Synthesis of Novel ent-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells

	Synthesis of Novel ent-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells
	Hu, Yu 1; Li, Xiao-Nian 2; Ma, Ze-Jin 1; Puno, Pema-Tenzin2 ; Zhao, Yong 1; Zhao, Yan 1; Xiao, Ye-Zhi 1; Zhang, Wei 1; Liu, Jing-Ping 1
	2018-12-01
发表期刊	MOLECULES
ISSN	1420-3049
卷号	23 期号:12 页码:9
摘要	We have designed and synthesized 6 ent-Kaurane-type diterpenoid derivatives containing ,-unsaturated ketone moieties. In vitro, activity was evaluated against three human tumor cell lines and a rat myogenic cell line (HepG2, NSCLC-H292, SNU-1040, L6) by MTT assay. All the tested compounds exhibited comparable or higher activity than DDP and eriocalyxin B. Compounds 16, 17 and 18 are promising anti-tumor leads due to their cytotoxic potencies and higher selectivity, with SI values of 161.06, 47.80 and 128.20, respectively.
关键词	ent-kaurane-type diterpenoid derivatives antitumor synthesis
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64301
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Puno, Pema-Tenzin; Liu, Jing-Ping
作者单位	1.Yunnan Normal Univ, Dept Chem, Kunming 650092, Yunnan, Peoples R China 2.Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West C, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Hu, Yu,Li, Xiao-Nian,Ma, Ze-Jin,et al. Synthesis of Novel ent-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells[J]. MOLECULES,2018,23(12):9.
APA	Hu, Yu.,Li, Xiao-Nian.,Ma, Ze-Jin.,Puno, Pema-Tenzin.,Zhao, Yong.,...&Liu, Jing-Ping.(2018).Synthesis of Novel ent-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells.MOLECULES,23(12),9.
MLA	Hu, Yu,et al."Synthesis of Novel ent-Kaurane-Type Diterpenoid Derivatives Effective for Highly Aggressive Tumor Cells".MOLECULES 23.12(2018):9.