Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits
Qin, Xu-Jie1; Jin, Ling-Yu1,2; Yu, Qian3; Liu, Hui1; Khan, Afsar4; Yan, Huan1; Hao, Xiao-Jiang1; An, Lin-Kun3; Liu, Hai-Yang1
2018-12-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume81Issue:12Pages:2638-2646
AbstractTen new formyl-phloroglucinol terpene meroterpenoids, eucalypglobulusals A-J (1-10), and ten known analogues were isolated from Eucalyptus globulus fruits. The structures of 1-10 were determined by spectroscopic analysis, while their absolute configurations were established using calculated and experimental electronic circular dichroism (ECD) spectra. Eucalypglobulusal A was assigned as a new formyl-phloroglucinol- terpene meroterpenoid with a rearranged sesquiterpene skeleton, and an aldol condensation between C-3 and C-5 of the germacrene C moiety was proposed to be a key step in its putative biosynthetic pathway. Eucalypglobulusal F exhibited cytotoxicity against the human acute lymphoblastic cell line (CCRF-CEM) with an IC50 value of 3.3 mu M, while eucalypglobulusal A, eucarobustol C, macrocarpal A, macrocarpal B, and macrocarpal D exhibited DNA topoisomerase I (Top1) inhibition. The compounds eucalypglobulusal A and macrocarpal A act as Top1 catalytic inhibitors and delay Topl poison-mediated DNA double-strand damage.
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64319
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorAn, Lin-Kun; Liu, Hai-Yang
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.West Yunnan Univ Appl Sci, Sch Tradit Dai Thai Med, Jinghong 666100, Peoples R China
3.Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Med Chem & Chem Biol, Guangzhou 510006, Guangdong, Peoples R China
4.COMSATS Univ Islamabad, Dept Chem, Abbottabad Campus, Abbottabad 22060, Pakistan
Recommended Citation
GB/T 7714
Qin, Xu-Jie,Jin, Ling-Yu,Yu, Qian,et al. Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(12):2638-2646.
APA Qin, Xu-Jie.,Jin, Ling-Yu.,Yu, Qian.,Liu, Hui.,Khan, Afsar.,...&Liu, Hai-Yang.(2018).Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits.JOURNAL OF NATURAL PRODUCTS,81(12),2638-2646.
MLA Qin, Xu-Jie,et al."Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits".JOURNAL OF NATURAL PRODUCTS 81.12(2018):2638-2646.
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