Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces
Wang Lei1,2,3; Wang Li1,2,5; Zhou Zhi1,2,4,5; Wang Yong-Jiang1,2,5; Huang Jian-Ping1,2; Ma Ya-Tuan3; Liu Yang4; Huang Sheng-Xiong1,2
Corresponding AuthorHuang Sheng-Xiong(sxhuang@mail.kib.ac.cn)
2019-12-01
Source PublicationCHINESE JOURNAL OF NATURAL MEDICINES
ISSN2095-6975
Volume17Issue:12Pages:982-987
AbstractCangumycins A-F (1-6), six new angucyclinone analogues, together with two known ones (7 and 8), were isolated from the fermentation broth of a soil-derived Streptomyces sp. KIB-M10. Structures of these compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Among them, cangumycins E (5) and F (6) share a C-ring cleaved backbone, and cangumycins B (2) and E (5) exhibit potent immunosuppressive activity (IC50 8.1 and 2.7 mu mol.L-1, respectively) against human T cell proliferation at a non-cytotoxic concentration.
KeywordStreptomyces Angucyclinones Benz[a]anthracenes Natural products Immunosuppressive activity
Indexed BySCI ; SCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS SubjectIntegrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS IDWOS:000504330400016
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/70557
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorHuang Sheng-Xiong
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, CAS Ctr Excellence Mol Plant Sci, Kunming 650201, Yunnan, Peoples R China
3.Northwest Agr & Forestry Univ, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China
4.Chengdu Med Coll, Res Ctr, Chengdu 610500, Sichuan, Peoples R China
5.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wang Lei,Wang Li,Zhou Zhi,et al. Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(12):982-987.
APA Wang Lei.,Wang Li.,Zhou Zhi.,Wang Yong-Jiang.,Huang Jian-Ping.,...&Huang Sheng-Xiong.(2019).Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces.CHINESE JOURNAL OF NATURAL MEDICINES,17(12),982-987.
MLA Wang Lei,et al."Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces".CHINESE JOURNAL OF NATURAL MEDICINES 17.12(2019):982-987.
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