Formyl phloroglucinol meroterpenoids from Eucalyptus tereticornis and their bioactivities
Liu, Hui1,3; Feng, Mi-Yan1,2,3,6; Yu, Qian4; Yan, Huan1,3; Zeng, Yuan1,2,3; Qin, Xu-Jie1,3; He, Li5; Liu, Hai-Yang1,3
2018-03-29
发表期刊TETRAHEDRON
ISSN0040-4020
卷号74期号:13页码:1540-1545
摘要Five new formyl phloroglucinol meroterpenoids (FPMs), eucalteretials A-E (1-5), along with eight known analogues (6-13), were isolated from the twigs and leaves of Eucalyptus tereticornis. Their structures were established mainly by analysis of comprehensive spectroscopic data, and their absolute configurations were determined by electron circular dichroism (ECD) calculation. Within FPMs, both 1 and 2 are rare adducts of formyl phloroglucinol moiety and germacrene unit with different coupling patterns, respectively. Compound 3 exhibited significant cytotoxicity against HCT116 cell line with an IC50 value of 4.76 M. In addition, 5 and 9 were proved to be rare topoisomerase I (Top1) inhibitors. (C) 2018 Elsevier Ltd. All rights reserved.
关键词Eucalyptus Tereticornis Formyl Phloroglucinol Meroterpenoids Cytotoxicity Topoisomerase i Inhibitor
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60518
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
4.Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Med Chem & Chem Biol, Guangzhou 510006, Guangdong, Peoples R China
5.Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Yunnan, Peoples R China
6.Yunnan Univ, Sch Chem Sci & Technol, Kunming 650224, Yunnan, Peoples R China
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Liu, Hui,Feng, Mi-Yan,Yu, Qian,et al. Formyl phloroglucinol meroterpenoids from Eucalyptus tereticornis and their bioactivities[J]. TETRAHEDRON,2018,74(13):1540-1545.
APA Liu, Hui.,Feng, Mi-Yan.,Yu, Qian.,Yan, Huan.,Zeng, Yuan.,...&Liu, Hai-Yang.(2018).Formyl phloroglucinol meroterpenoids from Eucalyptus tereticornis and their bioactivities.TETRAHEDRON,74(13),1540-1545.
MLA Liu, Hui,et al."Formyl phloroglucinol meroterpenoids from Eucalyptus tereticornis and their bioactivities".TETRAHEDRON 74.13(2018):1540-1545.
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