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Discovery of new dual binding TNKS inhibitors of Wnt signaling inhibition by pharmacophore modeling, molecular docking and bioassay 期刊论文
MOLECULAR BIOSYSTEMS, 2017, 卷号: 13, 期号: 2, 页码: 363-370
作者:  Pu, Yinglan;  Zhang, Shuqun;  Chang, Zhe;  Zhang, Yunqin;  Wang, Dong;  Zhang, Li;  Li, Yan;  Zuo, Zhili
浏览  |  Adobe PDF(972Kb)  |  收藏  |  浏览/下载：696/120  |  提交时间：2017/05/19
Enantioselective total synthesis of (+)-Lingzhiol via tandem semipinacol rearrangement/Friedel- Crafts type cyclization 期刊论文
CHEMICAL COMMUNICATIONS, 2016, 卷号: 52, 期号: 55, 页码: 8561-8564
作者:  Chen, Dong;  Xu, Wen-Dan;  Liu, Hao-Miao;  Li, Ming-Ming;  Yan, Yong-Min;  Li, Xiao-Nian;  Li, Yan;  Cheng, Yong-Xian;  Qin, Hong-Bo
浏览  |  Adobe PDF(531Kb)  |  收藏  |  浏览/下载：249/58  |  提交时间：2016/09/28
Laxiflorol A, the first example of 7,8:15,16-di-seco-15-nor-21-homo-ent-kauranoid from Isodon eriocalyx var. laxiflora 期刊论文
RSC ADVANCES, 2015, 卷号: 5, 期号: 8, 页码: 6132-6135
作者:  Wang,Wei-Guang;  Tang,Jian-Wei;  Shi,Yi-Ming;  Du,Xue;  Li,Xiao-Nian;  Wu,Hai-Yan;  Jiang,Hua-Yi;  Li,Yan;  Pu,Jian-Xin;  Sun,Han-Dong;  Pu,JX (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China.
浏览  |  Adobe PDF(1172Kb)  |  收藏  |  浏览/下载：188/26  |  提交时间：2015/06/29
Xylariterpenoids A-D, four new sesquiterpenoids from the Xylariaceae fungus 期刊论文
RSC ADVANCES, 2014, 卷号: 4, 期号: 97, 页码: 54144-54148
作者:  Wu, Zu-Yan;  Wu, Yang;  Chen, Guo-Dong;  Hu, Dan;  Li, Xiao-Xia;  Sun, Xiang;  Guo, Liang-Dong;  Li, Yan;  Yao, Xin-Sheng;  Gao, Hao;  Gao,H (reprint author),Jinan Univ,Coll Pharm,Inst Tradit Chinese Med & Nat Prod,Guangzhou 510632,Guangdong,Peoples R China.
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Fruiting Bodies  Flavonoids  Extracts  Lucidum  Triterpenoids  Fornicatum  Sinense  Rats  Body  Ganoderma Cochlear  Prenylated Phenols  Antioxidant Activity  X-ray Crystallography Analysis  Chiral Hplc Chromatography  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：271/44  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.