Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives
Zi, Cheng-Ting1,2; Yang, Liu2; Zhang, Bang-Lei1; Li, Yan2; Ding, Zhong-Tao3; Jiang, Zi-Hua4; Hu, Jiang-Miao2; Zhou, Jun2
通讯作者Jiang, Zi-Hua(zict@ynau.edu.cn) ; Hu, Jiang-Miao(zict@ynau.edu.cn)
2019-07-01
发表期刊NATURAL PRODUCT COMMUNICATIONS
ISSN1934-578X
卷号14期号:7页码:6
摘要Novel podophyllotoxin xyloside derivatives 8 to 11 were synthesized and evaluated for their cytotoxicities against a panel of 5 human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using [3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide] assays. These derivatives showed good to moderate activities, with compound 9 having an IC50 value of 4.42 mu M against the A-549 cell line. Overall, compound 9 might be a promising candidate for further development.
关键词podophyllotoxin butyrylated xyloside cytotoxicity synthesis
DOI10.1177/1934578X19860668
收录类别SCI
语种英语
WOS记录号WOS:000478044500015
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/68142
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Jiang, Zi-Hua; Hu, Jiang-Miao
作者单位1.Yunnan Agr Univ, Coll Sci, Key Lab Pu Er Tea Sci, Minist Educ, Kunming, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming, Yunnan, Peoples R China
4.Lakehead Univ, Dept Chem, 955 Oliver Rd, Thunder Bay, ON P7B 5E1, Canada
推荐引用方式
GB/T 7714
Zi, Cheng-Ting,Yang, Liu,Zhang, Bang-Lei,et al. Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives[J]. NATURAL PRODUCT COMMUNICATIONS,2019,14(7):6.
APA Zi, Cheng-Ting.,Yang, Liu.,Zhang, Bang-Lei.,Li, Yan.,Ding, Zhong-Tao.,...&Zhou, Jun.(2019).Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives.NATURAL PRODUCT COMMUNICATIONS,14(7),6.
MLA Zi, Cheng-Ting,et al."Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives".NATURAL PRODUCT COMMUNICATIONS 14.7(2019):6.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Zi-2019-Synthesis an(352KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zi, Cheng-Ting]的文章
[Yang, Liu]的文章
[Zhang, Bang-Lei]的文章
百度学术
百度学术中相似的文章
[Zi, Cheng-Ting]的文章
[Yang, Liu]的文章
[Zhang, Bang-Lei]的文章
必应学术
必应学术中相似的文章
[Zi, Cheng-Ting]的文章
[Yang, Liu]的文章
[Zhang, Bang-Lei]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Zi-2019-Synthesis and Cytotoxicities of Novel.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。