Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora
Ding, Lin-Fen1,2,3; Su, Jia1; Pan, Zheng-Hong4; Zhang, Zhi-Jun1; Li, Xiao-Nian1; Song, Liu-Dong2,3; Wu, Xing-De1; Zhao, Qin-Shi1
2018-11-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume155Pages:182-190
Abstract

Nine previously undescribed sesquiterpenoids, named magnograndins A-I, as well as fourteen known ones, were obtained from the 70% acetone extract of the leaves of Magnolia grandiflora. Their structures were ascertained based on the spectroscopic evidences. The assignment of the relative configuration of magnograndin A was further confirmed by single-crystal X-ray diffraction analysis. 113,10a-Epoxyparthenolide, parthenolide, and micheliolide exhibited potent cytotoxic activity against MDA-MB-468, AGS, HCT116, Hela, and MDA-MB-231 human cancer cell lines with IC50 values ranging from 1.76 to 16.11 mu M. 1 beta,10 alpha-Epoxyparthenolide and micheliolide potently inhibited NF-kappa B transcriptional activity with IC50 of 13.92 and 8.95 mu M, respectively. The expression levels of NF-kappa B downstream protein p65 and XIAP were clearly down-regulated in 1 beta,10 alpha-epoxyparthenolide and micheliolide treated cells, which demonstrated the inhibition of NF-kappa B signaling pathway.

KeywordMagnolia Grandiflora (Magnoliaceae) Sesquiterpenoids Cytotoxic Activity Nf-kappa b Transcriptional Activity
DOI10.1016/j.phytochem.2018.08.006
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000447483900021
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/62788
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorWu, Xing-De; Zhao, Qin-Shi
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
4.Guangxi Inst Bot, Guangxi Key Lab Funct Phytochem Res & Utilizat, Guilin 541006, Peoples R China
Recommended Citation
GB/T 7714
Ding, Lin-Fen,Su, Jia,Pan, Zheng-Hong,et al. Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora[J]. PHYTOCHEMISTRY,2018,155:182-190.
APA Ding, Lin-Fen.,Su, Jia.,Pan, Zheng-Hong.,Zhang, Zhi-Jun.,Li, Xiao-Nian.,...&Zhao, Qin-Shi.(2018).Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora.PHYTOCHEMISTRY,155,182-190.
MLA Ding, Lin-Fen,et al."Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora".PHYTOCHEMISTRY 155(2018):182-190.
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