Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives
Zi, Cheng-Ting1,2; Yang, Liu2; Zhang, Bang-Lei1; Li, Yan2; Ding, Zhong-Tao3; Jiang, Zi-Hua4; Hu, Jiang-Miao2; Zhou, Jun2
Corresponding AuthorJiang, Zi-Hua(zict@ynau.edu.cn) ; Hu, Jiang-Miao(zict@ynau.edu.cn)
2019-07-01
Source PublicationNATURAL PRODUCT COMMUNICATIONS
ISSN1934-578X
Volume14Issue:7Pages:6
AbstractNovel podophyllotoxin xyloside derivatives 8 to 11 were synthesized and evaluated for their cytotoxicities against a panel of 5 human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using [3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide] assays. These derivatives showed good to moderate activities, with compound 9 having an IC50 value of 4.42 mu M against the A-549 cell line. Overall, compound 9 might be a promising candidate for further development.
Keywordpodophyllotoxin butyrylated xyloside cytotoxicity synthesis
DOI10.1177/1934578X19860668
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Food Science & Technology
WOS SubjectChemistry, Medicinal ; Food Science & Technology
WOS IDWOS:000478044500015
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68142
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorJiang, Zi-Hua; Hu, Jiang-Miao
Affiliation1.Yunnan Agr Univ, Coll Sci, Key Lab Pu Er Tea Sci, Minist Educ, Kunming, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming, Yunnan, Peoples R China
4.Lakehead Univ, Dept Chem, 955 Oliver Rd, Thunder Bay, ON P7B 5E1, Canada
Recommended Citation
GB/T 7714
Zi, Cheng-Ting,Yang, Liu,Zhang, Bang-Lei,et al. Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives[J]. NATURAL PRODUCT COMMUNICATIONS,2019,14(7):6.
APA Zi, Cheng-Ting.,Yang, Liu.,Zhang, Bang-Lei.,Li, Yan.,Ding, Zhong-Tao.,...&Zhou, Jun.(2019).Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives.NATURAL PRODUCT COMMUNICATIONS,14(7),6.
MLA Zi, Cheng-Ting,et al."Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives".NATURAL PRODUCT COMMUNICATIONS 14.7(2019):6.
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