Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate
Qin, Xu-Jie1; Rauwolf, Tyler J.2; Li, Pan-Pan3; Liu, Hui1; McNeely, James2; Hua, Yan3; Liu, Hai-Yang1; Porco, John A., Jr.2
通讯作者Liu, Hai-Yang(haiyangliu@mail.kib.ac.cn) ; Porco, John A., Jr.(porco@bu.edu)
2019-03-22
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
卷号58期号:13页码:4291-4296
摘要RhodomyrtusialsA-C, the first examples of triketone-sesquiterpene meroterpenoids featuring a unique 6/5/5/9/4 fused pentacyclic ring system were isolated from Rhodomyrtus tomentosa, along with several biogenetically-related dihydropyran isomers. Two bis-furans and one dihydropyran isomer showed acetylcholinesterase (AChE) inhibitory activity. Structures of the isolates were unambiguously established by a combination of spectroscopic data, ECD analysis, and total synthesis. Bioinspired total syntheses of six isolates were achieved in six steps utilizing a reactive enetrione intermediate generated in situ from a readily available hydroxy-endoperoxide precursor.
关键词biomimetic synthesis Diels-Alder enetrione terpenoids total synthesis
DOI10.1002/anie.201814421
收录类别SCI
语种英语
WOS记录号WOS:000462655400032
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/67656
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Liu, Hai-Yang; Porco, John A., Jr.
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Boston Univ, Ctr Mol Discovery BUCMD, Dept Chem, 590 Commonwealth Ave, Boston, MA 02215 USA
3.Southwest Forestry Univ, Coll Forestry, Kunming 650224, Yunnan, Peoples R China
推荐引用方式
GB/T 7714
Qin, Xu-Jie,Rauwolf, Tyler J.,Li, Pan-Pan,et al. Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(13):4291-4296.
APA Qin, Xu-Jie.,Rauwolf, Tyler J..,Li, Pan-Pan.,Liu, Hui.,McNeely, James.,...&Porco, John A., Jr..(2019).Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(13),4291-4296.
MLA Qin, Xu-Jie,et al."Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.13(2019):4291-4296.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Qin-2019-Isolation a(1347KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Qin, Xu-Jie]的文章
[Rauwolf, Tyler J.]的文章
[Li, Pan-Pan]的文章
百度学术
百度学术中相似的文章
[Qin, Xu-Jie]的文章
[Rauwolf, Tyler J.]的文章
[Li, Pan-Pan]的文章
必应学术
必应学术中相似的文章
[Qin, Xu-Jie]的文章
[Rauwolf, Tyler J.]的文章
[Li, Pan-Pan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Qin-2019-Isolation and Synthesis of Novel Mero.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。