Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora
Ding, Lin-Fen1,2,3; Su, Jia1; Pan, Zheng-Hong4; Zhang, Zhi-Jun1; Li, Xiao-Nian1; Song, Liu-Dong2,3; Wu, Xing-De1; Zhao, Qin-Shi1
2018-11-01
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号155页码:182-190
摘要Nine previously undescribed sesquiterpenoids, named magnograndins A-I, as well as fourteen known ones, were obtained from the 70% acetone extract of the leaves of Magnolia grandiflora. Their structures were ascertained based on the spectroscopic evidences. The assignment of the relative configuration of magnograndin A was further confirmed by single-crystal X-ray diffraction analysis. 113,10a-Epoxyparthenolide, parthenolide, and micheliolide exhibited potent cytotoxic activity against MDA-MB-468, AGS, HCT116, Hela, and MDA-MB-231 human cancer cell lines with IC50 values ranging from 1.76 to 16.11 mu M. 1 beta,10 alpha-Epoxyparthenolide and micheliolide potently inhibited NF-kappa B transcriptional activity with IC50 of 13.92 and 8.95 mu M, respectively. The expression levels of NF-kappa B downstream protein p65 and XIAP were clearly down-regulated in 1 beta,10 alpha-epoxyparthenolide and micheliolide treated cells, which demonstrated the inhibition of NF-kappa B signaling pathway.
关键词Magnolia grandiflora (Magnoliaceae) Sesquiterpenoids Cytotoxic activity NF-kappa B transcriptional activity
资助信息Natural Science Foundation of China; Yunnan Applied Basic Research-Joint Special Project of Kunming Medical University; Science Research Foundation of Yunnan Provincial Education Department; Guangxi Key Laboraratory of Functional Phytochemical Research and Utilization; NSFC-Joint Foundation of Yunnan Province; Science and Technology Program of Yunnan province; CAS "Light of West China" Program; Youth Innovation Promotion Association CAS
语种英语
资助项目Natural Science Foundation of China[21662023] ; Natural Science Foundation of China[81773611] ; Natural Science Foundation of China[21602227] ; Yunnan Applied Basic Research-Joint Special Project of Kunming Medical University[2017FE467-016] ; Science Research Foundation of Yunnan Provincial Education Department[2017zDX156] ; Guangxi Key Laboraratory of Functional Phytochemical Research and Utilization[FPRU2016-3] ; NSFC-Joint Foundation of Yunnan Province[U1502223] ; Science and Technology Program of Yunnan province[2015FB173] ; Science and Technology Program of Yunnan province[2016FB140] ; CAS "Light of West China" Program ; Youth Innovation Promotion Association CAS
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62788
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Wu, Xing-De; Zhao, Qin-Shi
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
4.Guangxi Inst Bot, Guangxi Key Lab Funct Phytochem Res & Utilizat, Guilin 541006, Peoples R China
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GB/T 7714
Ding, Lin-Fen,Su, Jia,Pan, Zheng-Hong,et al. Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora[J]. PHYTOCHEMISTRY,2018,155:182-190.
APA Ding, Lin-Fen.,Su, Jia.,Pan, Zheng-Hong.,Zhang, Zhi-Jun.,Li, Xiao-Nian.,...&Zhao, Qin-Shi.(2018).Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora.PHYTOCHEMISTRY,155,182-190.
MLA Ding, Lin-Fen,et al."Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora".PHYTOCHEMISTRY 155(2018):182-190.
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