Sesquiterpene amino ether and cytotoxic phenols from Dendrobium wardianum Warner
Zhang, Cong1,2; Liu, Shou-Jin2; Yang, Liu1,4; Yuan, Ming-Yan1,2; Li, Jin-Yu1,4; Hou, Bo1,4; Li, Hong-Mei1,4; Yang, Xing-Zhi1,4; Ding, Chang-Chun3; Hu, Jiang-Miao1,4
2017-10-01
发表期刊FITOTERAPIA
ISSN0367-326X
卷号122页码:76-79
摘要A new bibenzyl derivative, dendrocandin V (1) and a new sesquiterpene amino ether, wardianumine A (2), together with eleven known compounds, including phenanthrenes (denbinobin (3), 9,10-dihydro-denbinobin (4), mostatin (5), loddigesiinols A (6)), bibenzyls (moscatilin (7), 5-hydroxy-3,4'-dimethoxybibenzyl (8), 3,4dihydroxy-5,4'-dimethoxy bibenzyl (9), dendrocandin A (10), gigantol (11), dendrocandin U (12)) and an alkaloids (dihydroshihunine, 13) were isolated from the EtOH extraction of stems of Dendrobium wardianurn Warner. Isolation. of the new compound 2 indicated that N,N-dimethylethanolamine as the key adduction in the synthesis of dendroxine and its analogs in Dendrobium species. The hypothetical biosynthetic pathway of 2 was then postulated. Inspired by literature and traditional usage of the herbal medicine, some compounds were sent for cytotoxic activity and the results indicated that compounds 1, 3, 4, 5 showed cytotoxic activities against five human cancer cell lines (HL-60, A-549, SIVIMC-7721, MCF-7, and SW-480) with IC50 from 2.33-38.48 mu M. Among those compounds, 3 and 4 showed cell line selectivity with strong activity comparable to DDP.
关键词Dendrobium Wardicuzum Warner Dendrocandin v Wardianumine a Cytotoxic Activity
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/60356
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Anhui Univ Chinese Med, Sch Pharm, Hefei 230012, Anhui, Peoples R China
3.Wenshan Univ, Coll Environm & Resource, Wenshan 663099, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
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Zhang, Cong,Liu, Shou-Jin,Yang, Liu,et al. Sesquiterpene amino ether and cytotoxic phenols from Dendrobium wardianum Warner[J]. FITOTERAPIA,2017,122:76-79.
APA Zhang, Cong.,Liu, Shou-Jin.,Yang, Liu.,Yuan, Ming-Yan.,Li, Jin-Yu.,...&Hu, Jiang-Miao.(2017).Sesquiterpene amino ether and cytotoxic phenols from Dendrobium wardianum Warner.FITOTERAPIA,122,76-79.
MLA Zhang, Cong,et al."Sesquiterpene amino ether and cytotoxic phenols from Dendrobium wardianum Warner".FITOTERAPIA 122(2017):76-79.
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