miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells

	miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells
	Liang, Huichun 1,2; Ge, Fei 3; Xu, Yuhui 2; Xiao, Ji 1; Zhou, Zhongmei 1; Liu, Rong 1; Chen, Ceshi 1
	2018-11-01
发表期刊	ANGIOGENESIS
ISSN	0969-6970
卷号	21 期号:4 页码:849-860
摘要	The sprouting of endothelial cells is the first step of tumor angiogenesis. Our previous study suggests that miR-153 suppresses breast tumor angiogenesis partially through targeting hypoxia-induced factor (HIF1). In this study, we demonstrated that miR-153 also suppresses the migration and the tube formation of endothelial cells through directly targeting angiopoietin 1 (ANG1) in breast cancer cells. There was a negative correlation between miR-153 and ANG1 levels in breast cancer. miR-153 blocked the expression and secretion of ANG1 in breast cancer cells through binding to ANG1 mRNA. Conditioned medium from the breast cancer cell, MCF7, treated with miR-153 had no effect on the proliferation of HUVECs, but significantly inhibited the migration and tube formation of HUVECs, which could be rescued by overexpression of ANG1. In addition, miR-153 also directly inhibited the proliferation and migration of MCF7 through downregulation of ANG1. These findings suggest that miR-153 suppresses the activity of tumor cells and the migration and tube formation of endothelial cells by silencing ANG1.
关键词	MiR-153 Angiopoietin 1 Endothelial cell Tumor angiogenesis Breast cancer
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/63091
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Liang, Huichun; Chen, Ceshi
作者单位	1.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Kunming Med Univ, Dept Breast Surg, Affiliated Hosp 1, Kunming 650032, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Liang, Huichun,Ge, Fei,Xu, Yuhui,et al. miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells[J]. ANGIOGENESIS,2018,21(4):849-860.
APA	Liang, Huichun.,Ge, Fei.,Xu, Yuhui.,Xiao, Ji.,Zhou, Zhongmei.,...&Chen, Ceshi.(2018).miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells.ANGIOGENESIS,21(4),849-860.
MLA	Liang, Huichun,et al."miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells".ANGIOGENESIS 21.4(2018):849-860.