| Alkaloids isolated from Tabemaemontana bufalina display xanthine oxidase inhibitory activity | |
Shi, Bao-Bao1,2; Chen, Jing1,2; Bao, Mei-Fen1,2; Zeng, Ying1,3 ; Cai, Xiang-Hai1,3
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| Corresponding Author | Zeng, Ying(biochem@mail.kib.ac.cn) ; Cai, Xiang-Hai(xhcai@mail.kib.ac.cn) |
| 2019-10-01 | |
| Source Publication | PHYTOCHEMISTRY
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| ISSN | 0031-9422 |
| Volume | 166Pages:8 |
| Abstract | Continued interest in bioactive alkaloids led to the isolation of four undescribed alkaloids along with 74 known ones from the aerial parts of Tabernaemontana bufalina Lour. The structures of the yet undescribed alkaloids were elucidated based on NMR, IR, UV, MS and CD spectroscopic data and X-ray crystal diffraction and, according to the plant source, named as taberhaines A-D (1-4). The known compounds comprised of 66 monoterpenoid indole, three carboline and five isoquinoline alkaloids. Among them, the known apparicine inhibited significantly the activity of xanthine oxidase, which plays an important role for gout, with an IC50 value of 0.65 mu M, compared to the standard drug allopurinol (IC50 = 0.60 mu M). |
| Keyword | Tabernaemontana bufalina apocynaceae Alkaloid Taberhaines A-D Apparicine Xanthine oxidase inhibitor |
| DOI | 10.1016/j.phytochem.2019.112060 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000484650500010 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/68693 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Zeng, Ying; Cai, Xiang-Hai |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China |
| Recommended Citation GB/T 7714 | Shi, Bao-Bao,Chen, Jing,Bao, Mei-Fen,et al. Alkaloids isolated from Tabemaemontana bufalina display xanthine oxidase inhibitory activity[J]. PHYTOCHEMISTRY,2019,166:8. |
| APA | Shi, Bao-Bao,Chen, Jing,Bao, Mei-Fen,Zeng, Ying,&Cai, Xiang-Hai.(2019).Alkaloids isolated from Tabemaemontana bufalina display xanthine oxidase inhibitory activity.PHYTOCHEMISTRY,166,8. |
| MLA | Shi, Bao-Bao,et al."Alkaloids isolated from Tabemaemontana bufalina display xanthine oxidase inhibitory activity".PHYTOCHEMISTRY 166(2019):8. |
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| Shi-2019-Alkaloids i（956KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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