| Neo-clerodane diterpenoids from aerial parts of Salvia hispanica L. and their cardioprotective effects | |
Fan, Min1,2 ; Luo, Dan1; Peng, Li-Yan1; Li, Xiao-Nian1; Wu, Xing-De1; Ji, Xu1; Zhao, Qin-Shi1
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| Corresponding Author | Wu, Xing-De(wuxingde@mail.kib.ac.cn) ; Ji, Xu(jixu@mail.kib.ac.cn) ; Zhao, Qin-Shi(qinshizhao@mail.kib.ac.cn) |
| 2019-10-01 | |
| Source Publication | PHYTOCHEMISTRY
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| ISSN | 0031-9422 |
| Volume | 166Pages:11 |
| Abstract | Ten undescribed neo-clerodane diterpenoids, named hispanins A-J, together with six known ones, were isolated from the aerial parts of Salvia hispanica L. Their structures were established by extensive spectroscopic analysis. The absolute configurations of the undescribed compounds were determined by the ECD data and single crystal X-ray diffraction analysis. Hispanins B and C represented the first neo-clerodane diterpenoids with a unique oxygen bridge between C-19 and C-20. All isolated compounds were evaluated for their protective effects against H2O2-induced cardiomyocyte injury. Five of these compounds showed significant cardioprotective effects. |
| Keyword | Salvia hispanica L. (Lamiaceae) Chia Neo-clerodane diterpenoids Hispanins A-J Single crystal X-ray diffraction analysis Cardioprotective effects |
| DOI | 10.1016/j.phytochem.2019.112065 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000484650500014 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/68630 |
| Collection | 植物化学与西部植物资源持续利用国家重点实验室 |
| Corresponding Author | Wu, Xing-De; Ji, Xu; Zhao, Qin-Shi |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 2.Dali Univ, Coll Pharmaceut Sci, Dali 671000, Peoples R China |
| Recommended Citation GB/T 7714 | Fan, Min,Luo, Dan,Peng, Li-Yan,et al. Neo-clerodane diterpenoids from aerial parts of Salvia hispanica L. and their cardioprotective effects[J]. PHYTOCHEMISTRY,2019,166:11. |
| APA | Fan, Min.,Luo, Dan.,Peng, Li-Yan.,Li, Xiao-Nian.,Wu, Xing-De.,...&Zhao, Qin-Shi.(2019).Neo-clerodane diterpenoids from aerial parts of Salvia hispanica L. and their cardioprotective effects.PHYTOCHEMISTRY,166,11. |
| MLA | Fan, Min,et al."Neo-clerodane diterpenoids from aerial parts of Salvia hispanica L. and their cardioprotective effects".PHYTOCHEMISTRY 166(2019):11. |
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| Fan-2019-Neo-cleroda（1457KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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