| Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives | |
Zi, Cheng-Ting1,2; Yang, Liu2; Zhang, Bang-Lei1; Li, Yan2 ; Ding, Zhong-Tao3; Jiang, Zi-Hua4; Hu, Jiang-Miao2; Zhou, Jun2
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| 通讯作者 | Jiang, Zi-Hua(zict@ynau.edu.cn) ; Hu, Jiang-Miao(zict@ynau.edu.cn) |
| 2019-07-01 | |
| 发表期刊 | NATURAL PRODUCT COMMUNICATIONS
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| ISSN | 1934-578X |
| 卷号 | 14期号:7页码:6 |
| 摘要 | Novel podophyllotoxin xyloside derivatives 8 to 11 were synthesized and evaluated for their cytotoxicities against a panel of 5 human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480) using [3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide] assays. These derivatives showed good to moderate activities, with compound 9 having an IC50 value of 4.42 mu M against the A-549 cell line. Overall, compound 9 might be a promising candidate for further development. |
| 关键词 | podophyllotoxin butyrylated xyloside cytotoxicity synthesis |
| DOI | 10.1177/1934578X19860668 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000478044500015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/68142 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Jiang, Zi-Hua; Hu, Jiang-Miao |
| 作者单位 | 1.Yunnan Agr Univ, Coll Sci, Key Lab Pu Er Tea Sci, Minist Educ, Kunming, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming, Yunnan, Peoples R China 4.Lakehead Univ, Dept Chem, 955 Oliver Rd, Thunder Bay, ON P7B 5E1, Canada |
| 推荐引用方式 GB/T 7714 | Zi, Cheng-Ting,Yang, Liu,Zhang, Bang-Lei,et al. Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives[J]. NATURAL PRODUCT COMMUNICATIONS,2019,14(7):6. |
| APA | Zi, Cheng-Ting.,Yang, Liu.,Zhang, Bang-Lei.,Li, Yan.,Ding, Zhong-Tao.,...&Zhou, Jun.(2019).Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives.NATURAL PRODUCT COMMUNICATIONS,14(7),6. |
| MLA | Zi, Cheng-Ting,et al."Synthesis and Cytotoxicities of Novel Podophyllotoxin Xyloside Derivatives".NATURAL PRODUCT COMMUNICATIONS 14.7(2019):6. |
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| Zi-2019-Synthesis an（352KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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