Alkaloids isolated from Tabemaemontana bufalina display xanthine oxidase inhibitory activity
Shi, Bao-Bao1,2; Chen, Jing1,2; Bao, Mei-Fen1,2; Zeng, Ying1,3; Cai, Xiang-Hai1,3
Corresponding AuthorZeng, Ying(biochem@mail.kib.ac.cn) ; Cai, Xiang-Hai(xhcai@mail.kib.ac.cn)
2019-10-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume166Pages:8
AbstractContinued interest in bioactive alkaloids led to the isolation of four undescribed alkaloids along with 74 known ones from the aerial parts of Tabernaemontana bufalina Lour. The structures of the yet undescribed alkaloids were elucidated based on NMR, IR, UV, MS and CD spectroscopic data and X-ray crystal diffraction and, according to the plant source, named as taberhaines A-D (1-4). The known compounds comprised of 66 monoterpenoid indole, three carboline and five isoquinoline alkaloids. Among them, the known apparicine inhibited significantly the activity of xanthine oxidase, which plays an important role for gout, with an IC50 value of 0.65 mu M, compared to the standard drug allopurinol (IC50 = 0.60 mu M).
KeywordTabernaemontana bufalina apocynaceae Alkaloid Taberhaines A-D Apparicine Xanthine oxidase inhibitor
DOI10.1016/j.phytochem.2019.112060
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000484650500010
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68693
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorZeng, Ying; Cai, Xiang-Hai
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Shi, Bao-Bao,Chen, Jing,Bao, Mei-Fen,et al. Alkaloids isolated from Tabemaemontana bufalina display xanthine oxidase inhibitory activity[J]. PHYTOCHEMISTRY,2019,166:8.
APA Shi, Bao-Bao,Chen, Jing,Bao, Mei-Fen,Zeng, Ying,&Cai, Xiang-Hai.(2019).Alkaloids isolated from Tabemaemontana bufalina display xanthine oxidase inhibitory activity.PHYTOCHEMISTRY,166,8.
MLA Shi, Bao-Bao,et al."Alkaloids isolated from Tabemaemontana bufalina display xanthine oxidase inhibitory activity".PHYTOCHEMISTRY 166(2019):8.
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