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Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 104767
作者:  Guo,Sheng;  Xie,Hang;  Lei,Yu;  Liu,Bin;  Zhang,Li;  Xu,Yechun;  Zuo,Zhili
浏览  |  Adobe PDF(3181Kb)  |  收藏  |  浏览/下载：100/30  |  提交时间：2022/04/02
SARS-CoV-2  Main protease  Virtual screening  Biochemical evaluation  
Which species does the virus like most: Binding modes study between SARS-CoV-2 S protein and ACE2 receptor 期刊论文
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2021, 卷号: 105, 页码: 107893
作者:  Guo,Sheng;  Yang,Jing;  Lei,Yu;  Liu,Bin;  Zhang,Wei;  Zhang,Li;  Zuo,Zhili
浏览  |  Adobe PDF(3681Kb)  |  收藏  |  浏览/下载：90/12  |  提交时间：2022/04/02
SARS-CoV-2  COVID-19  Homology modeling  Molecular dynamics simulation  Binding free energy  CORONAVIRUS SPIKE PROTEIN  ACTIVATION  GROMACS  ENTRY  
The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020
作者:  Xu, Guowei;  Yang, Yaqing;  Yang, Yanming;  Song, Gao;  Li, Shanshan;  Zhang, Jiajun;  Yang, Weimin;  Wang, Liang-Liang;  Weng, Zhiying;  Zuo, Zhili
浏览  |  Adobe PDF(2526Kb)  |  收藏  |  浏览/下载：126/29  |  提交时间：2021/01/05
Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 93, 页码: 13
作者:  Zhou, Yeheng;  Sun, Wei;  Peng, Jiale;  Yan, Hui;  Zhang, Li;  Liu, Xingyong;  Zuo, Zhili
浏览  |  Adobe PDF(4739Kb)  |  收藏  |  浏览/下载：206/31  |  提交时间：2020/03/18
Acetylcholinesterase  Drug design  N-acylhydrazone  Dementia  Copper-chelating  N-Benzylpiperidine  
Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 21, 页码: 9053-9066
作者:  Shao, Li-Dong;  Su, Jia;  Ye, Baixin;  Liu, Jiang-Xin;  Zuo, Zhi-Li;  Li, Yan;  Wang, Yue-Ying;  Xia, Chengfeng;  Zhao, Qin-Shi
浏览  |  Adobe PDF(5724Kb)  |  收藏  |  浏览/下载：390/43  |  提交时间：2017/12/18
Design and prediction of new acetylcholinesterase inhibitor via quantitative structure activity relationship of huprines derivatives 期刊论文
ARCHIVES OF PHARMACAL RESEARCH, 2016, 卷号: 39, 期号: 5, 页码: 591-602
作者:  Zhang, Shuqun;  Hou, Bo;  Yang, Huaiyu;  Zuo, Zhili
浏览  |  Adobe PDF(1125Kb)  |  收藏  |  浏览/下载：255/84  |  提交时间：2016/08/22
Ache  Ad  Hqsar  Comfa  Comsia  Huprines Inhibitors  
The discovery of new acetylcholinesterase inhibitors derived from pharmacophore modeling, virtual screening, docking simulation and bioassays 期刊论文
MOLECULAR BIOSYSTEMS, 2016, 卷号: 12, 期号: 12, 页码: 3734-3742
作者:  Zhang, Yunqin;  Zhang, Shuqun;  Xu, Guowei;  Yan, Hui;  Pua, Yinglan;  Zuo, Zhili
浏览  |  Adobe PDF(1699Kb)  |  收藏  |  浏览/下载：175/52  |  提交时间：2017/02/14
Lingzhilactones from Ganoderma lingzhi ameliorate adriamycin-induced nephropathy in mice 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2015, 卷号: 176, 页码: 385-393
作者:  Yan, Yong-Ming;  Wang, Xin-Long;  Zhou, Li-Li;  Zhou, Feng-Jiao;  Li, Rong;  Tian, Yuan;  Zuo, Zhi-Li;  Fang, Ping;  Chung, Arthur C. K.;  Hou, Fan-Fan;  Cheng, Yong-Xian
浏览  |  Adobe PDF(8566Kb)  |  收藏  |  浏览/下载：652/72  |  提交时间：2016/02/01
Ganoderma Lingzhi  Ganodermataceae  Meroterpenoids  Chronic Kidney Disease  Reactive Oxygen Species  Nrf2  
Bioactive compounds from the insect Aspongopus chinensis 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 22, 页码: 5164-5169
作者:  Shi, Yan-Ni;  Tu, Zheng-Chao;  Wang, Xin-Long;  Yan, Yong-Ming;  Fang, Ping;  Zuo, Zhi-Li;  Hou, Bo;  Yang, Tong-Hua;  Cheng, Yong-Xian;  Yang,TH (reprint author),First Peoples Hosp Yunnan Prov,Dept Hematol,Kunming 650032,Peoples R China.;  ynanblood@aliyun.com;  yxcheng@mail.kib.ac.cn
浏览  |  Adobe PDF(695Kb)  |  收藏  |  浏览/下载：312/95  |  提交时间：2015/01/20
Aspongopus Chinensis  Insects  Norepinephrine Derivatives  Sesquiterpenoids  Lactam  Biological Evaluation  
(+/-)-Aspongamide A, an N-Acetyldopamine Trimer Isolated from the Insect Aspongopus chinensis, Is an Inhibitor of p-Smad3 期刊论文
ORGANIC LETTERS, 2014, 卷号: 16, 期号: 2, 页码: 532-535
作者:  Yan, Yong-Ming;  Ai, Jun;  Shi, Yan-Ni;  Zuo, Zhi-Li;  Hou, Bo;  Luo, Jie;  Cheng, Yong-Xian
Adobe PDF(229Kb)  |  收藏  |  浏览/下载：456/79  |  提交时间：2014/04/09
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