Alkaloids isolated from Tabemaemontana bufalina display xanthine oxidase inhibitory activity

doi:10.1016/j.phytochem.2019.112060

	Alkaloids isolated from Tabemaemontana bufalina display xanthine oxidase inhibitory activity
	Shi, Bao-Bao 1,2; Chen, Jing 1,2; Bao, Mei-Fen 1,2; Zeng, Ying1,3 ; Cai, Xiang-Hai1,3
通讯作者	Zeng, Ying(biochem@mail.kib.ac.cn) ; Cai, Xiang-Hai(xhcai@mail.kib.ac.cn)
	2019-10-01
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	166 页码:8
摘要	Continued interest in bioactive alkaloids led to the isolation of four undescribed alkaloids along with 74 known ones from the aerial parts of Tabernaemontana bufalina Lour. The structures of the yet undescribed alkaloids were elucidated based on NMR, IR, UV, MS and CD spectroscopic data and X-ray crystal diffraction and, according to the plant source, named as taberhaines A-D (1-4). The known compounds comprised of 66 monoterpenoid indole, three carboline and five isoquinoline alkaloids. Among them, the known apparicine inhibited significantly the activity of xanthine oxidase, which plays an important role for gout, with an IC50 value of 0.65 mu M, compared to the standard drug allopurinol (IC50 = 0.60 mu M).
关键词	Tabernaemontana bufalina apocynaceae Alkaloid Taberhaines A-D Apparicine Xanthine oxidase inhibitor
DOI	10.1016/j.phytochem.2019.112060
收录类别	SCI
语种	英语
WOS记录号	WOS:000484650500010
引用统计	被引频次：32[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/68693
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zeng, Ying; Cai, Xiang-Hai
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Shi, Bao-Bao,Chen, Jing,Bao, Mei-Fen,et al. Alkaloids isolated from Tabemaemontana bufalina display xanthine oxidase inhibitory activity[J]. PHYTOCHEMISTRY,2019,166:8.
APA	Shi, Bao-Bao,Chen, Jing,Bao, Mei-Fen,Zeng, Ying,&Cai, Xiang-Hai.(2019).Alkaloids isolated from Tabemaemontana bufalina display xanthine oxidase inhibitory activity.PHYTOCHEMISTRY,166,8.
MLA	Shi, Bao-Bao,et al."Alkaloids isolated from Tabemaemontana bufalina display xanthine oxidase inhibitory activity".PHYTOCHEMISTRY 166(2019):8.

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