Inhibition of 3,5,2 ',4 '-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice
Niu, Yanfen1,2,3,4; Zhou, Yuanfang2,5; Lin, Hua2; Gao, Li-Hui2; Xiong, Wenyong3; Zhu, Huajie6; Zou, Cheng-Gang1; Li, Ling2
2018
发表期刊BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN0918-6158
卷号41期号:1页码:99-105
摘要The mechanism of 3,5,2',4'-tetrahydroxychalcone on lowing urate level is still unknown. Here we investigated the effects of 3,5,2',4'-tetrahydroxychalcone on urate levels, xanthine oxidase/xanthine dehydrogenase (XOD/XDH) activities in hypoxanthine-induced hyperuricemic mice, as well as the effects of 3,5,2',4'-tetrahydroxychalcone on the mRNA expression levels and content of phosphoribosyl pyrophosphate synthetase (PRPS), phosphoribosyl pyrophosphate amidotransferase (PRPPAT) and hypoxanthine-guanine phosphoribosyl transferase (HGPRT). Our results demonstrated that 3,5,2',4'-tetrahydroxychalcone (1.0, 2.0, and 4.0 mg/kg) reduced the uric acid levels in serum of the hyperuricemic mice in dose-and time-dependent manners. The activities of XOD/XDH in serum and liver were also significantly inhibited by 3,5,2',4'-tetrahydroxychalcone; In addition, 3,5,2',4'-tetrahydroxychalcone decreased the mRNA expression of HGPRT in brain and content of PRPS and PRPPAT in liver. These findings demonstrated that 3,5,2',4'-tetrahydroxychalcone suppresses uric acid production by affecting the critical enzymes, XOD/XDH, PRPS, PRPPAT and HGPRT in purine nucleotide metabolism.
关键词Purine Metabolism Enzyme 3 Hyperuricemia 5 2 ' 4 '-tetrahydroxychalcone
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60471
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Yunnan Univ, State Lab Conservat & Utilizat Bioresources Yunnan, Kunming 650091, Yunnan, Peoples R China
2.Kunming Med Univ, Biomed Engn Res Ctr, Kunming 650500, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Chi, Kunming 650201, Yunnan, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Kunming Med Univ, Affiliated Hosp 2, Kunming 650101, Yunnan, Peoples R China
6.HeiBei Univ, Coll Pharm, Baoding 071002, Peoples R China
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Niu, Yanfen,Zhou, Yuanfang,Lin, Hua,et al. Inhibition of 3,5,2 ',4 '-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2018,41(1):99-105.
APA Niu, Yanfen.,Zhou, Yuanfang.,Lin, Hua.,Gao, Li-Hui.,Xiong, Wenyong.,...&Li, Ling.(2018).Inhibition of 3,5,2 ',4 '-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice.BIOLOGICAL & PHARMACEUTICAL BULLETIN,41(1),99-105.
MLA Niu, Yanfen,et al."Inhibition of 3,5,2 ',4 '-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice".BIOLOGICAL & PHARMACEUTICAL BULLETIN 41.1(2018):99-105.
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