Neo-clerodane diterpenoids from aerial parts of Salvia hispanica L. and their cardioprotective effects
Fan, Min1,2; Luo, Dan1; Peng, Li-Yan1; Li, Xiao-Nian1; Wu, Xing-De1; Ji, Xu1; Zhao, Qin-Shi1
Corresponding AuthorWu, Xing-De(wuxingde@mail.kib.ac.cn) ; Ji, Xu(jixu@mail.kib.ac.cn) ; Zhao, Qin-Shi(qinshizhao@mail.kib.ac.cn)
2019-10-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume166Pages:11
AbstractTen undescribed neo-clerodane diterpenoids, named hispanins A-J, together with six known ones, were isolated from the aerial parts of Salvia hispanica L. Their structures were established by extensive spectroscopic analysis. The absolute configurations of the undescribed compounds were determined by the ECD data and single crystal X-ray diffraction analysis. Hispanins B and C represented the first neo-clerodane diterpenoids with a unique oxygen bridge between C-19 and C-20. All isolated compounds were evaluated for their protective effects against H2O2-induced cardiomyocyte injury. Five of these compounds showed significant cardioprotective effects.
KeywordSalvia hispanica L. (Lamiaceae) Chia Neo-clerodane diterpenoids Hispanins A-J Single crystal X-ray diffraction analysis Cardioprotective effects
DOI10.1016/j.phytochem.2019.112065
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000484650500014
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/68630
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorWu, Xing-De; Ji, Xu; Zhao, Qin-Shi
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
2.Dali Univ, Coll Pharmaceut Sci, Dali 671000, Peoples R China
Recommended Citation
GB/T 7714
Fan, Min,Luo, Dan,Peng, Li-Yan,et al. Neo-clerodane diterpenoids from aerial parts of Salvia hispanica L. and their cardioprotective effects[J]. PHYTOCHEMISTRY,2019,166:11.
APA Fan, Min.,Luo, Dan.,Peng, Li-Yan.,Li, Xiao-Nian.,Wu, Xing-De.,...&Zhao, Qin-Shi.(2019).Neo-clerodane diterpenoids from aerial parts of Salvia hispanica L. and their cardioprotective effects.PHYTOCHEMISTRY,166,11.
MLA Fan, Min,et al."Neo-clerodane diterpenoids from aerial parts of Salvia hispanica L. and their cardioprotective effects".PHYTOCHEMISTRY 166(2019):11.
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