Poly p-hydroxybenzyl substituted bibenzyls and phenanthrenes from Bletilla ochracea Schltr with anti-inflammatory and cytotoxic activity
Li, Jin-Yu1,2; Yang, Liu1; Hou, Bo1,2; Ren, Fu-Cai1,2; Yang, Xiao-Bei1,2; Lv, Yong-Feng1,2; Kuang, Meng-Ting1,2; Hu, Jiang-Miao1; Zhou, Jun1
2018-09-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号129页码:241-248
摘要Ten previously undescribed stilbenoids, including six bibenzyls (bleochrins A-F, 1-6), three phenanthrenes derivatives (bleochrins G-J, 7-10) along with eleven known compounds were isolated from the rhizomes of Bletilla ochracea Schltr. The structural characterizations of 1-21 were accomplished by spectroscopic data, while the absolute stereostructure of 6 was confirmed by electronic circular dichroism (ECD) data analyses. All isolated metabolites except 7 were evaluated for cytotoxic activity against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480). Four isolates exhibited significant inhibitory ability against HL-60, SMMC-7721, and MCF-7 cell lines, with IC50 values ranging from 0.79 to 6.57 mu M. The isolates were tested further for inhibitory effects on the NO production of the liposaccharide (LPS)-induced RAW264.7 macrophages and showed activity with IC50 values at 15.29-24.02 mu M.
关键词Bletilla ochracea Stilbenoids Bibenzyls Phenaothrenes Cytotoxicity
资助信息Yunnan provincial science and technology department
DOI10.1016/j.fitote.2018.07.007
语种英语
资助项目Yunnan provincial science and technology department[2017ZF003] ; Yunnan provincial science and technology department[2015HB093] ; Yunnan provincial science and technology department[2018HA001]
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000443663800036
出版者ELSEVIER SCIENCE BV
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/62297
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者Hu, Jiang-Miao
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Li, Jin-Yu,Yang, Liu,Hou, Bo,et al. Poly p-hydroxybenzyl substituted bibenzyls and phenanthrenes from Bletilla ochracea Schltr with anti-inflammatory and cytotoxic activity[J]. FITOTERAPIA,2018,129:241-248.
APA Li, Jin-Yu.,Yang, Liu.,Hou, Bo.,Ren, Fu-Cai.,Yang, Xiao-Bei.,...&Zhou, Jun.(2018).Poly p-hydroxybenzyl substituted bibenzyls and phenanthrenes from Bletilla ochracea Schltr with anti-inflammatory and cytotoxic activity.FITOTERAPIA,129,241-248.
MLA Li, Jin-Yu,et al."Poly p-hydroxybenzyl substituted bibenzyls and phenanthrenes from Bletilla ochracea Schltr with anti-inflammatory and cytotoxic activity".FITOTERAPIA 129(2018):241-248.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Jin-Yu]的文章
[Yang, Liu]的文章
[Hou, Bo]的文章
百度学术
百度学术中相似的文章
[Li, Jin-Yu]的文章
[Yang, Liu]的文章
[Hou, Bo]的文章
必应学术
必应学术中相似的文章
[Li, Jin-Yu]的文章
[Yang, Liu]的文章
[Hou, Bo]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。