of Xanthine Oxidase 期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 2, 页码: 365
作者:  Zhou, Ling-Yun;  Peng, Jia-Le;  Wang, Jun-Ming;  Geng, Yuan-Yuan;  Zuo, Zhi-Li;  Hua, Yan
浏览  |  Adobe PDF(2334Kb)  |  收藏  |  浏览/下载：227/45  |  提交时间：2018/05/08
Xanthone  Xanthine Oxidase Inhibitors  3d-qsar  Gout  
Efficient synthesis of new phenanthridine Wnt/b-catenin signaling pathway agonists 期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: 157, 页码: 1491-1499
作者:  Duozhi Chen;  Heng Zhang;  Chenxu Jing;  Xiaoli He;  Bijuan Yang;  Jieyun Cai;  Yunfu Zhou;  Xiaoming Song;  Lin Li;  Xiaojiang Hao
浏览  |  Adobe PDF(1966Kb)  |  收藏  |  浏览/下载：221/86  |  提交时间：2019/03/27
Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 11, 页码: 4680-4692
作者:  Qu, Chunrong;  Ding, Mingmin;  Zhu, Yingmin;  Lu, Yungang;  Du, Juan;  Miller, Melissa;  Tian, Jinbin;  Zhu, Jinmei;  Xui, Jian;  Wen, Meng;  Er-Bu, Aga;  Wan, Jule;  Xiao, Yuling;  Wu, Meng;  McManus, Owen B.;  Li, Min;  Wu, Jilin;  Luo, Huai-Rong;  Cao, Zhengyu;  Shen, Bing;  Wang, Hongbo;  Zhu, Michael X.;  Hong, Xuechuan
浏览  |  Adobe PDF(1969Kb)  |  收藏  |  浏览/下载：217/77  |  提交时间：2017/08/29
Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2015, 卷号: 172, 期号: 14, 页码: 3495-3509
作者:  Zhu, Yingmin;  Lu, Yungang;  Qu, Chunrong;  Miller, Melissa;  Tian, Jinbin;  Thakur, Dhananjay P.;  Zhu, Jinmei;  Deng, Zixin;  Hu, Xianming;  Wu, Meng;  McManus, Owen B.;  Li, Min;  Hong, Xuechuan;  Zhu, Michael X.;  Luo, Huai-Rong
浏览  |  Adobe PDF(2298Kb)  |  收藏  |  浏览/下载：208/51  |  提交时间：2015/12/15
Synthesis, structure-activity relationships and biological evaluation of caudatin derivatives as novel anti-hepatitis B virus agents 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 卷号: 20, 期号: 9, 页码: 2877-2888
作者:  Wang, Li-Jun;  Geng, Chang-An;  Ma, Yun-Bao;  Huang, Xiao-Yan;  Luo, Jie;  Chen, Hao;  Guo, Rui-Hua;  Zhang, Xue-Mei;  Chen, Ji-Jun
Adobe PDF(2590Kb)  |  收藏  |  浏览/下载：357/125  |  提交时间：2012/06/07
Synthesis  Caudatin Derivatives  Anti-hbv Activity  Structure-activity Relationships  
Molecular docking-based 3D-QSAR studies of pyrrolo[3,4-c]pyrazole derivatives as Aurora-A inhibitors 期刊论文
MOLECULAR SIMULATION, 2011, 卷号: 37, 期号: 1, 页码: 31-42
He, G.; Qiu, M. H.; Li, R.; Song, X. R.; Zheng, X.; Shi, J. Y.; Xu, G. B.; Han, J.; Yu, L. T.; Yang, S. Y.; Chen, L. J.; Wei, Y. Q.
Adobe PDF(551Kb)  |  收藏  |  浏览/下载：354/118  |  提交时间：2012/10/12
Pyrrolo[3  4-c]Pyrazole Derivatives  3d-qsar  Molecular Docking  Comfa  Comsia  Kinase Inhibitors  Protein-kinase  Pharmacophore Model  Similarity Indexes  Analysis Comsia  Potent  Identification  Binding  Profile  Comfa