miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells
Liang, Huichun1,2; Ge, Fei3; Xu, Yuhui2; Xiao, Ji1; Zhou, Zhongmei1; Liu, Rong1; Chen, Ceshi1
2018-11-01
Source PublicationANGIOGENESIS
ISSN0969-6970
Volume21Issue:4Pages:849-860
AbstractThe sprouting of endothelial cells is the first step of tumor angiogenesis. Our previous study suggests that miR-153 suppresses breast tumor angiogenesis partially through targeting hypoxia-induced factor (HIF1). In this study, we demonstrated that miR-153 also suppresses the migration and the tube formation of endothelial cells through directly targeting angiopoietin 1 (ANG1) in breast cancer cells. There was a negative correlation between miR-153 and ANG1 levels in breast cancer. miR-153 blocked the expression and secretion of ANG1 in breast cancer cells through binding to ANG1 mRNA. Conditioned medium from the breast cancer cell, MCF7, treated with miR-153 had no effect on the proliferation of HUVECs, but significantly inhibited the migration and tube formation of HUVECs, which could be rescued by overexpression of ANG1. In addition, miR-153 also directly inhibited the proliferation and migration of MCF7 through downregulation of ANG1. These findings suggest that miR-153 suppresses the activity of tumor cells and the migration and tube formation of endothelial cells by silencing ANG1.
KeywordMiR-153 Angiopoietin 1 Endothelial cell Tumor angiogenesis Breast cancer
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/63091
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLiang, Huichun; Chen, Ceshi
Affiliation1.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Kunming Med Univ, Dept Breast Surg, Affiliated Hosp 1, Kunming 650032, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Liang, Huichun,Ge, Fei,Xu, Yuhui,et al. miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells[J]. ANGIOGENESIS,2018,21(4):849-860.
APA Liang, Huichun.,Ge, Fei.,Xu, Yuhui.,Xiao, Ji.,Zhou, Zhongmei.,...&Chen, Ceshi.(2018).miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells.ANGIOGENESIS,21(4),849-860.
MLA Liang, Huichun,et al."miR-153 inhibits the migration and the tube formation of endothelial cells by blocking the paracrine of angiopoietin 1 in breast cancer cells".ANGIOGENESIS 21.4(2018):849-860.
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