Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits

	Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits
	Qin, Xu-Jie1 ; Jin, Ling-Yu 1,2; Yu, Qian 3; Liu, Hui 1; Khan, Afsar 4; Yan, Huan 1; Hao, Xiao-Jiang1 ; An, Lin-Kun 3; Liu, Hai-Yang1
	2018-12-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	81 期号:12 页码:2638-2646
摘要	Ten new formyl-phloroglucinol terpene meroterpenoids, eucalypglobulusals A-J (1-10), and ten known analogues were isolated from Eucalyptus globulus fruits. The structures of 1-10 were determined by spectroscopic analysis, while their absolute configurations were established using calculated and experimental electronic circular dichroism (ECD) spectra. Eucalypglobulusal A was assigned as a new formyl-phloroglucinol- terpene meroterpenoid with a rearranged sesquiterpene skeleton, and an aldol condensation between C-3 and C-5 of the germacrene C moiety was proposed to be a key step in its putative biosynthetic pathway. Eucalypglobulusal F exhibited cytotoxicity against the human acute lymphoblastic cell line (CCRF-CEM) with an IC50 value of 3.3 mu M, while eucalypglobulusal A, eucarobustol C, macrocarpal A, macrocarpal B, and macrocarpal D exhibited DNA topoisomerase I (Top1) inhibition. The compounds eucalypglobulusal A and macrocarpal A act as Top1 catalytic inhibitors and delay Topl poison-mediated DNA double-strand damage.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64319
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	An, Lin-Kun; Liu, Hai-Yang
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.West Yunnan Univ Appl Sci, Sch Tradit Dai Thai Med, Jinghong 666100, Peoples R China 3.Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Med Chem & Chem Biol, Guangzhou 510006, Guangdong, Peoples R China 4.COMSATS Univ Islamabad, Dept Chem, Abbottabad Campus, Abbottabad 22060, Pakistan
推荐引用方式 GB/T 7714	Qin, Xu-Jie,Jin, Ling-Yu,Yu, Qian,et al. Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(12):2638-2646.
APA	Qin, Xu-Jie.,Jin, Ling-Yu.,Yu, Qian.,Liu, Hui.,Khan, Afsar.,...&Liu, Hai-Yang.(2018).Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits.JOURNAL OF NATURAL PRODUCTS,81(12),2638-2646.
MLA	Qin, Xu-Jie,et al."Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits".JOURNAL OF NATURAL PRODUCTS 81.12(2018):2638-2646.