| Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces | |
Wang Lei1,2,3 ; Wang Li1,2,5; Zhou Zhi1,2,4,5; Wang Yong-Jiang1,2,5; Huang Jian-Ping1,2; Ma Ya-Tuan3; Liu Yang4; Huang Sheng-Xiong1,2
| |
| Corresponding Author | Huang Sheng-Xiong(sxhuang@mail.kib.ac.cn) |
| 2019-12-01 | |
| Source Publication | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| ISSN | 2095-6975 |
| Volume | 17Issue:12Pages:982-987 |
| Abstract | Cangumycins A-F (1-6), six new angucyclinone analogues, together with two known ones (7 and 8), were isolated from the fermentation broth of a soil-derived Streptomyces sp. KIB-M10. Structures of these compounds were elucidated via a joint use of spectroscopic analyses and single-crystal X-ray diffractions. Among them, cangumycins E (5) and F (6) share a C-ring cleaved backbone, and cangumycins B (2) and E (5) exhibit potent immunosuppressive activity (IC50 8.1 and 2.7 mu mol.L-1, respectively) against human T cell proliferation at a non-cytotoxic concentration. |
| Keyword | Streptomyces Angucyclinones Benz[a]anthracenes Natural products Immunosuppressive activity |
| Indexed By | SCI ; SCI |
| Language | 英语 |
| WOS ID | WOS:000504330400016 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/70557 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Huang Sheng-Xiong |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, CAS Ctr Excellence Mol Plant Sci, Kunming 650201, Yunnan, Peoples R China 3.Northwest Agr & Forestry Univ, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China 4.Chengdu Med Coll, Res Ctr, Chengdu 610500, Sichuan, Peoples R China 5.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Wang Lei,Wang Li,Zhou Zhi,et al. Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(12):982-987. |
| APA | Wang Lei.,Wang Li.,Zhou Zhi.,Wang Yong-Jiang.,Huang Jian-Ping.,...&Huang Sheng-Xiong.(2019).Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces.CHINESE JOURNAL OF NATURAL MEDICINES,17(12),982-987. |
| MLA | Wang Lei,et al."Cangumycins A-F, six new angucyclinone analogues with immunosuppressive activity from Streptomyces".CHINESE JOURNAL OF NATURAL MEDICINES 17.12(2019):982-987. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| Wang-2019-Cangumycin（563KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment